<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12224

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMMEKQLIVAVEGTAAVGPFWQTIISDYLDKMIRSFTKLEPIEKKPSAGNWQLAMVVFTVHGSHGACLVRRSGWTTDIDMFFQWLSAIPFSGGGFNDAAVAESLAEALTMFSSLNGSQTQQNVDGQRHCILIAASNPYPLPTPVYHPHMQNVEQSGNIEAHTANRLSDAETVAKEFPQCSVSLSVICPKQLPKLRAIYNAGKRDPQAADPPIDTSKNPNFLVLISENFIEACAAFNRTGMEISALNQILVEMDMSSVAPVSAPAATFDPAGSVMSQQPISAGSIPSATVNMEPTTVTSVTGPALPHIPTARPTSQLVASLQSASPISVSEEVVPNNEIVNETKPILSGMTQPLRSFSGAAANARILNDVAQAQALVGGTSIGLQSMGGTPILSNMIPGGISSSIPAAPTVLSSGQLAVTSMSGLVPLAGTGQIAQNSVSASSVSIAPSMSGNSNLCVSQLLSNIQGGVSAVMHQNVLSGTGAGMPFGTGTLMSTPRMTQPGHPGMQPLGRNNSTEANIPLSQRQTSATLSSAQSNYVKVWEGDLSGQRQGEPVLITRLQGFRIASASKSLAADWPQTMQIVRLITQEHLNNDVRRLIGKSEIVVFWAMDQHVFLSQLQEKKFCAVIQLPSQAMILSVSDKTCRLIGMLFPENTVVFKPQKLNQQLEAQHPQLEQLLLQQSLPLLQQQRALSRLQQQQPLQQLQQQQHLMPLKRKRNIPLQQQPKIPKLHRQQSPQIQQQQQIPQMQQTEQQQPIIGTCVNQASTGGPRRAQLMSQGQASSRGLPNVP
Length786
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.153
Instability index57.42
Isoelectric point8.66
Molecular weight84451.64
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12224
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.13|      24|      27|     698|     724|       1
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  672-  698 (23.51/ 7.92)	EQLLLQQSL.PL.......LQQQRAL.........srlqqqqpL
  699-  733 (34.41/23.51)	QQLQQQQHLMPLKRKRnipLQQQPKI.........pklhrqqsP
  734-  772 (27.21/10.39)	Q.IQQQQQIPQMQQTE....QQQPIIgtcvnqastggprraqlM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.17|      24|      27|     334|     357|       2
---------------------------------------------------------------------------
  292-  324 (26.61/10.55)	PTTVTS...VTGPALphiptarptSQLVASLQSASP
  334-  357 (41.94/20.68)	NNEIVN...ETKPIL.........SGMTQPLRSFSG
  361-  387 (28.63/11.89)	NARILNdvaQAQALV.........GGTSIGLQSMGG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.77|      20|      27|     396|     422|       3
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  396-  417 (29.38/12.56)	PGGISSSIPA.APtvLSSGQLAV
  506-  526 (26.38/12.91)	PLGRNNSTEAnIP..LSQRQTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.81|      22|      27|     419|     442|       4
---------------------------------------------------------------------------
  419-  433 (19.74/ 7.04)	.................SMSGLVPLAGTGQIA
  434-  461 (26.45/19.24)	QNSVSAssV....siapSMSGNSNLCVSQLLS
  464-  488 (19.62/ 7.57)	QGGVSA..VmhqnvlsgTGAGM.PF.GTG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.38|      95|     465|      93|     195|       5
---------------------------------------------------------------------------
   93-  195 (150.56/109.58)	GFNDAAVAESLAEAL..TMfsSLNGSQTQQ..NVDGQRhciLIAASNP...YPLPTPVYHPHMQNVEQSGNIEAHTAN...RLSD..AETVAKEFPQCSVslsVICPKQL.PKLRA
  559-  666 (134.82/79.37)	GFRIASASKSLAADWpqTM..QIVRLITQEhlNNDVRR...LIGKSEIvvfWAMDQHVFLSQLQEKKFCAVIQLPSQAmilSVSDktCRLIGMLFPENTV...VFKPQKLnQQLEA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12224 with Med25 domain of Kingdom Viridiplantae
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