<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12305

Description mediator of RNA polymerase II transcription subunit 19a-like
SequenceMDPDSKSFGRGPRELTGAVDLISHFKLLPHHEFFCKRSLPLSISDAHYLHNVVGDTEIRKGEGMQLDQLIQDTSLSRETSSRIQPFDLDVLGEAFQLREAAPVVLPPSEKGIPTVAGKSKSESKDKDKKHKKHRDKDKEKDKEHKKHKHRHKDRSKDKDKEKNRDKSGHHDSGADHSKKHREKKRKHDGEDLNDVHKHKRSKHKSSKIDEIGAIKVAG
Length218
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-1.374
Instability index38.37
Isoelectric point9.56
Molecular weight24900.71
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IBA:GO_Central

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12305
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.03|      14|      15|     129|     143|       1
---------------------------------------------------------------------------
  129-  142 (27.26/10.39)	KHKKHRDKDKEKDK
  145-  158 (26.78/ 6.48)	KKHKHRHKDRSKDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.17|      17|      33|     159|     175|       2
---------------------------------------------------------------------------
  159-  175 (31.92/14.42)	DKEKNRDKSGHHDSGAD
  177-  191 (26.62/10.77)	SK.KHREKKRKHD.GED
  194-  209 (26.63/10.78)	DVHKHK.RSKHKSSKID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.72|      12|      14|      49|      60|       3
---------------------------------------------------------------------------
   49-   60 (19.79/14.36)	LHNVVGDTEIRK
   66-   77 (18.93/13.48)	LDQLIQDTSLSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12305 with Med19 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LREAAPVVLPPSEKGIPTVAGKSKSESKDKDKKHKKHRDKDKEKDKEHKKHKHRHKDRSKDKDKEKNRDKSGHHDSGADHSKKHREKKRKHDGEDLNDVHKHKRSKHKSSKIDEIGAIKVAG
97
218










Molecular Recognition Features






MoRF SequenceStartStop




1) HSKKHREKKRKHDGEDLNDVHKHKRSKHKSSKIDEIGAIKVA
2) KDKDKKHKKHRDKDKEKDKEHKKHKHRHKDRSKDKDKEK
176
124
217
162