<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12247
Description |
Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MWTNVFKIGGLHQISWFQFLPHESDVSSLVDKSVKLDKKDAATWLVLSSHLQLQKEGFLSTWTNSFVGPWDPSQGLHNPDEKIKLWLFSPGQHSSVVEKAQSAVSKLRVLASGLWVAPGDSEEVAAALSQALRNCMERKLRGLSYVRYGDVFTKHHPFSQNEELFRKGQPVVEFIFSATEEAIFVHVIISAKLIRALSSGDIDKISEDTSNVSGERLPVIVSPHGMRGRLTGCCPADLVKQVYLSSCKFSASNGIVGLPCNVSRSGYQLKGQNCYVEVSLGCTTPGNNNIKESSRMLIYPPEAILVPVVQTACARSSLKRFWLQNWIGPSLSFTSSFMHCFDFSSDAKVNSTDGSWLDANIMRSNRQYNSSSNSNSSSVSSVSTSSSDSDYKTSGAGDLEADADSLMCRPSGLSSVDQSRNDNLKTGFKRSRTGISESFSQAGAVINPSTSDYASMEVNNSAITGGNDQIGLQWGWDDDDRGVGMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMYPAADSADVGSSPCPSMMDVKDQMLLPVGFPSFDSFNQPPPPASLDDSLSKHQEVIKSTAVAYQVNNSSAAIAGEFDHLIKAEALMTFAPEYGAVETPTGEKSHLIFRNPYLPKSREVDTSNSSSDSYVYSATPPLSPYFDACEEKSGVTVNLKTGSGRRDTSSIIQSKRYYTHIESGKEKNDGKLSGSDHSCATREAQVEQSPFYGFNSTNSVKSIHNKTEKANEALLKADSFGQSMKTVLATEVECLMCQAFMCKIRHTLLSSSSYLPVGASRMSGSTIINQPQGEAVVTVDNMSSKSEMKKKEIIPVRIAGDIDGGLLDGTLNAQVGVWRSVGVSKGMKQPSSALEACHSVQHNSFIEESMLAYGLRQPLQELLDGVALLVQQATSLVDVALDADNNDGPYGWLTLQEQWRRGFSCGPSMVHAGCGGVLASCHSLDIAGVELIDPLSADVQASFALTLLQNDIKTAMKSAFGTMEGPLSVVDWCKGRSQSNDGGISGDGFSAESTASASECRDSSSTISFSVGEPISPSQSSAGGSSLKDGIRVDEASERRLSQDTCLSESEQLPGSRLRPTLSAVPYPAILVGYQDDWLKTSPSSLQLWEKAPFEPYAMPKHMSYYVVCPDINALTTAATDFFQQLGTVYETCKLGTHSPQCMGNEMEIDSGKNVSSGFVLIDCPQSMKIDSSSTSMLGSISDYFLSLSNGWDLESYLKSLSKVLRNLKLSSCMTMNPKEGSTGPCTVIYVVCPFPEPLAVLQTVVESSIAVGSVVLSSDKERRSTLQNQVGKALSYSAAVDESLSNVLTLSGFCIPKLVLQIVTVDAIFRVTSPALSELLVLKEIAFTVYNKARRISRGSSSDMVQSSSMSGRSHPVLMQMTSPVPGMWKDCVGPRSIGTSLQREAELDASLRSGSWDNWQISRGGSLGCDPNRIGDFSFQDEVRYLFEPLYILAEPGSLDRGLSFPMSGNLMAESSKLLLDDGTSGNFMQSSASSGGGDTGPNTQSETSEPDGFGSAHQKSLPSLHCCYGWTEDWRWLVCIWTDSRGELLDNYIYPFGGISSRQDTKGLQSLFVQILQQGCQILQACPPEAANAKPRDFVIARIGSFFELECQEWQKALYAIGGSEVKKWSLQLRRSVPDGMSASSNGTSLQQQEIGGMGQPSTRKQLIGGQGMVDNSRGLLQWVQSISFVSVSIDHSLQLMFQADIVSHGTSQSSGVLSQPGYLEGYTPVKSLGSTSNSYILIPSPNMRFLPPVGLQLHTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPTMRRDARSISKEEWPSVLSVSLVDYYGGSNIIQEKFFKGVGKVGGRGTSSETRDVEIETHLILENIAAELHALSWMTVSPAYLERRSALPFHCDMVLRLRRLLHFADKEVSRQPEKTQV |
Length | 1930 |
Position | Kinase |
Organism | Nicotiana tabacum (Common tobacco) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae>
Nicotiana.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.226 |
Instability index | 53.61 |
Isoelectric point | 5.36 |
Molecular weight | 209155.18 |
Publications | PubMed=24807620
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364134
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12247
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 124.54| 35| 40| 492| 527| 1
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492- 527 (60.80/39.58) SEFGDFGDFFENDVLPFGEPPGTAESQAlMYPAA..DS
