<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12286

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X4
SequenceMDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDKGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1324
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.756
Instability index70.93
Isoelectric point9.44
Molecular weight145782.82
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12286
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.78|      15|      15|     283|     297|       1
---------------------------------------------------------------------------
  283-  297 (32.38/ 9.82)	QSMMQSHMQQQQQQQ
  301-  315 (28.40/ 7.30)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     344.58|      56|      56|     469|     524|       5
---------------------------------------------------------------------------
  148-  211 (50.14/ 9.55)	...VP..MV..ANQ...TQTrQP....llqqniQNNMASTGL.QNSASLTPA.LPPVSNLTQATMPnvmGQ...NANLQTMQN
  212-  245 (42.79/ 6.78)	...MQ..NV..GQN...SVG.NA..........IGQ............GMPSN.....MVANS.......Q...RQM.QGRQQ
  410-  452 (46.41/ 8.15)	L..QQ..NQliGQQ...NTM.PD..........VQQRIVG.Q.QNNYSS..........LQQQQLL...NQ...QNNLQ....
  453-  511 (78.05/20.09)	.......NM..HQQqlgSQS.NI.......agvQQQQLTGSQ.QPGNSGVPSNQHPIHMLQQSKVP...LQ...QQMLQGGTT
  512-  566 (70.65/17.30)	L..LP..SQ..GQQ...SQS.QP.........aQQQMMSQSQsQPGQL.....QPPLG.LQQQTNQ...LQremQQRLQTSGP
  757-  823 (56.55/11.97)	LsgVPtiSN..SQQ...HMV.NTvqsgstvdlgQGNSLNSLQ.QA.NLG..SLQPNSNVLQQS.LP...KQ.heQQMLQN.QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     425.06|     109|     109|     990|    1098|       6
---------------------------------------------------------------------------
  906-  989 (101.94/46.90)	................PG..I..........S.SP.QI..........HQ...ALSPQVTQHPSpqI.....DQQ..N...MLASLTKSGTP..LLSASSPFV.VPSPSTPLA.PSpMPGDSEKVSAGLALhtTAGNIMHQ
  990- 1098 (174.63/85.26)	QATVASAPAQSLAIGTPG..I..........SASP.LLAEF.TSLDGTHA...NVSAAVSGKSS..V.....EQP.LE...RLMKVVKNMSPKALNSSVSDISSVVSMIDRIA.GS.APGNGSRAAVGEDL..VAMTKCRL
 1099- 1208 (113.15/52.81)	QAR..NYFTQDGATGTKK..MkryttsnvvsSSSS.VNDSF.WQLHCSEAselESTAT....SS..V.....KRPrLEvnhALVEEIQNIN.RQLIDTVVEISD.........kGV.DPSAVASATEGGEG..ITV.KCSF
 1221- 1281 (35.34/11.75)	YASAQMSPIQPLRLLVPAnyP..........NCSPvLLDKFpVEVSKEYE...DLSMKAKSRFS..VslrslSQP.M................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.63|      23|      49|     579|     601|       7
---------------------------------------------------------------------------
  579-  601 (37.57/21.61)	QLYQPQRAAPEASSTSLDSTAQT
  612-  629 (27.99/13.86)	EVYQKIKSMREMYLPEL.....N
  630-  651 (37.08/21.22)	DLYQ.KIAAKVQQHDSLPQRPQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.44|      23|      95|     249|     274|       9
---------------------------------------------------------------------------
  249-  271 (44.07/13.87)	QQQQQQSQTSQQYLYQQQMHHQM
  348-  368 (32.44/12.86)	NQQSTVQQSTQSVLHQRSQ..SV
  846-  868 (41.92/12.53)	QQQAKQQQTAQLPAHQMSQLHQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.72|      20|      95|      24|      47|      10
---------------------------------------------------------------------------
   24-   43 (38.94/20.02)	AAGPPTGAMDSG.DWRTQLLP
  127-  147 (32.79/ 8.78)	ALGPGSHSMQSQvNSQAQQLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12286 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
946
1
694
438
257
252
981
45
941
613
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA