<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12189

Description mediator of RNA polymerase II transcription subunit 33A-like
SequenceMAAMVSSVQIQSNLWDGVMELTKSAQQKGTDPLMWAIQLSSNLNSAGLSMPSTDVANLLVSHICWANNVPIAWKFLEKALTLRVVPPMFVLALLSTRVIPARRSYPVAYRLYMELLKRYAFSLASLINGPNYQKIMEAINDTLHLYQIFGLQGSESGLIMVEFVFAIVWELLDASLDDEGVMELTAEKKSRWPITSQDMELNNHDAFAGGRAEKHEGLCKMNTVMAIEIIGEFFRDKVTSAILYLARKNMPEHWESFTQNLRLLVSNSSALRNSKNISPEALLQLTSNNHVVLSRKRKTSSQKKFHAVVASGSLASSADQCHGASPSVLWLPIDLFLEDTIDGSQVAATSAAETLTGLVKALQAVNSTTWQDTFLGLWIAALRLVNRVRIHDESLPSIVKLSYLSFLSFLYFPLGKIIGKHVTSLQKKQQDLLSSLQQLVDYEGLLTPPLPAAPLANQAAAKAMIFLSGLRVGSGYFEGMSLNDMPVNCAGNLRHLIVEACIARSILDTSAYLWPGYVKGRCDQVPRSVSAQMPGWSSLMKGSPLTPPMVSSLVSTPASSLAEIEKIYDIAVNGSDDDKISAATILCGASLARGWNIQEHTVLFITRLLSPPVPANYSGTESHLIGYARFLNVLLIGVSSIDCVQIFSLHGLVPQLAGALMPICEAFGSCAPNVTWIVMSEEISSHDIFSNAFTLLLKLWRFDQPPRENVMDVVPVGSRLTPEYLLLVRNSQLASSDDLQKDQSKIKRLSRLSSPLSGEPIFMDSFPKLKLWYRQHQACIGSPLSGLLPGTPVHQIVEALLNFMFRKINRTGQSLAPTTSGSSSSSGPGNEDVFLHLKLPAWDILEAVPFVLDAALTACAHGRLSPRELATGLKDLADFLPASLATIVSYFSAEVTRGIWKLASMNGTDWPSPAANLATVEQQIKKILAATGVNVPSLTVGGNSPATLPLPLAALVSLTITYKLDRSTDRFLNLISPALSNLATACPWPCMPVMVALWAQKVKRWSDFLVFSASRTVFHHNSDAVVQLLRMCFAATLGLTTSCIASNGGVGALLGHGFGSHFSGGISPVAPGILYLRIHRAVRNAMFMTEEVVSLLMHFVRDIASSGLPAEKLEKLKKSKYGMRYGQVSLAAAMTRVKLAASLGASLVWITGGVALVQSLIKETLPSWFISAHGSEPSGGMSGGLVAMLGGYALAYFAVLSGTFAWGVDSSSPASQHRSSILGAHLEFLASALDGKISLGCNKATWKAYVSGFVSLMVGSTPGWMLEVDVDVLKRLSMGLKQWNEEELALALLGSSGIGAMGTAAEMIIEGGFNFVR
Length1317
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy0.223
Instability index45.10
Isoelectric point8.28
Molecular weight142503.58
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12189
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.18|      12|      29|     750|     761|       1
---------------------------------------------------------------------------
  750-  761 (22.16/12.27)	SRLSSPLSGEPI
  782-  793 (23.02/13.09)	SPLSGLLPGTPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.58|      19|      29|     248|     266|       2
---------------------------------------------------------------------------
  248-  266 (35.31/23.88)	KNM.PEHWESFTQNLRLLVS
  275-  294 (27.26/16.72)	KNIsPEALLQLTSNNHVVLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.44|      32|      34|    1174|    1207|       3
---------------------------------------------------------------------------
 1142- 1172 (21.00/ 6.77)	..SLGAS..LVWITGGVALvqsliketlpSWF...IS...A..
 1176- 1207 (59.62/39.31)	EPSGGMSGGLVAMLGGYAL..........AYFA.VLSGTFAWG
 1209- 1240 (45.82/22.43)	DSSSPASQHRSSILGAH.L..........EFLAsALDGKISLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.25|      27|      34|      51|      83|       4
---------------------------------------------------------------------------
   51-   77 (50.25/36.37)	PSTDVANLLVSHICWA.NNVPIAWK.FLE
   86-  114 (40.01/17.30)	PPMFVLALLSTRVIPArRSYPVAYRlYME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.15|      27|      35|     944|     972|       7
---------------------------------------------------------------------------
  944-  972 (38.60/31.54)	SPA......TLPLP.LAALVSLtITYKLDRSTDrFL
  976- 1009 (45.55/27.35)	SPAlsnlatACPWPcMPVMVAL.WAQKVKRWSD.FL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.68|      11|      34|     338|     348|       8
---------------------------------------------------------------------------
  338-  348 (18.87/10.02)	EDTIDGSQVAA
  371-  381 (20.81/11.82)	QDTFLGLWIAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     199.05|      50|     367|     489|     538|       9
---------------------------------------------------------------------------
  489-  538 (94.91/62.62)	CAGNLRHLIVEACIARSILDTSAY.....LWPGYVKGRCDQ.......VPRSVSAQMPGWSS
  619-  666 (57.80/35.00)	..GTESHLI...GYAR.FLNV........LLIGVSSIDCVQifslhglVPQLAGALMPICEA
  670-  707 (46.33/26.46)	CAPNVTWIVMSEEISSHDIFSNAFtlllkLW......RFDQ.......PPR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.28|      16|     160|      16|      33|      10
---------------------------------------------------------------------------
   16-   33 (25.39/23.03)	DGVMELTksAQQKGTDPL
  179-  194 (30.89/20.74)	EGVMELT..AEKKSRWPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.57|      21|      26|     850|     873|      11
---------------------------------------------------------------------------
  850-  873 (23.80/28.56)	FvLDAALtACAHGRLSPrELATGL
  879-  899 (35.76/23.06)	F.LPASL.ATIVSYFSA.EVTRGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.26|      20|     246|    1049|    1069|      16
---------------------------------------------------------------------------
 1025- 1044 (33.06/15.56)	VVQLLRMCFAATLGLTTSCI
 1050- 1069 (35.20/22.92)	VGALLGHGFGSHFSGGISPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12189 with Med33 domain of Kingdom Viridiplantae
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