<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12258

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMCKNALGAEKRLLIKQRKASQLEPRLEIRQKRKRGIKESEELKAEVRARTTRGEQQSICRIFGKAHMMEKQLIVAVEGTAAVGPFWQTIISDYLDKMIRSFTKLEPIEKKPSAGNWQLAMVVFAVHGSHGACLVRRSGWTRDIDMFFQWLSAIPFSGGGFNDAAVAESLAEALTMFSSLNGSQTQQNVDWQRHCILIAASNPYPLPTPVYHPHMQNVEQSGNIEAHTANRLSDAETVAKEFPQCSVSLSVICPKQLPKLRAIYNAGKRDPQAADPPIDTSKNPNFLVLISENFIEACAAFNRTGMESSALNQSLVEMDMSSVAPVSAPAATFNPAGSVMSQQPISAGNIPAATINMEPTTVTSVTGPALPHIPTARPTSQLVASLQSASPISVSEEVVPNNEIVNETKPILSGMTQPLHSFSGAAANARILNDVAQAQALVGGTSIGLQSMGETPILSNMMSGGISSSIPAAPTVLSSGQLAVTSMSGLVPLAGTGQIAQNSVSASSVSIAPSMSGNSNLCVSQLLSNIQGGVSAGMHQNVLSGTGAGMPFGQGTLMSTPRMTQQGHPGMQPLSRNNSTEANMPLSQQQTSATLSSAQSNYVKVWEGDLSGQRQGEPVLITRLQGFRIASASKLLAANWPQTMQIDRLITQEHLNNDVRRLIGKAEIVVFWAMDQHVFLGQLQEKKFCAVIQLSSQTMILSVSDKTCRLIGMLFPENMVVFKPQIPSQQLEAQHPRLEQLLLQQSLPLLQQQQPLQQLQQQQRLMPLKRKPNIPLQQQPKIPKLHRQQTPQIQQQQQIPQMQQTEQQQPIIGTCLNQASTGGTRRAQLMSQGQASSRGLPNMP
Length843
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.237
Instability index55.86
Isoelectric point9.22
Molecular weight91316.64
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12258
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      98.99|      16|      16|     767|     782|       2
---------------------------------------------------------------------------
  767-  782 (30.15/15.86)	LKRKPNIPLQQQ......PKIP
  784-  799 (28.60/14.58)	LHRQQTPQIQQQ......QQIP
  800-  812 (21.38/ 8.67)	QMQQTE...QQQ......PIIG
  822-  843 (18.87/ 6.61)	GTRRAQLMSQGQassrglPNMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     266.57|      46|      48|     324|     369|       3
---------------------------------------------------------------------------
  153-  215 (37.94/14.21)	IPFSGGG..FND.............A..AVAeslAEALT......................MfSS.LNGsQ....TQ..............qnvdwqrhciliAASNPY..PLPTP....VYH.PHMQ
  216-  271 (33.65/11.83)	NVEQSGN..IEA.............H..TAN..rLSDAE......................T.VA.KEF.PqcsvSL......................svicPKQLPKlrAIYN.....AGK.RDPQ
  275-  341 (43.00/17.03)	PPIDTSK..NPNflvlisenfieacA..AFN..............................R.TG.MES.S....AL.............nqslvemdmssvaPVSAPA..ATFNP....AGS.VMSQ
  342-  388 (61.44/27.29)	QPISAGN..IPA.............A..TIN...MEPTT......................V.TS.VTG.P....AL.......................phiPTARPT..SQL......VAS.LQSA
  389-  462 (33.47/11.73)	SPISVSEevVPN.............N..EIV...NETKP......................I.LSgMTQ.P.....LhsfsgaaanarilndvaqaqalvggtSIGLQS..MGETP....ILS.NMMS
  463-  500 (25.60/ 7.35)	GGISS.S..IPA.............AptVLS...SGQLA......................V.TS.MSG...............................................lvplAGTgQIAQ
  501-  587 (31.47/10.61)	NSVSASS..VSI.............A..P.S...MSGNSnlcvsqllsniqggvsagmhqnV.LS.GTG.A....GM....pfgqgtlmstprmtqqghpgmqPLSRNN..ST..E....ANM.PLSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.72|      11|      50|     660|     670|       4
---------------------------------------------------------------------------
  660-  670 (17.55/ 9.72)	RLIGKAEIVVF
  681-  691 (16.17/ 8.38)	QLQEKKFCAVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.51|      11|      31|     721|     731|       6
---------------------------------------------------------------------------
  721-  731 (20.56/ 9.99)	FKPQIPSQQLE
  749-  759 (19.95/ 9.46)	LQQQQPLQQLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12258 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GMPFGQGTLMSTPRMTQQGHPGMQPLSRNNSTEANMPLSQQQT
2) PLKRKPNIPLQQQPKIPKLHRQQTPQIQQQQQIPQMQQTEQQQPIIGTCLNQASTGGTRRAQLMSQGQASSRGLPNMP
548
766
590
843










Molecular Recognition Features






MoRF SequenceStartStop




1) KPNIPL
2) KRLLIKQR
770
10
775
17