533- 569 (63.75/37.45) SPCPSMMDVKDQMLLPVGFPSFDSFNQP.PPPASldDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 124.94| 43| 78| 853| 927| 2
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856- 910 (57.01/81.67) VGvskGMKQPSS...............ALeaCHSVQHNSFIEESmlaygLRQPLQELLDgvALLVQQATS
1673- 1730 (67.92/28.18) IG...GMGQPSTrkqliggqgmvdnsrGL..LQWVQSISFVSVS.....IDHSLQLMFQ..ADIVSHGTS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 144.65| 44| 86| 69| 113| 3
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69- 113 (72.76/59.77) PWDPSQGLHNPDEKIKLWLFSPGQHSSVVEKAQSAvSKLRVLASG
157- 200 (71.89/53.83) PFSQNEELFRKGQPVVEFIFSATEEAIFVHVIISA.KLIRALSSG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 210.72| 65| 78| 922| 988| 4
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922- 988 (108.35/58.95) DGPYG...WLTLQEQWRRGFSCGPSMvHAGCGGVLASCH.SLDIAGVELIDPLSADvQASFALTLLQNDIK
999- 1067 (102.37/49.10) EGPLSvvdWCKGRSQSNDGGISGDGF.SAESTASASECRdSSSTISFSVGEPISPS.QSSAGGSSLKDGIR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 40.97| 12| 31| 377| 388| 5
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377- 388 (19.70/10.49) SSVSSVSTSSSD
411- 422 (21.26/12.06) SGLSSVDQSRND
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 151.91| 44| 827| 656| 714| 6
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668- 714 (70.40/65.60) SGVTVNLKTGSGRRDTSSIIQSKryyTHIESGKEKNDGKLSGSDHSC
1502- 1545 (81.51/41.64) SGNFMQSSASSGGGDTGPNTQSE...TSEPDGFGSAHQKSLPSLHCC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.12| 18| 827| 389| 406| 7
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389- 406 (31.93/17.94) SDY..KTSGAGDLEADADSL
1217- 1236 (29.19/15.72) SDYflSLSNGWDLESYLKSL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 145.21| 45| 1112| 278| 348| 8
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289- 333 (84.66/78.64) NIKESSRMLIYP...................PEAILVPVVQTACARSSL.......KRFWLQNWIGPSLSF
1242- 1312 (60.55/19.16) NLKLSSCMTMNPkegstgpctviyvvcpfpePLAVLQTVVESSIAVGSVvlssdkeRRSTLQNQVGKALSY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 119.89| 34| 1112| 624| 657| 9
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624- 657 (59.92/37.96) SHLIFRNPYLPKSREVDTSNSSSDSYVYSATPPL
1733- 1766 (59.97/38.00) SGVLSQPGYLEGYTPVKSLGSTSNSYILIPSPNM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 234.57| 75| 442| 1349| 1428| 12
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1349- 1428 (115.99/95.23) SPALSELLVLKEIAF.............TVYNKARRISRGSSSDMVQSSSMSGRSHPVLMQmTSPVPGMWKdcVGPRsiGTSLQ.REAELDASL
1784- 1872 (118.58/78.77) SPPLAHLLHSKGCAIplstgfvvskavpTMRRDARSISKEEWPSVLSVSLVDYYGGSNIIQ.EKFFKGVGK..VGGR..GTSSEtRDVEIETHL
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