<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12274

Description mediator of RNA polymerase II transcription subunit 33A-like isoform X2
SequenceMLWFLLLLQAEMEKIFEMAVKGADDEKIAAATILCGASLIHGWNIQEHTVNFITRLLSPPVPTDYSGKDSHLIGYAPTLNVLLVGIAPVDCVQIFSLHGMVPQLAASLMTICEVFGSCAPNISWTLTTGEDISVHAVFSNAFALLLKLWRFNHPPIEYRVGDVPPVGCQLTPEYLLLMRNSHLVSSGDMLKDPNRRRLAAVASSSSPNPIFVDSFPKLRVWYRQHLACIASTLSGLVNGTLVCQTVDLLLNMMFKKINGGSQSLISITSGSSSSSGTGSEDTSPRPKLPAWDILEAVPFVVDAALTACAHGRLSPRELCTGLKDLADFLPASLATIVSYFSAEVTRGVWKPVFMNGTDWPSPAANLSNVEEQIKKILAATGVDVPSLAAGGSSPAILPLPLAAFVSLTITYKLDKASQRFLNLAGPALESLAAGCPWPCMPIVASLWTQKAKRWSDFLVFSASRTVFLNNNHAVIQLLKSCFMTTLGLNSSSISSNGGIGALLGHGFGSHFYGGISPVAPGILYLRVYRSIRDIMFLREEIVSLLIQSISDIAHSELPRQRLGKLKKSKNGKKFGNVSLAKTMTRVKLAALLGASLLWLSGGSGLVQSLIKETLPSWFLSVHSSNQGGEGGLVPMLKGYALAYFAVLCGAFASGVDSLSMASKRRPKIIGRHVEFIASVLDGKISLGCDPATWHAYVSGFVSLMVGCTPTWVFEVDAELLKRLSKGLRQWHEEDLALALLSIGGVGTMGSAAELIMEVSS
Length760
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy0.314
Instability index39.75
Isoelectric point8.60
Molecular weight81585.06
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12274
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.91|      20|      67|     315|     338|       1
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  315-  334 (35.93/17.99)	PRELCTGLKDLAD...FLPASLA
  558-  580 (26.98/10.52)	PRQRLGKLKKSKNgkkFGNVSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.92|      51|     236|     359|     432|       2
---------------------------------------------------------------------------
  359-  411 (80.32/34.51)	WPSPAANLsnVEEQIKKILAATGVDVPSLAAG....GSS...PAILPLPLAAFVSLTITY
  598-  651 (84.02/32.02)	WLSGGSGL..VQSLIKETLPSWFLSVHSSNQG....GEGglvPMLKGYALAYFAVLCGAF
  676-  705 (21.58/26.39)	.........................IASVLDGkislGCD...PATWHAYVSGFVSLMV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     325.19|      80|     243|     190|     276|       3
---------------------------------------------------------------------------
   60-  135 (109.16/61.51)	PVPTDYSG.K.....DSHLIGYAPTLNVLLVGIAPVD.CVQIFsLHGMVPQL...AASLMTICEvfGSC...aPNISWTL....TTGEDISVH
  136-  208 (95.21/56.71)	AVFSNAFAlLLKLWRFNH.PPIEYRV.GDV.PPVGCQlTPEYL.LLMRNSHLVSSGD............mlkdPNRRRLA....AVASSSSPN
  209-  285 (120.81/76.85)	PIFVDSFP.KLRVWYRQHLACIASTLSGLVNGTLVCQ.TVDLL.LNMMFKKINGGSQSLISITS..GSS...........sssgTGSEDTSPR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12274 with Med33 domain of Kingdom Viridiplantae
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