<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12289

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X1
SequenceMDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSHSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDKGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1356
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.753
Instability index70.85
Isoelectric point9.44
Molecular weight149068.31
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12289
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.94|      15|      15|     283|     297|       1
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  283-  297 (30.92/ 7.99)	QSMMQSHMQQQQQQQ
  301-  315 (28.02/ 6.30)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     256.19|      41|      42|     393|     433|       2
---------------------------------------------------------------------------
  360-  387 (38.40/ 6.21)	VLHQRSQSVMRQQQAPMLHQ.....QQSAM..L.Q......Q
  393-  433 (77.67/21.98)	QQHQQQQLIAQQANATNLQQNQLIGQQNTMPDV.QQRIVGQQ
  439-  477 (53.36/12.22)	L..QQQQLLNQQNNLQNMHQQQL.GSQSNIAGVqQQQLTGSQ
  487-  519 (43.24/ 8.15)	NQHPIHML..QQSK.VPLQQQMLQGGTTLLP...SQ...GQQ
  858-  885 (43.52/ 8.26)	QQYHQRQ..........MQQ.QLYNRQQFMQ...QQQAKQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     303.54|      39|      39|     921|     959|       3
---------------------------------------------------------------------------
  154-  197 (35.65/ 6.45)	QTQTRQPLLQQNiqnnmasTG.LQNS..AS..LTPAL.PPVS.NLTQATM....P
  526-  566 (42.86/ 9.61)	QQQMMSQS.QSQ.......PG.QLQPplGLqqQTNQLQREMQ.QRLQTSG....P
  609-  646 (34.78/ 6.07)	LQEEVYQKIKSM.......RE.MYLP..EL..N..DLYQKIAAKVQQHDS...lP
  722-  761 (40.10/ 8.40)	QPQSLD...GQG.......NP.PMQP..VQ..GSMAAMQQNNITNLQHNSlsgvP
  766-  805 (38.49/ 7.70)	SQQHMVNTVQSG.......STvDLGQ..GN..SLNSLQQVATGSLQQNPV....N
  921-  959 (67.50/20.38)	QQQSVGQRVGSH.......HP.QLKP..GI..SSPQIHQALSPQVTQHPS....P
  963-  997 (44.17/10.18)	QQNMLASLTKSG.......TP.LL.S..A...SSPFVVP..SPSTPLAPS....P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     173.32|      42|     110|     101|     145|       4
---------------------------------------------------------------------------
    1-   47 (55.65/16.06)	MDGNNWRAA......................................QAQAQAQGGGEGASAAGPPTGAMDSgdwrtQLLPDSRQ
  104-  145 (76.32/27.97)	METKSQNPI......................................NNSMQPNAASSGQNALGPGSHSMQS.....QVNSQAQQ
  272-  347 (41.35/12.77)	MKQKFQ...pgstqqsmmqshmqqqqqqqpqdqqqqqqqqqqqqqqqQNLLQPTQIQSSQQTMMQPS.SMQS.....TSLSNLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.02|      14|      26|    1063|    1076|       5
---------------------------------------------------------------------------
 1063- 1076 (23.40/14.86)	VSGKSSVEQPLERL
 1092- 1105 (19.17/10.66)	VSDISSVVSMIDRI
 1156- 1169 (21.45/12.92)	VSSSSSVNDSFWQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.84|      14|      38|     999|    1018|       6
---------------------------------------------------------------------------
 1010- 1042 (13.05/ 6.61)	ALHTTAGNImhqqatvasapaqslaigtPG....ISA
 1044- 1061 (17.80/11.29)	PLLAEFTSL...................DGthanVSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.57|      22|      47|    1245|    1266|       8
---------------------------------------------------------------------------
 1245- 1266 (38.69/21.91)	LSPNLKSQYASAQMSPIQPLRL
 1294- 1315 (36.87/20.49)	LSMKAKSRFSVSLRSLSQPMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.44|      15|     275|     568|     585|      10
---------------------------------------------------------------------------
  252-  266 (29.06/10.89)	QQQSQTSQQ.YLYQQQ
  569-  584 (25.38/15.16)	QQQNVMEQQkQLYQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      72.99|      25|      29|     652|     680|      11
---------------------------------------------------------------------------
  652-  675 (21.65/14.00)	........E...QIEKLKVFKMTLErvvvFLRLNK
  676-  701 (25.19/ 8.68)	HDIQPshkEkllQVEKHISF.........FLNSNR
  703-  721 (26.15/ 8.28)	RKPTP...P...LQGQLPQPSMQLQ..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      15|      19|     807|     825|      12
---------------------------------------------------------------------------
  811-  825 (26.91/16.07)	NISSLNSHSG....TNPVQ
  827-  845 (21.41/ 7.22)	NLGSLQPNSNvlqqSLPKQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12289 with Med15 domain of Kingdom Viridiplantae
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