<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12177

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X1
SequenceMDGNNWRAAQAQAQAQGGVEGAAAAGPPAGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHNMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTTQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQPQDQQQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSPMLQQPILPAQQHQQQQQQQQQLIAQQANAANLQQNQLIGQQNTMPDVQQRIVGQQNNYSNLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQCQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADWQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVLFLRLNKHDIQPSHKEKRLQIEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQPHMINTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNILQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYHRQQLMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGMKAGVLQQQQSVGQRVGSHHPQLKSGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKAGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSGSVNDSFWQLNCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVAAATEGGEGTTVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1362
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.771
Instability index73.16
Isoelectric point9.39
Molecular weight149955.23
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12177
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     896.73|      93|      94|     240|     332|       1
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  135-  239 (95.29/16.37)	MQ...SQV..N.SQ...AQQlpvpmvaNQTQ.TRQP..LLQQNIQNN....MASTG...................LQNSASltpalppvsnlTQATM....P..NVMG...QN....ANLQTMQNMQNVG.....QNS..VGNA..IGQGM..PSNMVANSQRQ
  240-  332 (172.93/37.04)	MQ.GRQQV..V.SQ...QQQ.......QQSQTTQQY..LYQQQMHHQ....MMKQK...................FQPGST...........QQSMM....Q..SHMQ...QQ...QQQPQDQQQQQQQQ.....QQQ..QQQQ..QQQNLLQPTQIQSSQQTM
  333-  428 (99.36/17.46)	MQpSSMQS..T.SLsnlQQN.......QQS.TVQQS..T..QSVLHQrsqsVMRQ.....................................QQAPMlhqqQ..SPML...QQ...PILPAQQHQQQQQQ.....QQQliAQQA..NAAN.LQQNQLIGQQNTM
  429-  511 (108.62/19.92)	PD.VQQRI..V.G....QQN.......NYSNLQQQQ..LLNQQNNLQ....NMHQQ....................QLGS.............QSNI....A..GVQQ...QQltgSQQPGNSGVPSNQH.....PIH............MLQQSKVPLQQQ.M
  512-  599 (100.73/17.82)	LQ.GGTTL..LpSQ...GQQ.......SQSQPA.......QQQM.......MSQCQ...................SQPGQL...........QPPL.........GLQ...QQ...TNQLQREMQQRLQTsgpllQQQ..NVME..QQKQLYQPQRAAPEASST
  629-  739 (78.35/11.86)	MY.LPE....L.ND...LYQ.......KIAAKVQQHdsLPQRPQTEQ....IEKLKvfkmtlervvlflrlnkhdIQP.SH...........KEKRL....QieKHI.sffLN...SNRPRKPTPPLQGQ.....LPQ..PSMQ..LQ....QPQSLDGQGNPP
  740-  809 (82.23/12.90)	MQ.PVQGS..M.AA...MQQ.......NNITNLQ...........HN....SL........................SGVS...........TISNS....Q..PHMI...NT...VQSGS..............TVD..LGQG..NSLNSLQQVATGSLQQNP
  810-  883 (75.01/10.97)	VN.SPQQVniS.SL...NSQ.......SGTNPVQAN..LG.............S.....................LQPNSN.........ilQQSLP....K..QH......E...QQMLQNQQLRQQYH.....QRQ..MQQQlyHRQQLMQ...........
  884-  962 (84.22/13.43)	.............Q...QQA.......KQQQTAQLP..AHQMSQLHQ....MNDAN...................DLKMRQ...........QMGMK....A..GVLQ...QQ...QSVGQRVGSHHPQL.....KSG..ISSP..QIHQALSP...QVTQH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     316.22|     104|     108|    1028|    1134|       3
---------------------------------------------------------------------------
  999- 1069 (75.83/47.44)	.............................................LAPSpMPGDSEKVSAGLALHTTAGN..........imhqQATVASAPAQSLAIGTPG..I...SASP.LLAEFTSLDGT..HANVSAAV
 1070- 1181 (142.19/110.24)	SGKSSVEQP.LE...RLMKVVKNMSpKALNSSVSDISSvvSMIDRIAGS.APGNGSRAAVGEDLVAMTKC............rlQAR..NYFTQDGATGTKK..MkryTTSN.VVSSSGSVNDSfwQLNCSEAS
 1186- 1289 (98.20/65.41)	TATSSVKRPrLEvnhALVEEIQNIN.RQLIDTVVEISD..EGVDPSAVA.AATEG.....GEG.TTV.KCsftavalspnlksqYASAQMSPIQPLRLLVPAnyP...NCSPvLLDKF................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.12|      22|      48|      44|      66|       4
---------------------------------------------------------------------------
   44-   66 (35.80/32.61)	DSRQRIVNKI....................METlKRHLPV..........SGQ
   74-  125 (19.32/10.24)	KIAVRFEEKIytaatsqqdylrkislkmltMET.KSQNPInnsmqpnaasSGQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12177 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQPHMINTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNILQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYHRQQLMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGMKAGVLQQQQSVGQRVGSHHPQLKSGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKAGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
2) MDGNNWRAAQAQAQAQGGVEGAAAAGPPAGAMDSGDWRTQLLPDS
3) METKSQNPINNSMQPNAASSGQNALGPGSHNMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQ
4) NLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQCQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSTSLDSTAQTGNANAADWQEE
5) TTQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQPQDQQQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSPMLQQPILPAQQHQQQQQQQQQLIAQ
695
1
104
444
257
1019
45
251
618
409










Molecular Recognition Features






MoRF SequenceStartStop




NANANA