<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12224

Description mediator of RNA polymerase II transcription subunit 25-like isoform X1
SequenceMMEKQLIVAVEGTAAVGPFWQTIISDYLDKMIRSFTKLEPIEKKPSAGNWQLAMVVFTVHGSHGACLVRRSGWTTDIDMFFQWLSAIPFSGGGFNDAAVAESLAEALTMFSSLNGSQTQQNVDGQRHCILIAASNPYPLPTPVYHPHMQNVEQSGNIEAHTANRLSDAETVAKEFPQCSVSLSVICPKQLPKLRAIYNAGKRDPQAADPPIDTSKNPNFLVLISENFIEACAAFNRTGMEISALNQILVEMDMSSVAPVSAPAATFDPAGSVMSQQPISAGSIPSATVNMEPTTVTSVTGPALPHIPTARPTSQLVASLQSASPISVSEEVVPNNEIVNETKPILSGMTQPLRSFSGAAANARILNDVAQAQALVGGTSIGLQSMGGTPILSNMIPGGISSSIPAAPTVLSSGQLAVTSMSGLVPLAGTGQIAQNSVSASSVSIAPSMSGNSNLCVSQLLSNIQGGVSAVMHQNVLSGTGAGMPFGTGTLMSTPRMTQPGHPGMQPLGRNNSTEANIPLSQRQTSATLSSAQSNYVKVWEGDLSGQRQGEPVLITRLQGFRIASASKSLAADWPQTMQIVRLITQEHLNNDVRRLIGKSEIVVFWAMDQHVFLSQLQEKKFCAVIQLPSQAMILSVSDKTCRLIGMLFPENTVVFKPQKLNQQLEAQHPQLEQLLLQQSLPLLQQQRALSRLQQQQPLQQLQQQQHLMPLKRKRNIPLQQQPKIPKLHRQQSPQIQQQQQIPQMQQTEQQQPIIGTCVNQASTGGPRRAQLMSQGQASSRGLPNVP
Length786
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.153
Instability index57.42
Isoelectric point8.66
Molecular weight84451.64
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
transcription regulator complex	GO:0005667	IBA:GO_Central

GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12224
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.13|      24|      27|     698|     724|       1
---------------------------------------------------------------------------
  672-  698 (23.51/ 7.92)	EQLLLQQSL.PL.......LQQQRAL.........srlqqqqpL
  699-  733 (34.41/23.51)	QQLQQQQHLMPLKRKRnipLQQQPKI.........pklhrqqsP
  734-  772 (27.21/10.39)	Q.IQQQQQIPQMQQTE....QQQPIIgtcvnqastggprraqlM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.17|      24|      27|     334|     357|       2
---------------------------------------------------------------------------
  292-  324 (26.61/10.55)	PTTVTS...VTGPALphiptarptSQLVASLQSASP
  334-  357 (41.94/20.68)	NNEIVN...ETKPIL.........SGMTQPLRSFSG
  361-  387 (28.63/11.89)	NARILNdvaQAQALV.........GGTSIGLQSMGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.77|      20|      27|     396|     422|       3
---------------------------------------------------------------------------
  396-  417 (29.38/12.56)	PGGISSSIPA.APtvLSSGQLAV
  506-  526 (26.38/12.91)	PLGRNNSTEAnIP..LSQRQTSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.81|      22|      27|     419|     442|       4
---------------------------------------------------------------------------
  419-  433 (19.74/ 7.04)	.................SMSGLVPLAGTGQIA
  434-  461 (26.45/19.24)	QNSVSAssV....siapSMSGNSNLCVSQLLS
  464-  488 (19.62/ 7.57)	QGGVSA..VmhqnvlsgTGAGM.PF.GTG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     285.38|      95|     465|      93|     195|       5
---------------------------------------------------------------------------
   93-  195 (150.56/109.58)	GFNDAAVAESLAEAL..TMfsSLNGSQTQQ..NVDGQRhciLIAASNP...YPLPTPVYHPHMQNVEQSGNIEAHTAN...RLSD..AETVAKEFPQCSVslsVICPKQL.PKLRA
  559-  666 (134.82/79.37)	GFRIASASKSLAADWpqTM..QIVRLITQEhlNNDVRR...LIGKSEIvvfWAMDQHVFLSQLQEKKFCAVIQLPSQAmilSVSDktCRLIGMLFPENTV...VFKPQKLnQQLEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12224 with Med25 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EQQQPIIGTCVNQASTGGPRRAQLMSQGQASSRGLPNVP
2) GMPFGTGTLMSTPRMTQPGHPGMQPLGRNNSTEANIPLSQRQ
3) PLKRKRNIPLQQQPKIPKLHRQQSPQIQQQQQIPQMQQ
748
482
709
786
523
746










Molecular Recognition Features






MoRF SequenceStartStop




1) LKRKRNIPLQQQPKIPKLHR
2) PRRAQLMS
710
766
729
773