<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12178

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X3
SequenceMDGNNWRAAQAQAQAQGGVEGAAAAGPPAGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHNMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTTQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQPQDQQQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSPMLQQPILPAQQHQQQQQQQQQLIAQQANAANLQQNQLIGQQNTMPDVQQRIVGQQNNYSNLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQCQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADWQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVLFLRLNKHDIQPSHKEKRLQIEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQPHMINTVQSGSTVDLGQGNSLNSLQQANLGSLQPNSNILQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYHRQQLMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGMKAGVLQQQQSVGQRVGSHHPQLKSGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKAGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSGSVNDSFWQLNCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVAAATEGGEGTTVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1330
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.775
Instability index72.83
Isoelectric point9.39
Molecular weight146678.74
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12178
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     846.09|      93|      94|     240|     332|       1
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  135-  239 (93.68/16.30)	MQ.......SQVN.SQ...AQQlpvpmvaNQTQ.TRQ.......PLLQQNIQNN....MASTG...................LQNSAS.ltpalppvsnlTQATM....P..NVM.......GQ.....N....ANLQTMQNMQNVG.....QNS..VGNAIGQGM..P.........SNMVANSQRQ
  240-  332 (176.09/38.36)	MQ.G....RQQVV.SQ...QQQ.......QQSQTTQQ.......YLYQQQMHHQ....MMKQK...................FQPGST............QQSMM....Q..SHM.......QQ.....Q...QQQPQDQQQQQQQQ.....QQQ..QQQQQQQNLLQP.........TQIQSSQQTM
  333-  428 (103.27/18.86)	MQpS....SMQST.SLsnlQQN.......QQS.TVQQ.......ST..QSVLHQrsqsVMRQ......................................QQAPMlhqqQ..SPM.......LQ.....Q...PILPAQQHQQQQQQ.....QQQliAQQANAAN.LQQ.........NQLIGQQNTM
  429-  511 (108.79/20.34)	PD.V....QQRIV.G....QQN.......NYSNLQQQ.......QLLNQQNNLQ....NMHQQ....................QLGS..............QSNI....A..GVQ.......QQ.....QltgSQQPGNSGVPSNQH.....PIH..........MLQQ.........SKVPLQQQ.M
  512-  608 (101.09/18.28)	LQ.G....GTTLLpSQ...GQQ.......SQSQPAQ...........Q.QM.......MSQCQ...................SQPGQL............QPPL.........GL.......QQ.....Q...TNQLQREMQQRLQTsgpllQQQ..NVMEQQKQLYQPqraapeassTSLDSTAQTG
  634-  739 (72.08/10.51)	LN.D....LYQKI.AA...KVQ.......Q.....HD.......SLPQRPQTEQ....IEKLKvfkmtlervvlflrlnkhdIQP.SH............KEKRL....QieKHIsfflnsnRP.....R...KPTPPLQGQLPQPS.....MQL..QQ.........P.........QSLDGQGNPP
  740-  838 (85.14/14.01)	MQ.P....VQGSM.AA...MQQ.......NNITNLQHnslsgvsTISNSQPH.......MINT...................VQSGSTvdlgqgnslnslQQANL....G..S.L.......QPnsnilQ...QSLPKQHEQQMLQN.....QQL..RQQYHQ..................R.....Q
  839-  930 (105.95/19.58)	MQ.QqlyhRQQLM.QQ...QQA.......KQQQTAQL.......PAHQMSQLHQ....MNDAN...................DLKMRQ............QMGMK....A..GVL.......QQ.....Q...QSVGQRVGSHHPQL.....KSG..ISSPQIHQALSP............QVTQH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      16|      16|    1233|    1248|       4
---------------------------------------------------------------------------
 1233- 1248 (29.16/16.71)	SPI..QPLRLLVPANYPN
 1250- 1267 (21.32/10.18)	SPVllDKFPVEVSKEYED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.66|      11|      15|      82|      92|       5
---------------------------------------------------------------------------
   82-   92 (18.94/11.53)	KIYTAATSQQD
  100-  110 (17.72/10.17)	KMLTMETKSQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.63|      14|      27|    1037|    1050|       6
---------------------------------------------------------------------------
 1037- 1050 (23.15/14.27)	VSGKSSVEQPLERL
 1066- 1079 (21.48/12.67)	VSDISSVVSMIDRI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12178 with Med15 domain of Kingdom Viridiplantae
Unable to open file!