<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12273

Description mediator of RNA polymerase II transcription subunit 33A-like isoform X4
SequenceMEKIFEMAVKGADDEKIAAATILCGASLIHGWNIQEHTVNFITRLLSPPVPTDYSGKDSHLIGYAPTLNVLLVGIAPVDCVQIFSLHGMVPQLAASLMTICEVFGSCAPNISWTLTTGEDISVHAVFSNAFALLLKLWRFNHPPIEYRVGDVPPVGCQLTPEYLLLMRNSHLVSSGDMLKDPNRRRLAAVASSSSPNPIFVDSFPKLRVWYRQHLACIASTLSGLVNGTLVCQTVDLLLNMMFKKINGGSQSLISITSGSSSSSGTGSEDTSPRPKLPAWDILEAVPFVVDAALTACAHGRLSPRELCTGLKDLADFLPASLATIVSYFSAEVTRGVWKPVFMNGTDWPSPAANLSNVEEQIKKILAATGVDVPSLAAGGSSPAILPLPLAAFVSLTITYKLDKASQRFLNLAGPALESLAAGCPWPCMPIVASLWTQKAKRWSDFLVFSASRTVFLNNNHAVIQLLKSCFMTTLGLNSSSISSNGGIGALLGHGFGSHFYGGISPVAPGILYLRVYRSIRDIMFLREEIVSLLIQSISDIAHSELPRQRLGKLKKSKNGKKFGNVSLAKTMTRVKLAALLGASLLWLSGGSGLVQSLIKETLPSWFLSVHSSNQGGEGGLVPMLKGYALAYFAVLCGAFASGVDSLSMASKRRPKIIGRHVEFIASVLDGKISLGCDPATWHAYVSGFVSLMVGCTPTWVFEVDAELLKRLSKGLRQWHEEDLALALLSIGGVGTMGSAAELIMEVSS
Length749
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy0.295
Instability index39.43
Isoelectric point8.68
Molecular weight80226.37
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12273
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.30|      33|      67|     178|     210|       1
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  178-  210 (60.42/41.03)	MLKDPN..RRRLAAV..ASSSSPNPIFVDS..FPKLRVW
  242-  280 (44.89/28.42)	MFKKINggSQSLISItsGSSSSSGTGSEDTspRPKLPAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     379.08|      77|     127|     312|     388|       2
---------------------------------------------------------------------------
  312-  384 (112.94/70.56)	............................................KDLAD...FLPASLATIVSYFSAEVTRGVWKPVFMNGTDWPSP..AANLS.....NVEEQIKKILAATGVDVPSLAAG....GSS...PA
  385-  428 (45.42/23.21)	ILPL...................................................................................plAAFVSltityKLDKASQRFLNLAGPALESLAAG....CPW...PC
  441-  510 (91.48/55.51)	............................................KRWSD...FLVFSASRTVFLNNNHAVIQLLKSCFMTTLGLNSS..SIS.S.....N..GGIGALL...GHGFGSHFYG....GISpvaPG
  511-  619 (62.97/35.52)	ILYLrvyrsirdimflreeivslliqsisdiahselprqrlgklKKSKNgkkFGNVSLAK.......TMTRVKLAALLGASLLWLSG..GSGL.......VQSLIKETLPSWFLSVHSSNQG....GEG.....
  621-  680 (66.26/37.83)	....................................................LVPMLKGYALAYFA..VLCG....AFASGVD........SLS.....MASKRRPKIIGRHVEFIASVLDGkislGCD...PA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12273 with Med33 domain of Kingdom Viridiplantae
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