<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12184

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X2
SequenceMDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQELKKIAMRFEDMIHTAATSKQDYLQRFSKMLTKLTKFQYPDSIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNIQNNMASQNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQQQQFQTTQRYLYQQQLHRQMIKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQLTESQPVNSGLYCNRHPIHMLQLSKIPVQRQTLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQASSPLLQQQKELYQLQRATPEASSTSLDSTVLRGNAIGADWQEVYQKIKFMKEMYLSKLNYLYQKIASKMQQLDSLLQRPQNEQIETFKMLKITLGHILLFLRLNKQDIQLSHKEKLLQVEKHIDLFLSSDRPRKPTLSLQQGQLPEALRMQLKVTQHPSPQTDEQNMLASLTKAGPPLQSANSPFVVPSPSTSWDLSPMPGDSVKVSTGLASHIAAGNITHQQADAPDQSVGIGIPEISASPLLAEFTCLDGTHANVSAVVSGKSSVEQSLERLMKVVKNMSPKALNSSISDISSVVSMMDRTAGSAPGNGSRATVGEDLVATTKCRLQATNYSAQDGLPGAKKQKRHRTSDVVSSSGCVNDSFWQLNGSEASESESTSVKIPKPEVIF
Length781
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.677
Instability index66.58
Isoelectric point9.53
Molecular weight86754.14
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12184
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     245.14|      44|      44|     209|     252|       1
---------------------------------------------------------------------------
   95-  159 (37.31/ 7.88)	QYPdsiqpsavtsgQNaH.GPGSctmHSQVNSQAQQlpvpmvaNETQ.TKRPVL..LQNIQNNMASQNC
  209-  249 (67.90/19.47)	..............QR.Q.MQGR...QQQVASQQQQ.......QQFQTTQRYLY..QQQLHRQMIKKKF
  250-  292 (51.97/13.43)	QLG........ntpQS.L.IQHE...QQKQQPQSQE.......EQHQQRQNLL....QPTQRNMHQQ..
  293-  328 (37.51/ 7.95)	QLG..........sQS.N.ISG.........IQQQQ......lTESQPVNSGLYcnRHPIH..M....L
  329-  377 (50.45/12.85)	QLS.......kipvQR.QtLQSA...ATVLPSQRQQ.......SQSQPAQQQMT..PQSQSRPPLGLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.00|      21|      30|     592|     617|       2
---------------------------------------------------------------------------
  560-  597 (25.24/ 7.31)	LASLTKAGP.PLQSANspfvvpspstswdlspmPGDSVK
  602-  624 (29.75/25.43)	LASHIAAGNiTHQQAD................aPDQSVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.24|      27|      30|     692|     718|       3
---------------------------------------------------------------------------
  692-  718 (46.85/24.70)	MDRTAGSA....PG.NGSRATVGEDLVATTKC
  720-  751 (37.39/18.47)	LQATNYSAqdglPGaKKQKRHRTSDVVSSSGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.25|      13|      33|     642|     654|       4
---------------------------------------------------------------------------
  642-  654 (21.65/16.51)	LDGTHANVSAVVS
  678-  690 (20.61/15.34)	LNSSISDISSVVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.55|      16|      51|     384|     405|       5
---------------------------------------------------------------------------
  384-  405 (22.18/21.24)	REMQQsiqassPLLQQQKELYQ
  440-  455 (23.37/10.13)	KFMKE......MYLSKLNYLYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.43|      20|      33|     495|     514|       6
---------------------------------------------------------------------------
  495-  514 (33.05/20.61)	LNKQDIQLSHKEKL.LQVEKH
  529-  549 (29.38/17.44)	LSLQQGQLPEALRMqLKVTQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.45|      10|      17|      65|      75|      10
---------------------------------------------------------------------------
   65-   75 (13.70/15.81)	RFEDMIhTAAT
   83-   92 (17.75/12.63)	RFSKML.TKLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12184 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQL
2) MDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQEL
3) QNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQ
4) SIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNI
5) TLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQ
245
1
157
99
339
308
59
224
150
391










Molecular Recognition Features






MoRF SequenceStartStop




NANANA