<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12198

Description E3 ubiquitin-protein ligase RNF216-like isoform X6
SequenceMDSADWRTQLLPDSRQRIVNNITETLKRHLSVTREGGVQELKKIAAGFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPMTNSSNAASSGQNAHDPGNAYFGSEGTAPAGAAVGVLDAADWRIQLLPDSRQSIVNKITETLKRHLPVTGEEGVQELKKIAVRFEEKIYTAAISQPDYLRKISLKMLTMETKSQHPMTNSTNAASSGQNALGPDSCQEREITQGSMKRKRENSGDNVEEHNDQILPTFTCEICTEVVPITMKFNNFHSCNHSFCSKCIERHVEVKIQLRIADIQCPYVDCGKLLDPLVCRTMIPLSIFEEWCDLLCRQAHLGFEKCYCPYQDCGEVIVKECEDVVGKSECPNCRRLICFQCGLPWNVCEENGCSKVNDTLFKELVEQKQWTKCPSCNMYVERIAGCNHMQCRCNFCFCYKCGKSPTAQRRWCRCK
Length445
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.481
Instability index43.75
Isoelectric point7.63
Molecular weight50341.18
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
metal ion binding	GO:0046872	IEA:UniProtKB-KW
transcription coactivator activity	GO:0003713	IEA:InterPro
transferase activity	GO:0016740	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12198
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     391.26|      97|     115|       1|      97|       1
---------------------------------------------------------------------------
    1-   97 (196.08/134.15)	MDSADWRTQLLPDSRQRIVNNITETLKRHLSVTREGGVQELKKIAAGFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPMTNSSNAASSGQNAHDP
  117-  213 (195.18/133.50)	LDAADWRIQLLPDSRQSIVNKITETLKRHLPVTGEEGVQELKKIAVRFEEKIYTAAISQPDYLRKISLKMLTMETKSQHPMTNSTNAASSGQNALGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.00|      20|      58|     352|     372|       2
---------------------------------------------------------------------------
  311-  332 (25.10/ 7.95)	TMIPLSIFEEWCDLLCRQAhlG
  353-  372 (38.91/18.84)	DVVGKSECPNCRRLICFQC..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.10|      31|     127|     245|     280|       4
---------------------------------------------------------------------------
  245-  277 (55.39/38.25)	LPTFTCE..ICTEVVPiTMkFNNF.HSCNHSFCSKC
  373-  406 (51.65/26.57)	LPWNVCEenGCSKVND.TL.FKELvEQKQWTKCPSC
  423-  431 (10.06/ 7.13)	...........................CNFCFCYKC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12198 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) METKSQHPMTNSTNAASSGQNALGPDSCQEREITQGSMKRKRENSGDNVE
2) METKSQNPMTNSSNAASSGQNAHDPGNAYFGSE
189
73
238
105










Molecular Recognition Features






MoRF SequenceStartStop




1) ADWRTQLLPD
2) DYLRKISLKMLTMETK
4
61
13
76