<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12187

Description mediator of RNA polymerase II transcription subunit 8-like isoform X1
SequenceMEAAQDQQQQQPPRAVEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTSAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVAAQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLPPRMQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length530
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.614
Instability index61.23
Isoelectric point9.32
Molecular weight58183.88
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12187
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.15|      22|      23|     308|     330|       1
---------------------------------------------------------------------------
  308-  329 (45.05/12.15)	QQQSLQQQQQQQQQQQQQLQQQ
  356-  377 (36.10/ 6.05)	RQASMPGLGQLHGQPQMQFSQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.34|      58|      64|      70|     132|       2
---------------------------------------------------------------------------
   73-  130 (93.27/63.30)	NLELFNIVEDIK....KVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAK...REQLLH
  134-  198 (82.07/42.52)	NLSVAAQIEKLKvridMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKiqeQESLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.47|      21|     320|       7|      27|       4
---------------------------------------------------------------------------
    7-   27 (37.47/13.58)	QQQQQPPRAVEGLNPAVQQQL
  330-  349 (37.65/13.68)	QQQLQQRQKIMQL.PQHQQQL
  505-  525 (39.34/14.63)	QQGMMPLQNTPQTHPSFQQQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.90|      17|      17|     403|     419|       5
---------------------------------------------------------------------------
  403-  419 (31.56/15.39)	NQA..NQLNRHLN.QFSSPM
  420-  439 (21.34/ 8.14)	NTAlfNSAQSTPNsQMISNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.41|      14|      17|     274|     288|       6
---------------------------------------------------------------------------
  274-  288 (19.93/11.66)	SPSGTTSFdTTTASP
  294-  307 (25.49/11.43)	SPRSSANM.MNTPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.35|      10|      38|     454|     463|      10
---------------------------------------------------------------------------
  454-  463 (19.59/ 9.97)	FG.ISGGTRNL
  494-  504 (15.75/ 6.69)	FGnMSQNTQNL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12187 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLPPRMQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
235
530










Molecular Recognition Features






MoRF SequenceStartStop




NANANA