<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12283

Description pre-mRNA-processing protein 40A-like isoform X1
SequenceMPDEVKLARQSMKVDLVKGLGKERDSISHASDFGSISGVKTSPLSANGSPVSAQGAMSSPIAVAPVSNLPTIVASESSSLSGNISSLTIGAVEMQNSLEPASPAVATSEKNGTAVTLENSVATPVTSSEFPSAQDSVVYEDGVSLENTEEVKKDATVSETGSATPSEEKTVEPGPLVYESKAEAKSAFKILLESANIGSDWTWDQAMRAIINDRRYGALKSLGERKQAFNEYLSHKKKLEAEERRIKQKKAREDFRIMLEECKELAPSTRWSKAISIFEHDERFKAVERAKDREDLFEDYMEELEKKERARALEEQKRNRVEYLEFLKSCDFIKASSQWRKVQDRLEDDERCSCLEKIDRLEIFQEYIRDLEREEEEHRKLRMDEMRKAERKNRDEFRKLMEEHVAAGILNAKTNWRDYCIKVKDLPAYLAVSSNTSGPKAKDLFQDVFDELEKQYLDDKSRIRDAIRMAEIGLTSTWTLEDFKVAISKDISSPPISDTNLKFVFEELLERAREREEKEAKRRKRLADEFYELLHTSKEITASSKWEDCKSIFGDRIMGEESFLLEIFDKFISELKEKAKEKERKRQEDKARKEKERKDREKKKEKHRRDKDRGDKSRKERERTKKDGTDSEKADTYSFEEIKRLGSDRDKKHRKRHMSSFDDNENEKDHSRNSYRHDNDHKKSKQVDQHVWSSEVNSEGQHKKQKRDHRSGSLRDGDNEDHKDGEFGEDGEVR
Length734
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-1.106
Instability index45.83
Isoelectric point6.00
Molecular weight84802.55
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
U1 snRNP	GO:0005685	IBA:GO_Central
U2-type prespliceosome	GO:0071004	IBA:GO_Central

GO - Biological Function
RNA binding	GO:0003723	IBA:GO_Central

GO - Biological Process
mRNA cis splicing, via spliceosome	GO:0045292	IEA:InterPro
mRNA splicing, via spliceosome	GO:0000398	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12283
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     453.53|      65|      65|     242|     306|       1
---------------------------------------------------------------------------
  167-  233 (61.56/29.06)	.........EEK.TV..EpgplvyesKAEAK..................SAFKIL.L.E...SANIG.SDWTWDQAMRAIIN.D.RRYGAL...K..SL.GERKQAFNEYL
  237-  301 (104.40/54.49)	KKL.EA...EER.RI..K........QKKAR..................EDFRIM.LEE...CKELA.PSTRWSKAISIFEH.D.ERFKAV...E..RA.KDREDLFEDYM
  302-  368 (83.74/42.23)	EEL.EK...KERaRAleE........QKRNR..................VEYLEF.LKS...CDFIK.ASSQWRKVQDRLED.D.ERCSCL...E..KI..DRLEIFQEYI
  369-  449 (60.57/28.47)	RDL.EReeeEHR.KL..R.mdemrkaERKNR..................DEFRKL.MEEhvaAGILN.AKTNW.RDYCIKVK.DlPAYLAVssnT..SG.PKAKDLFQDVF
  450-  531 (44.62/19.00)	DEL.EK.................qylDDKSRirdairmaeigltstwtlEDFKVA.I.....SKDISsPPISDTNLKFVFEElL.ERARER...EekEA.KRRKRLADEFY
  532-  572 (51.70/23.21)	E......................................................lLHT...SKEIT.ASSKWEDCKSIF...G.DRIMGE...E..SF...LLEIFDKFI
  573-  630 (46.93/20.38)	SELkEKakeKER.KR..Q........EDKAR.................kEKERKD.REK...KKE.K.H..RRDKD....RG.D.KSRKER...E..RTkKDGTD......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.56|      19|      19|     668|     686|       2
---------------------------------------------------------------------------
  649-  666 (23.95/10.48)	RD.KKHR.KRHMSSFDDNEN
  668-  686 (33.91/17.85)	KDHSRNS.YRHDNDHKKSKQ
  688-  705 (21.69/ 8.81)	DQHVWSSeVNSEGQHKK..Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.34|      37|      40|      48|      86|       3
---------------------------------------------------------------------------
   48-   86 (53.76/42.46)	GSpVSAQGAM..SSPiAVAPVSNLPTIVASESSSLSGNISS
   90-  128 (54.58/33.54)	GA.VEMQNSLepASP.AVATSEKNGTAVTLENSVATPVTSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12283 with Med35 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKEKERKRQEDKARKEKERKDREKKKEKHRRDKDRGDKSRKERERTKKDGTDSEKADTYSFEEIKRLGSDRDKKHRKRHMSSFDDNENEKDHSRNSYRHDNDHKKSKQVDQHVWSSEVNSEGQHKKQKRDHRSGSLRDGDNEDHKDGEFGEDGEVR
2) QNSLEPASPAVATSEKNGTAVTLENSVATPVTSSEFPSA
3) TEEVKKDATVSETGSATPSEEKTVEPGPLV
579
95
148
734
133
177










Molecular Recognition Features






MoRF SequenceStartStop




1) DREKKKEKHRRDKDR
2) EFGEDGEV
3) KADTYSFEEIKRL
4) QHKKQKR
5) QHVWSSEVN
599
726
633
701
689
613
733
645
707
697