<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12299

Description mediator of RNA polymerase II transcription subunit 16-like
SequenceMNNLQPPPPPPVAVKDSEEESSSAITTTNSLEASNKVQDKPDTGEDDHPRAAIVATEKEVSSVDNDDPMEEDSVNPATVFCIRLKQPRSNLLHKMSVPELCRNFRYSACAHYYTLILVVIRMFFPFNAAMMECSTDSPRDSVQFIEWSPTSCPRALLIANFHGRITIWTQTSQGPANLVRDASCWQREYEWRQDIAVVTKWLSGVSPYRWLSTRTGGSAKSTFEEKFLSQQPQSPAGWPNFLCVCSVFSSGSVQLHWSQWPPNQNGTPSKWFCTSKGLLGAGPSGIMAADAIITDSGAMHVAGVPIVNPSTVVVWEVTPGPGNGFQATPKTSVSNGIPPSLNPPSWDGFAPLAAYLFSWQEYLLQEAKQGKKLTEQHYNDMVALHCSPVSNFSAYVSPEAAAQSTATTTWGSGVTAVAFDPTRGGSVVAVVIVEGQYMSPYDPDEGPSITGWRVQRWESSVEDVVLHQIFGNPTSSFGGQAPKQTVWVSKVIKCIPAGNDFNRPLAVGAGPVSDGRNMADSGMEMGKRVSFDPFDLPSDVRTLARIVYSAHGGEIAVAFLRGGVHVFSGPSFTPVDNYHIDVGSAISAPAFSSTSCCSASVWHDTSRDCTILKIIRVLPPAVPSNQVKANSANWERAIAERFWWSLLVEVDWWDAVGCTQSAAEDGIVALNSVIAVLDADFHSLPSTQHRQQYGPVCFFYLNLSSSLSFS
Length710
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.10
Grand average of hydropathy-0.168
Instability index49.37
Isoelectric point5.31
Molecular weight77219.89
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12299
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     472.77|     148|     232|     195|     355|       1
---------------------------------------------------------------------------
  195-  355 (239.15/141.99)	IAVVTKWLSGVSPYRWLSTRTGG.....SAKSTFEEKFLSQQPQSPAGW........pnfLCVCSVFssGSVQLHWSQWPPNQNGTPSKWF.CTSKG.......LLGAGP..SGIMAADAIItDSGAmHVAGVPIVNPSTV.VVWEVTPGPGNGFQATpkTSVSNGIpPSLNPPSwdgFAPLAAY
  404-  578 (233.63/108.52)	STATTTWGSGVTAVAFDPTRGGSvvavvIVEGQYMSPYDPDEGPSITGWrvqrwessvedVVLHQIF..GNPTSSFGGQAPKQTVWVSKVIkCIPAGndfnrplAVGAGPvsDGRNMADSGM.EMGK.RVSFDPFDLPSDVrTLARIVYSAHGGEIAV..AFLRGGV.HVFSGPS...FTPVDNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.83|      24|      25|      18|      41|       4
---------------------------------------------------------------------------
   18-   41 (37.36/22.44)	EEESSSAITTTNSLEASNKVQDKP
   45-   68 (39.47/24.07)	EDDHPRAAIVATEKEVSSVDNDDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12299 with Med16 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNNLQPPPPPPVAVKDSEEESSSAITTTNSLEASNKVQDKPDTGEDDHPRAAIVATEKEVSSVDNDDPM
1
69










Molecular Recognition Features






MoRF SequenceStartStop




NANANA