<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12231

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMGADKQLIVAVEGTAALGPFWHTIVSDYLDKIIRCFFGAESTSQKPSAANVEVSLVMFNAHGSYSACLVQRSGWTRDMDIFFQWLSAIPFSGGGFSDAAVAEGLGEALMMFSSPNGNQSQQNMEGKKHCLLISASNPYPLPTPVYRPQMQKLEQNENTETQTDSRLSDAETVAKAFPQCSVSLSVICPKQLSKLRAVYNAGKRNPRAADPPIDTAKNPNFLVLISENFIEARAAFSRPGMTNLTSNQSPVKMDVSSIPPVSVPPSISNSAANGSVMSRQPISAGNIPPATVKIEPTTVTSMNGPAFSHIPSVRPALQPVPSLQTSSPLSVSQEMASHNENVQEMKPVVSGMTQSLRPVAAAAANVRILNDVAQARQAIAGATSIGLQSMGGTPMLSSMISSGMASSVPSAQTVFSSGQSGVTTVSGSVPLAGSGQNTQNSAPASFTSSAPSMSGNPNISISQTLSGVSMAGQTVPGMCQGNLPGTQMMPSGTGMNQNMLTGLGATGMPSGTGTMMPTPGISQQGQPGMQPVGNSTGANMPLSQQQTPAALPSAQSKYVKVWEGNLSGQRQGQPVFITRLEGYRSASASESLAANWPPTMQIVRLISQDHMNNKQYVGKADFLVFRAMNQHGFLSQLQEKKLCAVIQLPSQTLLLSVSDKACRLIGMLFPGDMVVFKPQIPSQQQQQQQLQAQHPQLQQQQLSQQQQHISQLQQQPLQQLQQQQPLMQQQQQMHQMQQQQLPQMQQQQQISQMQQQQQIPQMQQQQQIPQMQQPQQQQPMVGTGVNQSYMQGPARSQLMSQGQVSSQGLPTMPGGGFMN
Length818
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.05
Grand average of hydropathy-0.348
Instability index61.19
Isoelectric point9.02
Molecular weight87561.47
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12231
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.64|      15|      15|     734|     748|       1
---------------------------------------------------------------------------
  683-  696 (29.63/ 8.69)	QQQQQ..QL.QAQH.PQL
  727-  743 (30.93/ 9.41)	QQQQQmhQM.QQQQLPQM
  744-  761 (27.07/ 7.26)	QQQQQisQMqQQQQIPQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.79|      16|      16|     476|     491|       2
---------------------------------------------------------------------------
  476-  491 (34.77/17.05)	GMCQGNLP..GTQMMPSG
  493-  510 (21.62/ 7.13)	GMNQNMLTglGATGMPSG
  519-  534 (22.41/ 7.73)	GISQQGQP..GMQPVGNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.43|      16|      51|     710|     725|       3
---------------------------------------------------------------------------
  704-  719 (29.38/11.45)	QQQHIS........QLQQQPLQQL
  774-  797 (23.05/ 7.11)	QQQQPMvgtgvnqsYMQGPARSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.63|      20|      21|     245|     264|       4
---------------------------------------------------------------------------
  248-  268 (24.01/ 6.20)	SPVKMDVSSIPPV.SVP.PsiSN.
  303-  323 (25.96/ 7.24)	GPAFSHIPSVRPA.LQPvP..SLQ
  401-  421 (23.66/ 6.01)	SGMASSVPSAQTVfSSG.Q..SGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.84|      33|      63|     368|     400|       5
---------------------------------------------------------------------------
  342-  382 (29.79/10.92)	....QEM..KPVVSGMTQ...............slrpvaaaaanvriLNDVAQARQAIAGAT
  383-  444 (41.90/18.34)	SIGLQSMGGTPMLSSMISsgmassvpsaqtvfssgqsgvttvsgsvpLAGSGQNTQNSAPAS
  446-  474 (35.15/14.21)	TSSAPSMSGNPNIS..IS...........................qtLSGVSMAGQTV....
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12231 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPSVRPALQPVPSLQTSSPLSVSQEMASHNENVQEMKPVVSGMTQ
2) MAGQTVPGMCQGNLPGTQMMPSGTGMNQNMLTGLGATGMPSGTGTMMPTPGISQQGQPGMQPVGNSTGANMPLSQQQTPAA
3) QIPQMQQQQQIPQMQQPQQQQPMVGTGVNQSYMQGPARSQLMSQGQVSSQGLPTMPGGGFMN
4) SVPPSISNSAANGSVMSRQPISAGNIPPATVKIEPTTVTS
5) SVPSAQTVFSSGQSGVTTVSGSVPLAGSGQNTQNSAPASFTSSAPSMSGNPNISISQTLSG
309
469
757
261
406
353
549
818
300
466










Molecular Recognition Features






MoRF SequenceStartStop




NANANA