<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12270

Description pre-mRNA-processing protein 40A-like isoform X1
SequenceMASNPPPSGPQPLWPPSVGSTPPQGFGSSFPMQFRPAVSTQQGQPFASSISASPQYRPVGQTSNAGMPPGHHSQIPQFSQPMQQFPPRPNQPGHGILLSQAIQMPFIQSSMPQPQQVIPPLNSHMPGVSGAGNPFSSSYTVQSSSQMHVPSFPSGGQPWLSSGSQNTPVTAPTLLTNQQLSAIAPSVPAGTASPQNASDWQEYEAADGRRYYYNKITKQSSWEKPLELMTPLERADASTVWKEFTTADGRKYYYNKETKQSKWTIPEELKLARELAEKSAGQVVQTGASTTSGVQVTAAVTSTEQPSAVTPVSFTPSSTVSGVASSPVPVTSAVSDHASPLVVSGSSAIPAVTPAMPSSSGVSSPAVSGSTGSAALANASQTQMSGFENLSPQVSSSLSGASIQDIEEAKKGMAVAGKVNVVPAEEKTTEEEPFLYATKQEAKNAFKALLEFANVESDWTWEQTMRVIINDKRYGALKTLGERKQAFNEYLMQRKKQEAEERRHRQRKAKEEFTKMLEESKELISSTRWSKAVTMFEDDERFKAVEREADREDLFRNYLVDLQKKERAKAQEEYRQNRLEYRHFLETCGFIKVDTQWRKVQDLLEDDERCLRLEKIDRLDIFQEYIRDLEKEDEEQRKLQKEQLRRTERKNRDAFRKMMEEQITAGTLTAKTSWRDYCQMVKESVAYQAVASNTSGSTPKDLFEDVVEELEKQYHEDKIRVKDVVKSEKITISSTWTFEDFKATILEGIGSPSIHDVNLQLIFEDLIERAKEKEEKETKKRQRLAKDFTDKLSTIKEITASSSWEECKELVEDTSEFRAIGEETISRAVFEEYVAWLQEKAKEKERRREEEKAKKEKEKEEKEKRKDKERREKEREKEKERDKEKERGNERATKDEADSESMDVTDNYEPKEERKREKDRERKHRKRHHISNDEVTSDKDEKEEPERDKERKHRKRHHSSNDELASDKDEKEESKRSRRHSSDRKKSKKLAHSPESDGESRHKRHRRDHRDGSRRNGGGYEELEDGELGEDGES
Length1034
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-1.095
Instability index60.05
Isoelectric point6.11
Molecular weight117595.08
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
U1 snRNP	GO:0005685	IBA:GO_Central
U2-type prespliceosome	GO:0071004	IBA:GO_Central

