<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12196

Description E3 ubiquitin-protein ligase RNF216-like isoform X5
SequenceMLTMETKSQNPMTNSSNAASSGQNAHDPGNAYFGSEGTAPAGAAVGVLDAADWRIQLLPDSRQSIVNKITETLKRHLSVTRQEGVQELMKIAVGFEEKIYTAATSQPDYQRKISLKMLTMETKSQNPMTNSANAASSGQNAHDPGTTPAGTAAGAMDAVDWRTQLLPDSRQRIVNKITETLKRHLPVTGEEGVQELKKIAVRFEEKIYTAAISQPDYLRKISLKMLTMETKSQHPMTNSTNAASSGQNALGPDSCQEREITQGSMKRKRENSGDNVEEHNDQILPTFTCEICTEVVPITMKFNNFHSCNHSFCSKCIERHVEVKIQLRIADIQCPYVDCGKLLDPLVCRTMIPLSIFEEWCDLLCRQAHLGFEKCYCPYQDCGEVIVKECEDVVGKSECPNCRRLICFQCGLPWNVCEENGCSKVNDTLFKELVEQKQWTKCPSCNMYVERIAGCNHMQCRCNFCFCYKCGKSPTAQRRWCRCK
Length484
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.06
Grand average of hydropathy-0.485
Instability index39.40
Isoelectric point7.36
Molecular weight54225.45
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
metal ion binding	GO:0046872	IEA:UniProtKB-KW
transcription coactivator activity	GO:0003713	IEA:InterPro
transferase activity	GO:0016740	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12196
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     467.26|     107|     107|      38|     144|       1
---------------------------------------------------------------------------
    1-   28 (28.56/14.96)	...............................................................................MLTMETKSQNPMTNSSNAASSGQNAHDP
   38-  144 (219.77/166.22)	TAPAGAAVGVLDAADWRIQLLPDSRQSIVNKITETLKRHLSVTRQEGVQELMKIAVGFEEKIYTAATSQPDYQRKISLKMLTMETKSQNPMTNSANAASSGQNAHDP
  146-  252 (218.93/165.55)	TTPAGTAAGAMDAVDWRTQLLPDSRQRIVNKITETLKRHLPVTGEEGVQELKKIAVRFEEKIYTAAISQPDYLRKISLKMLTMETKSQHPMTNSTNAASSGQNALGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.00|      20|      58|     391|     411|       2
---------------------------------------------------------------------------
  350-  371 (25.10/ 6.05)	TMIPLSIFEEWCDLLCRQAhlG
  392-  411 (38.91/14.36)	DVVGKSECPNCRRLICFQC..G
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      82.47|      10|      40|     334|     343|       3
---------------------------------------------------------------------------
  308-  317 (22.22/10.94)	CNHSFCSKCI
  334-  343 (20.91/ 9.86)	CPYVDCGKLL
  377-  386 (21.32/10.20)	CPYQDCGEVI
  462-  470 (18.02/ 7.48)	CNFCFCYKC.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12196 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) METKSQHPMTNSTNAASSGQNALGPDSCQEREITQGSMKRKRENSGDNVE
2) MLTMETKSQNPMTNSSNAASSGQNAHDPGNAYFGSE
3) RKISLKMLTMETKSQNPMTNSANAASSGQNAHDPGTTPAGTAAGAMDAVDW
228
1
111
277
36
161










Molecular Recognition Features






MoRF SequenceStartStop




NANANA