<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12284

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X2
SequenceMDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQANATNLQQNQLIGQQNTMPDVQQRIVGQQNNYSSLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADLQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVVFLRLNKHDIQPSHKEKLLQVEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSHSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKSGTPLLSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSSSVNDSFWQLHCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDKGVDPSAVASATEGGEGITVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1353
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.756
Instability index70.84
Isoelectric point9.47
Molecular weight148765.99
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12284
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     510.22|      55|      55|     469|     523|       1
---------------------------------------------------------------------------
  210-  256 (51.44/ 9.97)	QNMQNVGQN.SVGNAigqGMP....SN..................MVAN.S......Q...RQ..M.QGRQQVV.SQ...QQQQQS....Q
  291-  333 (57.89/12.43)	QQQQ...QQ.QPQDQ...QQQ....QQQ...................QQ.QQQQQ..Q...QN..LLQ......PTQiqsSQQTMM....Q
  338-  394 (45.38/ 7.66)	QSTSLSNLQ.QNQQS...TVQ...qSTQ.SVL.......HqrsqsVMRQ.QQAPMlhQ...QQsaMLQ..QPILPAQ.............Q
  396-  438 (51.32/ 9.93)	QQQQLI.AQ.QANAT...NLQ....QNQ...........L.....IGQQ.NTMPD..V...QQ..RIVG.......Q....QNNYS....S
  469-  523 (102.48/29.42)	QQQQLTGSQ.QPGNS...GVP....SNQ.HPI.......H.....MLQQ.SKVPL..Q...QQ..MLQGGTTLLPSQ...GQQSQS....Q
  526-  575 (61.06/13.64)	QQQMMSQSQsQPGQL............Q.PPL.......G......LQQ.QTNQL..QremQQ..RLQTSGPLL..Q....QQNVM....E
  742-  802 (45.33/ 7.64)	QQNNITNLQ.HNSLS...GVPtisnSQQ.HMV.......N.....TVQSgSTVDL.gQ...GN..SLNSLQQVATGS...LQQNPV....N
  803-  865 (49.24/ 9.13)	SPQQVNISS.LNSHS...GTN....PVQ.ANLgslqpnsN.....VLQQ.S.LPK..Q.heQQ..MLQNQQLRQQYH...QRQMQQ....Q
  874-  926 (46.06/ 7.92)	QQQQ.AKQQ.QTAQ.....LP....AHQmSQL.......H....qMNDA.NDLKM..R...QQ..M..G...LKPGV...LQQQQSvgqrV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.35|      49|      53|     109|     157|       2
---------------------------------------------------------------------------
   18-   61 (57.67/20.14)	GGEGASA...AGPPTGAMDSG.DWRT..QL.....LP.....DSRQR.ivNKI.METLKRHL
   62-  120 (53.36/18.00)	PVSGQEGvqeLKKIAVRFEEKIYTAAtsQQdylrkISLKMLTMETKSQ..NPI.NNSMQPNA
  121-  170 (80.32/31.35)	ASSGQNA...LGPGSHSMQSQVNSQA..QQ.....LPVPMVANQTQTR..QPLlQQNIQNNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.81|      32|      37|     938|     969|       3
---------------------------------------------------------------------------
  938-  969 (54.25/24.98)	SSPQIHQALSP.QVTQHPSPQIDQQNMLASLTK
  970- 1001 (50.42/22.63)	SGTPLLSASSP.FVVPSPSTPLAPSPMPGDSEK
 1016- 1048 (41.14/16.92)	MHQQATVASAPaQSLAIGTPGISASPLLAEFTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.35|      17|      22|     694|     715|       4
---------------------------------------------------------------------------
  694-  715 (25.94/21.81)	LnsNRPR....KPTPPLQgqlP.QPSM
  717-  738 (26.41/ 8.78)	L..QQPQsldgQGNPPMQ...PvQGSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.76|      21|     108|    1092|    1129|       5
---------------------------------------------------------------------------
 1055- 1084 (26.03/34.32)	NVSAAVSGKSSVEQPLERLmkvvknmspKA
 1109- 1129 (35.74/13.28)	NGSRAAVGEDLVAMTKCRL.........QA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.57|      22|      47|    1242|    1263|       6
---------------------------------------------------------------------------
 1242- 1263 (38.69/22.45)	LSPNLKSQYASAQMSPIQPLRL
 1291- 1312 (36.87/21.00)	LSMKAKSRFSVSLRSLSQPMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.67|      23|     180|     259|     284|       7
---------------------------------------------------------------------------
  259-  284 (37.98/25.54)	QQYLYQQQMHHQMMKQKfQPGStqQS
  441-  463 (43.69/19.41)	QQQLLNQQNNLQNMHQQ.QLGS..QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.37|      16|      38|     607|     622|       8
---------------------------------------------------------------------------
  607-  622 (27.68/17.03)	QE..EVYQKI..KSMREMYL
  623-  642 (17.12/ 7.07)	PElnDLYQKIaaKVQQHDSL
  647-  661 (21.57/11.26)	QT..EQIEKL..KVFK.MTL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12284 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHSMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQ
2) LSASSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
3) MDGNNWRAAQAQAQAQGGGEGASAAGPPTGAMDSGDWRTQLLPDS
4) SFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVPTISNSQQHMVNTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSHSGTNPVQANLGSLQPNSNVLQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYNRQQFMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGLKPGVLQQQQSVGQRVGSHHPQLKPGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKS
5) SLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADLQEEV
6) TSQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQQPQDQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSAMLQQPILPAQQHQQQQLIAQQ
97
975
1
691
438
257
252
1010
45
970
610
404










Molecular Recognition Features






MoRF SequenceStartStop




NANANA