<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12259

Description mediator of RNA polymerase II transcription subunit 25-like isoform X5
SequenceMVVFAVHGSHGACLVRRSGWTRDIDMFFQWLSAIPFSGGGFNDAAVAESLAEALTMFSSLNGSQTQQNVDWQRHCILIAASNPYPLPTPVYHPHMQNVEQSGNIEAHTANRLSDAETVAKEFPQCSVSLSVICPKQLPKLRAIYNAGKRDPQAADPPIDTSKNPNFLVLISENFIEACAAFNRTGMESSALNQSLVEMDMSSVAPVSAPAATFNPAGSVMSQQPISAGNIPAATINMEPTTVTSVTGPALPHIPTARPTSQLVASLQSASPISVSEEVVPNNEIVNETKPILSGMTQPLHSFSGAAANARILNDVAQAQALVGGTSIGLQSMGETPILSNMMSGGISSSIPAAPTVLSSGQLAVTSMSGLVPLAGTGQIAQNSVSASSVSIAPSMSGNSNLCVSQLLSNIQGGVSAGMHQNVLSGTGAGMPFGQGTLMSTPRMTQQGHPGMQPLSRNNSTEANMPLSQQQTSATLSSAQSNYVKVWEGDLSGQRQGEPVLITRLQGFRIASASKLLAANWPQTMQIDRLITQEHLNNDVRRLIGKAEIVVFWAMDQHVFLGQLQEKKFCAVIQLSSQTMILSVSDKTCRLIGMLFPENMVVFKPQIPSQQLEAQHPRLEQLLLQQSLPLLQQQQPLQQLQQQQRLMPLKRKPNIPLQQQPKIPKLHRQQTPQIQQQQQIPQMQQTEQQQPIIGTCLNQASTGGTRRAQLMSQGQASSRGLPNMP
Length724
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.178
Instability index58.00
Isoelectric point8.07
Molecular weight77668.74
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12259
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.13|      16|      16|     648|     663|       2
---------------------------------------------------------------------------
  648-  663 (30.15/12.00)	LKRKPNIPLQQQPKIP
  665-  680 (28.60/11.01)	LHRQQTPQIQQQQQIP
  681-  693 (21.38/ 6.43)	QMQQTE...QQQPIIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.45|      18|      18|     336|     353|       3
---------------------------------------------------------------------------
  215-  233 (22.19/ 8.17)	PAGSVMSQQPISAgNIPAA
  336-  353 (35.26/17.45)	PILSNMMSGGISS.SIPAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.07|      11|      15|     407|     417|       4
---------------------------------------------------------------------------
  407-  417 (18.97/ 9.63)	LSNIQGGVSAG
  423-  433 (21.10/11.58)	LSGTGAGMPFG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.40|      22|     142|      36|      59|       5
---------------------------------------------------------------------------
   36-   59 (29.15/25.95)	FSGGGFNDAAVAESLAEaLTMfSS
  181-  202 (39.25/23.94)	FNRTGMESSALNQSLVE.MDM.SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.08|      28|      73|     292|     323|       6
---------------------------------------------------------------------------
  265-  297 (38.65/23.41)	SLQS....ASPISVSEEVVPNNEIVNetkpiLSGMTQ
  298-  334 (32.43/29.16)	PLHSfsgaAANARILNDVAQAQALVGgtsigLQSMGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.88|      11|      26|     358|     369|       7
---------------------------------------------------------------------------
  358-  369 (16.58/10.74)	SSGQLAvTSMSG
  387-  397 (20.30/ 9.29)	SSVSIA.PSMSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      11|      31|     602|     612|       9
---------------------------------------------------------------------------
  602-  612 (20.56/ 8.79)	FKPQIPSQQLE
  630-  640 (19.95/ 8.31)	LQQQQPLQQLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.62|      20|      54|     450|     469|      10
---------------------------------------------------------------------------
  450-  469 (35.84/19.54)	GMQPL...........SRNNSTEANMPLSQQ
  495-  525 (23.78/10.47)	QGEPVlitrlqgfriaSASKLLAANWPQTMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12259 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GMPFGQGTLMSTPRMTQQGHPGMQPLSRNNSTEANMPLSQQQT
2) PLKRKPNIPLQQQPKIPKLHRQQTPQIQQQQQIPQMQQTEQQQPIIGTCLNQASTGGTRRAQLMSQGQASSRGLPNMP
429
647
471
724










Molecular Recognition Features






MoRF SequenceStartStop




1) QPKIPKLH
2) RKPNIPLQ
3) RRAQLM
659
650
705
666
657
710