GO - Biological Function
RNA binding	GO:0003723	IBA:GO_Central

GO - Biological Process
mRNA cis splicing, via spliceosome	GO:0045292	IEA:InterPro
mRNA splicing, via spliceosome	GO:0000398	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12270
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.69|      23|      23|     842|     864|       1
---------------------------------------------------------------------------
  842-  862 (30.45/11.70)	...KEKERRREEEKAKKEK.........EKEEK
  863-  879 (21.30/ 6.03)	EKrKDKERR......EKER.........EKE.K
  940-  971 (24.95/ 8.29)	DE.KEEPERDKERKHRKRHhssndelasDKDEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     134.49|      22|      23|      24|      45|       2
---------------------------------------------------------------------------
   11-   43 (36.48/18.78)	QPlwppsvgstppQGF.GSSF...PMQFRPAVSTQQ.G
   44-   66 (19.28/ 6.61)	QP..............fASSIsasP.QYRPVGQTSNaG
   67-   93 (30.48/14.54)	MP...pghhsqipQ.F...SQ...PMQQFPPRPNQP.G
   95-  112 (20.22/ 7.27)	..............GI.LLSQ...AIQM.PFIQSSM.P
  356-  372 (28.02/12.80)	MP...........SSS.GVS........SPAVSGST.G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.44|      29|      40|     199|     238|       3
---------------------------------------------------------------------------
  199-  227 (61.07/28.79)	DWQEYEAADGRRYYYNKITKQSSWEKPLE
  240-  268 (58.37/42.34)	VWKEFTTADGRKYYYNKETKQSKWTIPEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     480.37|      66|      66|     507|     572|       4
---------------------------------------------------------------------------
  440-  504 (86.91/55.27)	QEAKNAFKALLEF...A.NVESDWTWEQTMRVIINDKRYGALKTL...GERKQAFNEYLMQRK.....K.........QEAEERRH
  507-  572 (106.49/69.52)	RKAKEEFTKMLEE...SKELISSTRWSKAVTMFEDDERFKAVERE...ADREDLFRNYLVDLQ.....K.........KERAKAQE
  575-  648 (86.97/55.31)	RQNRLEYRHFLET...CGFIKVDTQWRKVQDLLEDDERCLRLEK....IDRLDIFQEYIRDLE.....KedeeqrklqKEQLRRTE
  649-  713 (66.47/40.38)	RKNRDAFRKMMEEqitAGTLTAKTSWRDYCQMVKESVAYQAVASNtsgSTPKDLFEDVVEELE.....K.........Q.......
  720-  774 (55.48/32.38)	.RVKD....VVKS...EKITISST.WT.....FED...FKATILE...GIGSPSIHD..VNLQlifedL.........IERAKEKE
  783-  841 (78.04/48.80)	RLAK.DFTDKLST...IKEITASSSWEECKELVEDTSEFRAIGEE...TISRAVFEEYVAWLQ................EKA....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.53|      24|      28|     279|     302|       5
---------------------------------------------------------------------------
  279-  298 (27.63/14.80)	.........SA.GQVVQTGASTTSGVQVTA
  299-  327 (31.10/17.58)	AVTS.teqpSAvTPVSFTPSSTVSGVASSP
  329-  354 (28.79/15.73)	PVTSavsdhAS.PLVV.SGSSAIPA..VTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.98|      30|      32|     126|     155|       6
---------------------------------------------------------------------------
  126-  155 (56.19/37.72)	PGV.SGAGNPFSSSYTVQSSSQMH..VPSFPSG
  158-  190 (45.79/29.27)	PWLsSGSQNTPVTAPTLLTNQQLSaiAPSVPAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.34|      19|      32|     880|     907|       7
---------------------------------------------------------------------------
  880-  900 (27.96/33.22)	ERDKEKERgnERATK.......DEADSE
  913-  938 (27.38/ 8.55)	ERKREKDR..ERKHRkrhhisnDEVTSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.70|      17|      25|     974|     998|       8
---------------------------------------------------------------------------
  958-  979 (21.06/ 7.13)	HSSN....DELASdkdekEESKRSRR
  980- 1004 (19.64/23.57)	HSSDrkksKKLAH.spesDGESRHKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12270 with Med35 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KERRREEEKAKKEKEKEEKEKRKDKERREKEREKEKERDKEKERGNERATKDEADSESMDVTDNYEPKEERKREKDRERKHRKRHHISNDEVTSDKDEKEEPERDKERKHRKRHHSSNDELASDKDEKEESKRSRRHSSDRKKSKKLAHSPESDGESRHKRHRRDHRDGSRRNGGGYEELEDGELGEDGES
2) MASNPPPSGPQPLWPPSVGSTPPQGFGSSFPMQFRPAVSTQQGQPFASSISASPQYRPVGQTSNAGMPPGHHSQIPQFSQPMQQFPPRPNQPGHGILLSQAIQMPFIQSSMPQPQQVIPPLNSHMPGVSGAGNPFSSSYTVQSSSQMHVPSFPSGGQPWLSSGSQNTPVTAPTLLTNQQLSAIAPSVPAGTASPQNASDWQ
844
1
1034
201










Molecular Recognition Features






MoRF SequenceStartStop




1) GYEELEDGEL
2) ILLSQAIQ
3) KKSKKLAHS
4) SRHKRHRRDHRD
1019
96
985
1000
1028
103
993
1011