<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12226

Description mediator of RNA polymerase II transcription subunit 25-like isoform X2
SequenceMMEKQLIVAVEGTAAVGPFWQTIISDYLDKMIRSFTKLEPIEKKPSAGNWQLAMVVFTVHGSHGACLVRRSGWTTDIDMFFQWLSAIPFSGGGFNDAAVAESLAEALTMFSSLNGSQTQQNVDGQRHCILIAASNPYPLPTPVYHPHMQNVEQSGNIEAHTANRLSDAETVAKEFPQCSVSLSVICPKQLPKLRAIYNAGKRDPQAADPPIDTSKNPNFLVLISENFIEACAAFNRTGMEISALNQILVEMDMSSVAPVSAPAATFDPAVMSQQPISAGSIPSATVNMEPTTVTSVTGPALPHIPTARPTSQLVASLQSASPISVSEEVVPNNEIVNETKPILSGMTQPLRSFSGAAANARILNDVAQAQALVGGTSIGLQSMGGTPILSNMIPGGISSSIPAAPTVLSSGQLAVTSMSGLVPLAGTGQIAQNSVSASSVSIAPSMSGNSNLCVSQLLSNIQGGVSAVMHQNVLSGTGAGMPFGTGTLMSTPRMTQPGHPGMQPLGRNNSTEANIPLSQRQTSATLSSAQSNYVKVWEGDLSGQRQGEPVLITRLQGFRIASASKSLAADWPQTMQIVRLITQEHLNNDVRRLIGKSEIVVFWAMDQHVFLSQLQEKKFCAVIQLPSQAMILSVSDKTCRLIGMLFPENTVVFKPQKLNQQLEAQHPQLEQLLLQQSLPLLQQQRALSRLQQQQPLQQLQQQQHLMPLKRKRNIPLQQQPKIPKLHRQQSPQIQQQQQIPQMQQTEQQQPIIGTCVNQASTGGPRRAQLMSQGQASSRGLPNVP
Length784
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.152
Instability index57.54
Isoelectric point8.66
Molecular weight84307.52
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12226
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.13|      24|      27|     696|     722|       1
---------------------------------------------------------------------------
  670-  696 (23.51/ 6.26)	EQLLLQQSL.PL.......LQQQRAL.........srlqqqqpL
  697-  731 (34.41/18.60)	QQLQQQQHLMPLKRKRnipLQQQPKI.........pklhrqqsP
  732-  770 (27.21/ 8.22)	Q.IQQQQQIPQMQQTE....QQQPIIgtcvnqastggprraqlM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.39|      24|      27|     332|     355|       2
---------------------------------------------------------------------------
  332-  355 (43.05/24.75)	NNEIVN...ETKPILSGMTQPLRSFSG
  359-  385 (31.34/15.89)	NARILNdvaQAQALVGGTSIGLQSMGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.09|      12|      27|     394|     420|       3
---------------------------------------------------------------------------
  394-  405 (22.71/ 6.39)	P.........GGIS.SSIPAAP
  423-  444 ( 8.38/ 8.22)	PlagtgqiaqNSVSaSSVSIAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.88|      11|      49|     592|     602|       4
---------------------------------------------------------------------------
  592-  602 (17.72/ 9.72)	RLIGKSEIVVF
  613-  623 (16.16/ 8.24)	QLQEKKFCAVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.44|      35|      36|     249|     284|       5
---------------------------------------------------------------------------
  204-  261 (34.89/15.09)	PQAA.DPPIdTSKNPnflvlISE..NFIEAcAafnrtgmeisalnqilVEMDMS.SVAPVSA
  262-  298 (51.61/30.13)	PAATfDPAV.MSQQP.....ISA..GSIPS.A...............tVNMEPT.TVTSVTG
  299-  331 (34.94/15.12)	PAL...PHI.PTARP.....TSQlvASLQS.A................SPISVSeEVVP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.53|      35|      66|     447|     482|       6
---------------------------------------------------------------------------
  447-  482 (54.41/35.58)	SGNSNLCVSQLLSNIQGGVSAVMHQNvLSGTGAGMP
  485-  516 (52.96/30.26)	TG.TLMSTPRMTQPGHPGMQPLGRNN...STEANIP
  518-  549 (51.16/28.96)	SQRQ...TSATLSSAQSNYVKVWEGD.LSGQRQGEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12226 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQQQPIIGTCVNQASTGGPRRAQLMSQGQASSRGLPNVP
2) GMPFGTGTLMSTPRMTQPGHPGMQPLGRNNSTEANIPLSQRQ
3) PLKRKRNIPLQQQPKIPKLHRQQSPQIQQQQQIPQMQQ
746
480
707
784
521
744










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRKRNIPLQQQPKIPKLHR
2) PRRAQLMS
708
764
727
771