<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12182

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X1
SequenceMDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQELKKIAMRFEDMIHTAATSKQDYLQRFSKMLTKLTKFQYPDSIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNIQNNMASQNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQQQQFQTTQRYLYQQQLHRQMIKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQLTESQPVNSGLYCNRHPIHMLQLSKIPVQRQTLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQASSPLLQQQKELYQLQRATPEASSTSLDSTVLRGNAIGADWQEVYQKIKFMKEMYLSKLNYLYQKIASKMQQLDSLLQRPQNEQIETFKMLKITLGHILLFLRLNKQDIQLSHKEKLLQVEKHIDLFLSSDRPRKPTLSLQQGQLPEALRMQLKVQSSMEAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAGPPLQSANSPFVVPSPSTSWDLSPMPGDSVKVSTGLASHIAAGNITHQQADAPDQSVGIGIPEISASPLLAEFTCLDGTHANVSAVVSGKSSVEQSLERLMKVVKNMSPKALNSSISDISSVVSMMDRTAGSAPGNGSRATVGEDLVATTKCRLQATNYSAQDGLPGAKKQKRHRTSDVVSSSGCVNDSFWQLNGSEASESESTSVKIPKPEVIF
Length805
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.04
Grand average of hydropathy-0.686
Instability index67.11
Isoelectric point9.52
Molecular weight89484.14
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     243.55|      44|      44|     209|     252|       1
---------------------------------------------------------------------------
   95-  159 (36.85/ 8.18)	QYPdsiqpsavtsgQNaH.GPGSctmHSQVNSQAQQlpvpmvaNETQ.TKRPVL..LQNIQNNMASQNC
  209-  249 (68.07/20.98)	..............QR.Q.MQGR...QQQVASQQQQ.......QQFQTTQRYLY..QQQLHRQMIKKKF
  250-  292 (51.60/14.23)	QLG........ntpQS.L.IQHE...QQKQQPQSQE.......EQHQQRQNLL....QPTQRNMHQQ..
  293-  328 (36.40/ 7.99)	QLG..........sQS.N.ISG.........IQQQQ......lTESQPVNSGLYcnRHPIH..M....L
  329-  377 (50.63/13.83)	QLS.......kipvQR.QtLQSA...ATVLPSQRQQ.......SQSQPAQQQMT..PQSQSRPPLGLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.26|      32|      73|     576|     607|       3
---------------------------------------------------------------------------
  554-  574 (27.53/10.82)	.....QQNN..........LTKLQH.......NSFSP.....QVTQ....HP
  575-  606 (58.36/30.92)	SPQTDEQNM..........LASLTKAGP.PLQSANSP.....FVVP....SP
  607-  658 (31.26/13.25)	STSWDLSPMpgdsvkvstgLASHIAAGNiTHQQADAPdqsvgIGIPeisaSP
  659-  680 (24.10/ 8.58)	........L..........LAEFTCLDG.T..HANVS.....AVVS....GK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.27|      19|      32|     724|     742|       4
---------------------------------------------------------------------------
  724-  742 (33.36/22.40)	PG.NGSRATVGEDLVATTKC
  756-  775 (26.91/16.66)	PGaKKQKRHRTSDVVSSSGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.45|      10|      17|      65|      75|      10
---------------------------------------------------------------------------
   65-   75 (13.70/13.22)	RFEDMIhTAAT
   83-   92 (17.75/10.55)	RFSKML.TKLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12182 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EAMQQNNLTKLQHNSFSPQVTQHPSPQTDEQNMLASLTKAG
2) IKKKFQLGNTPQSLIQHEQQKQQPQSQEEQHQQRQNLLQPTQRNMHQQQLGSQSNISGIQQQQL
3) MDGNNWRAAQGTAPAAGAMDTADWRTQLQPDSRQRIVNKIMENIKGRLPVSGQEGAQEL
4) QNCVSLSPALPPLGNLTQATMPNVIGRNSNFQTMQTMPNVDQVVPPNMVSNSQRQMQGRQQQVASQQQ
5) SIQPSAVTSGQNAHGPGSCTMHSQVNSQAQQLPVPMVANETQTKRPVLLQNI
6) TLQSAATVLPSQRQQSQSQPAQQQMTPQSQSRPPLGLQQQTNQFPREMQQSIQ
551
245
1
157
99
339
591
308
59
224
150
391










Molecular Recognition Features






MoRF SequenceStartStop




NANANA