<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12186

Description mediator of RNA polymerase II transcription subunit 8-like isoform X3
SequenceMEAAQDQQQQQPPRAVEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTSAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVAAQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLPPRMQCSIWVETILV
Length463
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.492
Instability index60.07
Isoelectric point8.83
Molecular weight50887.00
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12186
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.94|      17|      18|     417|     434|       3
---------------------------------------------------------------------------
  417-  434 (26.01/18.53)	SPMnTALFNSAQSTPNSQ
  437-  453 (31.93/18.20)	SNM.SAMMTSQTLPPRMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.80|      18|      18|     258|     275|       4
---------------------------------------------------------------------------
  240-  257 (27.19/16.18)	SSGSYLKNTSP..FSSSNVN
  258-  275 (26.10/15.25)	SQGALLQASGA..LRAAASP
  276-  295 (24.52/13.89)	SGTTSFDTTTAspLPHVNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.34|      58|      63|      70|     132|       5
---------------------------------------------------------------------------
   73-  130 (93.27/75.02)	NLELFNIVEDIK....KVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAK...REQLLH
  134-  198 (82.07/50.49)	NLSVAAQIEKLKvridMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKiqeQESLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.57|      18|      25|     371|     388|       6
---------------------------------------------------------------------------
  375-  393 (26.49/ 9.28)	SQPLGAQQF.QGRQL..aSGAI
  394-  415 (22.09/ 6.50)	HHGMGQSQLnQANQLnrhLNQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.84|      21|     320|       6|      27|       7
---------------------------------------------------------------------------
    6-   27 (34.87/16.40)	DQQQQ................QPPRAVEGLnPAVQQQL
  313-  349 (29.96/10.13)	QQQQQqqqqqqqqlqqqqqqlQQRQKIMQL.PQHQQQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12186 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQLHGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMT
235
444










Molecular Recognition Features






MoRF SequenceStartStop




NANANA