<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12185

Description mediator of RNA polymerase II transcription subunit 8-like isoform X2
SequenceMEAAQDQQQQQPPRAVEGLNPAVQQQLNLESVKTRAISLFKAISRILEDFDAIARTSAVPKWQDILGQFSMVNLELFNIVEDIKKVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAKREQLLHSMQNLSVAAQIEKLKVRIDMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAKIQEQESLLRTAVNHGEGLRVPGDQRHITSALPGHLVDVLTITDGPQSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLPPRMQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
Length526
PositionHead
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.612
Instability index61.82
Isoelectric point9.32
Molecular weight57748.40
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12185
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.24|      31|     308|       5|      39|       1
---------------------------------------------------------------------------
    5-   35 (52.60/14.22)	QDQQQ...QQPPR..AVEGL.NPAVQ..QQLNLESVKTR
  313-  338 (49.01/12.54)	QQQQQ...QQQQQ..Q.QQL.Q...Q..QQQQLQQ.RQK
  344-  382 (40.63/12.29)	QHQQQllaQQQLRqaSMPGLgQPQMQfsQPLGAQQFQGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     258.95|      54|      55|     201|     254|       2
---------------------------------------------------------------------------
  201-  254 (88.93/41.04)	VN.HGEGLRVPGDQRHITSA.LPGHLVDVLTITDG..P..Q.SFPDS......SGSYLKNTSPFSSS
  256-  311 (80.07/36.26)	VNsQGALLQASGALRAAASP.SGTTSFDTTTASPL..P..HvNSPRS......SANMMNTPSPQQQS
  413-  443 (25.04/ 6.57)	..................SP.MNTALFNS........A..Q.STPNSqmisnmSAMMT......SQT
  444-  502 (64.91/28.08)	LP.PRMQFGISGGTRNLAAAnLSDQMFNMGGNNPGmmPiqQqQQHGT......FGNMSQNTQNLQQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.47|      61|      63|      65|     127|       3
---------------------------------------------------------------------------
   62-  124 (94.47/76.18)	WQDILgqFSMVNLELFNIVEDIK....KVSKAFVVHPKNVNAENAAILPVMLSSKLLPEMEVEDNAK
  125-  189 (94.00/68.63)	REQLL..HSMQNLSVAAQIEKLKvridMIGAACESAEKVIADTRKAYFGTRQGPTLLPTIDKAQAAK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12185 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QSFPDSSGSYLKNTSPFSSSNVNSQGALLQASGALRAAASPSGTTSFDTTTASPLPHVNSPRSSANMMNTPSPQQQSLQQQQQQQQQQQQQLQQQQQQLQQRQKIMQLPQHQQQLLAQQQLRQASMPGLGQPQMQFSQPLGAQQFQGRQLASGAIHHGMGQSQLNQANQLNRHLNQFSSPMNTALFNSAQSTPNSQMISNMSAMMTSQTLPPRMQFGISGGTRNLAAANLSDQMFNMGGNNPGMMPIQQQQQHGTFGNMSQNTQNLQQGMMPLQNTPQTHPSFQQQRPQGQQ
235
526










Molecular Recognition Features






MoRF SequenceStartStop




NANANA