<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12251

Description mediator of RNA polymerase II transcription subunit 33A-like
SequenceMKTETVHSIFDRVTELTKIAQEKNTDPLIWAMQLSSSLNAAGVSMPSVAVGEILVNHICWSNNVPIAWKFLEKALTVRIVPPLFVLALLSTRVIPTRRSCPMAYRLYMELLKRYAFSLPSLINGPNYRKIMESINDTLHLSQIFELQGSESGKHVVGYVFMVVWQLLDASLDDEGLLELTAEKKSRWPVATQEMEVSNRDGFAGKRVEHREGLCRMNTVLAIEIIGELFGDKLTSMILYLARKNMPTHWDSFMQHLQLLVSNSAALRNSKNISPEALVLLISKNLGVLSRECKTSSRQFFHAVMASGSLAFSASRRDAASTSVLWLPIDLFLEDTMDGFQVAATSSADTLTGLVKALQATNCITWQDTFFGLWVSALRLVNRERDSSEGPVPRLDTCLCLLLSITPLAITNIIEEEENDSTSSDQRKESTEKRCQALVSSLQQLHDYEGLLTPPLPAIPLANQAAVKAMMFLSGLSMGSEYFDGMKLSDMPVNCAGNLWHLIVEACIARNILDTSAYLWPGYVKGQCNQVPRSISGPLLGWSSLMKGSLLSPPMVSALVSTPASSLAEIEKIYEIAVDGSDEEKISAATILCGASLARGWNIQEHTVLFITRLLSPCIPSDYCGNESHLISYAPVLNVLLIGISSIDCIQIFSLHGLVPQLAGALMPICEVFGSCAPNVSWTLMSEKINSHAVFSNAFTLLLKLWRFDQPPLEHVTRDVPVGSHLTPEYLLLVRNSQLACSEDLLKGQSKSKQLSRTPRRLPEEPIFMDSFPKLKCWYRQNQACIASPLSGLVPGTPVHQIVEALLNFMFRKINSAGQSLTPTTSGGSNSSGSGNEDISPHLKLPAWDILEAVPFVLDAALTAGAHGQLSPRELATGLKDLADFLPASLATIASYFSAEVTRGLWKPAFMNGTDWPSPAANLATVEQQIKKILAATGVDVPSLSVGGNSPAILPLPLAVLASLTITYKLDRGTDRFLNLVGTALSNLATSCPWPCMPVIAALWAQKVRRWSDFLVFSASRTVFHHSSDAVVQLLRVCFTATLGLGTSSIESNGGVGSLLGHGFGSHFSGGISPVAPGILYLRVHRAVRNVMFMAEEVVTLLMHFVRIIADGGFPAEELEKLKKTRNPMSSLSCNNMESGFPAFCQVSLAAAMTRVKLAASLGASLVWITGGLSLVQSLLKETLPSWFISAHRSEPNGGVSEGMVARLRGYALAYFALLSGTFAWGVDSLSPASKWRPSILGAHLEFLASALDGKISLGCNKATWRAYVSGFIGLMVGCTPSWLLEVDVEVLKRLSKGLKRLNEEVLALALLEASGVGAMGTAAEMIIEGGLNFC
Length1334
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy0.201
Instability index44.75
Isoelectric point6.48
Molecular weight144900.26
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12251
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     257.70|      60|      70|     273|     332|       1
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  273-  332 (97.49/59.02)	SPEALVLLISKNLGVLSRECKTSSRQFFHAVMA......SGSLAFSASR...RDAASTSVLWLPIDLFL
  346-  400 (95.93/57.95)	SADTLTGLV.KAL..QATNCITWQDTFF.GLWV......S.ALRLVNRE...RDSSEGPVPRLDTCLCL
  979- 1037 (64.28/36.25)	.......LVGTALSNLATSCPWPCMPVIAALWAqkvrrwSDFLVFSASRtvfHHSSDAVVQLLRVC...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     527.89|     210|     516|      27|     252|       2
---------------------------------------------------------------------------
   27-  160 (159.06/128.73)	.............................................................................................................................................................................................................................................................................................................................................................................................PLI.WA..MQ...LSSS.........................................LNAAGVSM.PSVAVG........EI.LVNHIC..WSNNVPI.AWKFLEKALTVRIVP.....PLFVL.........ALLSTRVIPTrrsC.PMAYRLYMELLKRYAFSLPSLINGpnyrkiMESInDTLhlsQIFELQG...SESGKHV.VGYVF
  161-  252 (91.27/58.71)	MVVWQLLDASLDDEGLLE..LTAEKKsRWPVATQEMEVSNRDGFAGKRVEHREGLCRMNTVLAIEiiGELFGDKLTSMILYLARKNMPTH...WDSF.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  537-  672 (118.02/69.90)	.................................................................................................mqhlqllvsnsaalrnsknispealvllisknlgvlsrecktssrqffhavmasgslafsasrrdaastsvlwlpidlfledtmdgfqvaatssadtltglvkalqatncitwqdtffglwvsalrlvnrerdssegpvprldtclclllsitplaitniieeeendstssdqrkestekrcqalvsslqqlhdyeglltpplpaiplanqaavkammflsglsmgseyfdgmklsdmpvncagnlwhliveaciarnildtsaylwpgyvkgqcnqvprsisgPLLgWSslMKgslLSPP.........................................MVSALVST.PASSLA........EIeKIYEIAvdGSDEEKIsAATILCGASLARGWNiqehtVLFIT.........RLLSP........CiPSDYCGNESHLISYAPVLNVLLIG......ISSI.DCI...QIFSLHGlvpQLAGALMpICEVF
  678-  876 (159.54/95.15)	NVSWTLMSEKINSHAVFSnaFTLLLK.LWRFDQPPLEHVTRDVPVGSHLTPEYLLLVRNSQLACS..EDLLKGQSKSKQLSRTPRRLPEEpifMDSF.............................................................................................................................................................................................................................................................................................................pklkcwyrqnqaciasplsglvpgtpvhqiveallnfmfrkINSAGQSLtPTTSGGsnssgsgnED.ISPHL......KLP..AWDILEA......VP.......FVLdaaltagahGQLSPRELAT.....................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     272.07|      90|     285|     881|     975|       4
---------------------------------------------------------------------------
  881-  975 (142.97/92.62)	LADFLPASLATIASYFSaeVTRGLWK...PA.FMNG.TDWPSPAANLATVEQQIKKILA.........ATGVDvpSLSVGGN.SPAILPLPLAVLASlTITYKLDRGTDR
 1157- 1261 (129.10/70.47)	LAASLGASLVWITGGLS..LVQSLLKetlPSwFISAhRSEPNGGVSEGMVARLRGYALAyfallsgtfAWGVD..SLSPASKwRPSILGAHLEFLAS.ALDGKISLGCNK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12251 with Med33 domain of Kingdom Viridiplantae
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