<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12303

Description cyclin-dependent kinase E-1-like
SequenceMGDGNTSSRGGNSNSSNRPEWLQHYDLIGKIGEGTYGLVFLAKIKANRSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINQADMSLYLAFDYAEHDLYEIIRHHRDKVNQAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEHGVIKIADFGLARIYQAPLEPLAKNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTPEKWPTLVNLPHWQSDVQRIQGHKYDNPALYSVLHLPPKSPAYDLLSKMLEYDPRKRITATQALEHEYFRMEPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPSQPVSSGNAASGGMQGPHVMPNRTVPRPMPMVNMQRMQPQAMSAYNLASQAGMGAGMNPGNMPMQRGVAAQAHQQQMRRKDPGMGMPGYPPQQKSRRF
Length473
PositionKinase
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy-0.465
Instability index40.42
Isoelectric point9.35
Molecular weight53027.32
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12303
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.62|      27|      28|     409|     435|       1
---------------------------------------------------------------------------
  373-  397 (29.41/12.37)	....LQPsQPVSSGNAAS.GGMqGPHVMPN
  409-  435 (53.61/28.08)	MQR.MQP.QAMSAYNLASQAGM.GAGMNPG
  439-  463 (40.60/19.63)	MQRgVAA.QAHQQQMRRKDPGM...GM.PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.11|      16|      17|     184|     200|       2
---------------------------------------------------------------------------
  184-  200 (26.00/19.08)	QAPlEPL..AKNGV.VVTIW
  202-  220 (22.11/11.29)	RAP.ELLlgAKHYTsAVDMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.20|      18|      35|      77|      95|       3
---------------------------------------------------------------------------
   77-   95 (27.27/24.41)	LREITHENVVKlVNVHINQ
  111-  128 (32.92/24.16)	LYEIIRHHRDK.VNQAINQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.37|      19|      36|     249|     284|       4
---------------------------------------------------------------------------
  248-  268 (25.72/14.10)	FQLDQLDK..IFKVLgHpTPEKW
  284-  304 (28.65/34.22)	IQGHKYDNpaLYSVL.H.LPPKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.58|      18|      38|     312|     329|       5
---------------------------------------------------------------------------
  312-  329 (29.15/14.28)	KMLEYDPRKRITATQALE
  331-  344 (18.50/ 6.86)	EYFRMEP...LPGRNAL.
  352-  368 (27.94/13.43)	KIVNY.PTRPVDTTTDFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12303 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MEPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPSQPVSSGNAASGGMQGPHVMPNRTVPRPMPMVNMQRMQPQAMSAYNLASQAGMGAGMNPGNMPMQRGVAAQAHQQQMRRKDPGMGMPGYPPQQKSRRF
335
473










Molecular Recognition Features






MoRF SequenceStartStop




1) AQAHQQQMRRKDPGMGMPGYPPQQKSRRF
2) KSIAIKKFK
445
50
473
58