<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12225

Description mediator of RNA polymerase II transcription subunit 8-like
SequenceMKRFVAVATNDIIPTIASSFPVTWNRTRLHAGSVAVPEEEVFVDPANAARMLQEALTRTGIFGPASGANIYLQSPRPENKQPKRIRSSATGEKNKRAKTNAPEPSLVAMTTGPPSGPVIDTDARSVEIVTRTEDNVSTLWGEYDLVENVDSHFQAPIAVSSAAGLSTGSLPFLVGKHLTASTAFDAALLAERDQTILRLSELKTKATEAVVLEAHLQQSEQELFDAHGSSGSGSEFSKTEEGSEGDNAEDQTRENVEPLVDPPTSLGNADTSLPTGSGDAAIWLFFSFSHFELLPFWYVLGRCEGSVGCHEGAQDQQPQQPLRVAEGLNPAVQQQLNLESVKTRAISLFKDISRILEDFDAIARNNAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPRNVNAENAAILPVMLSSKLLPEMEVEDNSKREQLLHSMQNLSVAPQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQENLLRTAVNHGEGLRVPGDQTHITSALPGHLVDVLTVTDGPPSFADSSGTYLKNTPPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQHSLQQQQHQQQQQQQQLQQHQLQQRQKIMQLPQHQQLLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLPSGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMSSQTLLPRMQFGISGGTRNLAAANLSDQMFNMSGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQKPQGQQ
Length837
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.05
Grand average of hydropathy-0.485
Instability index55.45
Isoelectric point5.98
Molecular weight91097.07
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12225
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.71|      26|      39|     669|     707|       2
---------------------------------------------------------------------------
  678-  703 (51.12/28.16)	QM...........QFSQPLGAQQFQGRQ.LPSGAIHHG
  708-  745 (31.60/14.72)	QLnqgnqlnrhlnQFSSPMNTALFNSAQsTPNSQMISN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.02|      19|      24|     780|     803|       3
---------------------------------------------------------------------------
  780-  801 (34.80/25.40)	FNMsgnNPGMMPIQQ.QQQHGTF
  809-  828 (33.23/11.22)	QNL...QQGMMPLQNtPQTHPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.90|      38|      39|     330|     367|       4
---------------------------------------------------------------------------
  330-  367 (61.80/49.94)	PAVQQQLNLES.VKTRAISLFKDISRILEDFDAIARN.NA
  369-  408 (57.11/45.53)	PKWQDILGQFSmVNLELFNIVEDIKKVSKAFVVHPRNvNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     193.27|      53|      55|     505|     559|       5
---------------------------------------------------------------------------
   56-   91 (36.27/16.15)	................LTRTGifGP.....A..SGANIYLQS.P..RPENK.QPKRIRssATG
  489-  520 (35.58/15.68)	.........................PTIDKA..QAAKIQEQE.NLLRTAVN.HGEGLR..VPG
  521-  576 (80.41/51.72)	DQTHITSalPGHLVDVLTVTD..GPPSFADS..SGTYLKNTP.PFSSSNVNsQGALLQ..ASG
  577-  616 (41.01/19.88)	ALRAAAS..PSGTTSFDTTTA..SPLPHVNSprSSANMMNTPsP...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.37|      27|     330|     417|     445|       6
---------------------------------------------------------------------------
  417-  445 (41.82/29.93)	MLSSK.LLPEMEVEDNSKREQLlhSMQNLS
  749-  776 (43.54/24.77)	MMSSQtLLPRMQFGISGGTRNL..AAANLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.36|      17|      62|     241|     259|       7
---------------------------------------------------------------------------
  241-  259 (27.06/20.77)	EGSEG..DNAEDQTREnvEPL
  304-  322 (28.30/15.13)	EGSVGchEGAQDQQPQ..QPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.78|      14|      19|     637|     654|       9
---------------------------------------------------------------------------
  637-  654 (19.20/20.40)	QHQLqqRQKIMqlPQHQQ
  659-  672 (26.58/13.14)	QQQL..RQASM..PGLGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12225 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELFDAHGSSGSGSEFSKTEEGSEGDNAEDQTRENVEPLVDPPTSLGNADTS
2) GANIYLQSPRPENKQPKRIRSSATGEKNKRAKTNAPEPSLVAMTTGPPSGPVIDTDARSVE
3) PSFADSSGTYLKNTPPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQHSLQQQQHQQQQQQQQLQQHQLQQRQKIMQLPQHQQLLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLPSGAIHHGMGQSQLNQGNQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMS
4) TLLPRMQFGISGGTRNLAAANLSDQMFNMSGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQKPQGQQ
222
67
544
754
272
127
751
837










Molecular Recognition Features






MoRF SequenceStartStop




NANANA