<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12183

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X3
SequenceMDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQELKKIAMRFEDMIHTAATSKQDYLQRFSKMLTKLTKFQYPDSIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNIQNNMASQNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQQQQFQTTQRYLYQQQLHRQMIKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQLTESQPVNSGLYCNRHPIHMLQLSKIPVQRQTLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQASSPLLQQQKELYQLQRATPEASSTSLDSTVLRGNAIGADWQEVYQKIKFMKEMYLSKLNYLYQKIASKMQQLDSLLQRPQNEQIETFKMLKITLGHILLFLRLNKQDIQLSHKEKLLQVEKHIDLFLSSDRPRKPTLSLQQGQLPEALRMQLKVQSSMEAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAGPPLQSANSPFVVPSPSTSWDLSPMPGDSVKVSTGLASHIAAGNITHQQADAPDQSVGIGIPEISASPLLAEFTCLDGTHANVSAVVSG
Length679
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.725
Instability index71.13
Isoelectric point9.59
Molecular weight76107.28
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     243.55|      44|      44|     209|     252|       1
---------------------------------------------------------------------------
   95-  159 (36.85/ 8.48)	QYPdsiqpsavtsgQNaH.GPGSctmHSQVNSQAQQlpvpmvaNETQ.TKRPVL..LQNIQNNMASQNC
  209-  249 (68.07/22.34)	..............QR.Q.MQGR...QQQVASQQQQ.......QQFQTTQRYLY..QQQLHRQMIKKKF
  250-  292 (51.60/15.03)	QLG........ntpQS.L.IQHE...QQKQQPQSQE.......EQHQQRQNLL....QPTQRNMHQQ..
  293-  328 (36.40/ 8.28)	QLG..........sQS.N.ISG.........IQQQQ......lTESQPVNSGLYcnRHPIH..M....L
  329-  377 (50.63/14.60)	QLS.......kipvQR.QtLQSA...ATVLPSQRQQ.......SQSQPAQQQMT..PQSQSRPPLGLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.64|      35|     419|     161|     206|       2
---------------------------------------------------------------------------
  161-  199 (53.93/26.00)	SLSPALPPLGNltqATMPNVIGRNSNFQTMQTMPNvDQV
  586-  620 (63.71/22.58)	SLTKAGPPLQS...ANSPFVVPSPSTSWDLSPMPG.DSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.47|      36|      45|     401|     445|       3
---------------------------------------------------------------------------
  401-  422 (25.59/ 6.93)	.............................K..ELYQ............LQRATPEASST......SLDSTV
  423-  490 (33.22/29.90)	LRGNAigadwqevyQKIKF.MKEMylsklN..YLYQkiaskmqqldslLQRPQNEQIETfkmlkiTLGHIL
  493-  535 (41.65/18.97)	LRLNK.........QDIQLsHKEKllqveKhiDLF.............LSSDRPRKPTL......SLQQGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12183 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAG
2) IKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQL
3) MDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQEL
4) QNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQ
5) SIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNI
6) TLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQ
551
245
1
157
99
339
591
308
59
224
150
391










Molecular Recognition Features






MoRF SequenceStartStop




NANANA