<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12287

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X3
SequenceMDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVATGSLQQNPVNSPQQVNISSLNSHSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDKGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1333
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.758
Instability index71.47
Isoelectric point9.47
Molecular weight146739.86
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12287
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     349.35|      53|      55|     469|     521|       1
---------------------------------------------------------------------------
  281-  326 (59.53/11.55)	TQQSmmqSHMQQQQQQQPQ...DQ..QQQ........QQQQ...QQ............QQQQQQNLL.Q..P..TQIQS
  327-  371 (50.72/ 8.44)	SQQT.....MMQPSS..MQ...ST..SL...SNL..QQNQQ...ST...........vQQSTQSVLH.Q..RSQSVMRQ
  372-  424 (47.75/ 7.39)	QQAP..mLH.........Q...QQsaMLQ..QPILPAQQHQ...QQqliaqqanatnlQQNQLIG.Q.Q....NT.MPD
  425-  486 (68.44/14.69)	VQQR...IVGQQNNYSSLQ...QQ..QLLNQQNNLQNMHQQqlgSQ......sniagvQQQQLTGSQ.Q..PGNSGVPS
  487-  540 (70.34/15.37)	NQHP...IHMLQQSKVPLQ...QQ..MLQGGTTLLPSQGQQ...SQ........sqpaQQQMMSQSQsQ..PGQL....
  541-  594 (52.58/ 9.10)	.QPP...LG.LQQQTNQLQremQQ..RLQTSGPLLQQQNVM...EQ............Q.KQLYQPQ.RaaPEASS.TS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     276.56|      51|      55|     109|     159|       2
---------------------------------------------------------------------------
   14-   47 (38.21/ 7.84)	........QAQGGGEG.AS......AAGPPTGAMD..SG.DWRTQLLP.....DS....R....Q
  109-  159 (89.79/30.14)	QNPINNSMQPNAASSG.QN......ALGPGSHSMQ..SQVNSQAQQLPVPMVANQT.QTR....Q
  163-  210 (49.86/12.88)	QQNIQNNM....ASTGlQNsasltpALPPVSNLTQ..AT.......MPNVMGQNANlQTM....Q
  217-  259 (59.25/16.94)	QNSVGNAIGQGMPS....N......MVANSQRQMQgrQQVVSQQQQ.......QQS.QTS....Q
  711-  745 (39.44/ 8.37)	...............G.Q........LPQPSMQLQ..QPQSLDGQGNP.PM..QPV.QGSmaamQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     481.27|     106|     107|     880|     985|       3
---------------------------------------------------------------------------
  610-  759 (65.71/17.81)	...................QEEVYQKIKSMREMYLPELN...DL.........YQKIAA............KVQQHDSlpqrPQTEQ.........IEKLKvfkmtlervvvflR.......LNKHDiQPshkekLLQVEKhiSF.FLNS.NRPRKPTP.PLQgqlpqpsmqlqqpqsldgqgnppmqpvqgsmaamqqnnitnlQHNSLSG
  760-  874 (133.66/44.40)	VPTISNSQQHMVATGSL.QQNPVN....S..PQ.QVNIS.SLNS.........HSGTNPvqanlgslqpnsNVLQQSL....PKQHE.........QQMLQ.............NqqlrqqyHQRQM.QQ.....QLYNRQ..QF.MQQQQAKQQQTAQLP............................................AHQMSQL
  880-  985 (180.68/62.79)	ANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGIS.SPQI.........HQALSP............QVTQHPS....PQIDQ.........QNMLA.............S.......LTKSG.TP.....LLSASS..PF.VVPSPSTPLAPSPMPGD..........................................SEKVSAG
  992- 1096 (101.21/31.70)	AGNI.MHQQATVASAP.AQSLAIGT..........PGISaSPLLaeftsldgtHANVSA............AVSGKSS......VEQplerlmkvvKNM..........................SP.KA.....LNSSVS..DIsSVVSMIDRIAGS.APGN..........................................GSRAAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.57|      22|      47|    1222|    1243|       4
---------------------------------------------------------------------------
 1222- 1243 (38.69/19.81)	LSPNLKSQYASAQMSPIQPLRL
 1271- 1292 (36.87/18.52)	LSMKAKSRFSVSLRSLSQPMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.43|      13|      20|      72|      88|       6
---------------------------------------------------------------------------
   72-   88 (15.33/28.45)	LKKIAVrfeeKIYTAAT
   94-  106 (22.09/20.18)	LRKISL....KMLTMET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12287 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVATGSLQQNPVNSPQQVNISSLNSHSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
955
1
694
438
257
252
990
45
950
613
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA