<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12176

Description mediator of RNA polymerase II transcription subunit 15a-like isoform X2
SequenceMDGNNWRAAQAQAQAQGGVEGAAAAGPPAGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYTAATSQQDYLRKISLKMLTMETKSQNPINNSMQPNAASSGQNALGPGSHNMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQQQQSQTTQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQPQDQQQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSPMLQQPILPAQQHQQQQQQQQQLIAQQANAANLQQNQLIGQQNTMPDVQQRIVGQQNNYSNLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQCQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADWQEEVYQKIKSMREMYLPELNDLYQKIAAKVQQHDSLPQRPQTEQIEKLKVFKMTLERVVLFLRLNKHDIQPSHKEKRLQIEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQPHMINTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNILQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYHRQQLMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGMKAGVLQQQQSVGQRVGSHHPQLKSGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKAGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHTTAGNIMHQQATVASAPAQSLAIGTPGISASPLLAEFTSLDGTHANVSAAVSGKSSVEQPLERLMKVVKNMSPKALNSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGATGTKKMKRYTTSNVVSSSGSVNDSFWQLNCSEASELESTATSSVKRPRLEVNHALVEEIQNINRQLIDTVVEISDEGVDPSAVAAATEGGEGTTVKCSFTAVALSPNLKSQYASAQMSPIQPLRLLVPANYPNCSPVLLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSQPMTLKDIARTWDVCARAVISEYAQQSGGGTFSSKYGSWENCLSAA
Length1359
PositionTail
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.03
Grand average of hydropathy-0.775
Instability index73.16
Isoelectric point9.42
Molecular weight149652.90
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12176
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     876.00|      95|      95|     240|     334|       1
---------------------------------------------------------------------------
  112-  207 (81.00/12.19)	..........I...NNS..MQPNAA..SSGQN.ALGP............gshnMQ..S....QV....N.SQ...AQQlpvpmvaNQTQ.TRQP..LLQ..QNIQNN....MAST.G...................LQNSAS........LTPAL....PpvSNL...TQ...ATMPNVMGQN...ANLQ
  208-  307 (153.75/31.05)	TMQ..NMQNVG...QNS..VGNAIG..QGMPS.NMVA...........nsqrqMQGRQ....QV....V.SQ...QQQ.......QQSQTTQQY..LYQ..QQMHHQ....MMKQ.K...................FQPGST........QQSMM....Q..SHMQ..QQ...QQQPQDQQQQ...QQQQ
  308-  402 (104.11/18.18)	QQQ..QQQQQQ...QNL..LQPTQI..QSSQQ.TMMQ.....................pssmQS....T.SLsnlQQN.......QQS.TVQQS..T....QSVLHQrsqsVMRQ...................................QQAPMlhqqQ..SPML..QQ...PILPAQQHQQ...QQQQ
  403-  495 (118.59/21.93)	QQQliAQQANA...AN...LQQNQL..IGQQN.TMPD..................VQQ....RI....V.G....QQN.......NYSNLQQQQ..LLN..QQNNLQ....NMHQ.Q....................QLGS..........QSNI....A..GVQQ..QQltgSQQPGNSGVP...SNQH
  496-  569 (95.03/15.83)	PIH.............M..LQQSKV..PLQQQ..MLQ..................GGT....TL....LpSQ...GQQ.......SQSQPAQQ.............Q....MMSQcQ...................SQPGQL........QPPL.........GLQ..QQ...TNQLQREMQQ...RLQT
  575-  715 (64.83/ 7.99)	QQQ..NVMEQQ...KQL..YQPQRAapEASSN.STAQtgnanaadwqeevyqkIKSMR....EMylpeL.ND...LYQ.......KIAAKVQQHdsLPQ..RPQTEQ....IEKL.KvfkmtlervvlflrlnkhdIQP.SH........KEKRL....QieKHISffLN...SNRPRKPTPP...LQGQ
  716-  819 (91.72/14.97)	LPQ..PSMQLQ.........QPQSL..DGQGN.PPMQ...........pvqgsMAAMQ....QN....N.IT...NLQ.......HNSLSGVST..ISN..SQPH.......MIN.T...................VQSGSTvdlgqgnsLNSLQ....Q..VATG..SL...QQNPVNSPQQvniSSLN
  820-  882 (88.50/14.13)	SQS..GTNPVQ...ANLgsLQ................................................................PNSNILQQS..LPK..Q..HEQ....QM.......................LQN...........QQLRQ....Q..YHQR..QM...QQQLYHRQQL...MQQQ
  883-  968 (78.48/11.53)	QAK..QQQTAQlpaHQM..SQLHQM..NDANDlKMRQ................QMGMK....AG....V.LQ...QQQ.......SVGQRVGSH..HPQlkSGISSP....QIHQ.A...................LSPQVT........QHPSP....Q..IDQQ..N.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.48|      16|      16|    1262|    1277|       3
---------------------------------------------------------------------------
 1262- 1277 (29.16/21.45)	SPI..QPLRLLVPANYPN
 1279- 1296 (21.32/13.16)	SPVllDKFPVEVSKEYED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.63|      14|      26|    1066|    1079|       4
---------------------------------------------------------------------------
 1066- 1079 (23.15/15.96)	VSGKSSVEQPLERL
 1095- 1108 (21.48/14.17)	VSDISSVVSMIDRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.74|      24|      44|     994|    1021|       6
---------------------------------------------------------------------------
  994- 1021 (39.61/30.36)	TPLAPSP.......MPGdsekVSAG..LA....LHTTAGNI
 1026- 1062 (25.13/10.87)	ATVASAPaqslaigTPG....ISASplLAeftsLDGTHANV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.44|      11|      17|      82|      92|       7
---------------------------------------------------------------------------
   82-   92 (18.45/11.70)	KIYTAATSQQD
  100-  110 (18.99/12.31)	KMLTMETKSQN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12176 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEKHISFFLNSNRPRKPTPPLQGQLPQPSMQLQQPQSLDGQGNPPMQPVQGSMAAMQQNNITNLQHNSLSGVSTISNSQPHMINTVQSGSTVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSLNSQSGTNPVQANLGSLQPNSNILQQSLPKQHEQQMLQNQQLRQQYHQRQMQQQLYHRQQLMQQQQAKQQQTAQLPAHQMSQLHQMNDANDLKMRQQMGMKAGVLQQQQSVGQRVGSHHPQLKSGISSPQIHQALSPQVTQHPSPQIDQQNMLASLTKAGTPLQSTSSPFVVPSPSTPLAPSPMPGDSEKVSAGLALHT
2) MDGNNWRAAQAQAQAQGGVEGAAAAGPPAGAMDSGDWRTQLLPDS
3) METKSQNPINNSMQPNAASSGQNALGPGSHNMQSQVNSQAQQLPVPMVANQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPVSNLTQATMPNVMGQNANLQTMQNMQNVGQNSVGNAIGQGMPSNMVANSQRQMQGRQQVVSQQQ
4) NLQQQQLLNQQNNLQNMHQQQLGSQSNIAGVQQQQLTGSQQPGNSGVPSNQHPIHMLQQSKVPLQQQMLQGGTTLLPSQGQQSQSQPAQQQMMSQCQSQPGQLQPPLGLQQQTNQLQREMQQRLQTSGPLLQQQNVMEQQKQLYQPQRAAPEASSNSTAQTGNANAADWQEE
5) TTQQYLYQQQMHHQMMKQKFQPGSTQQSMMQSHMQQQQQQPQDQQQQQQQQQQQQQQQQQQNLLQPTQIQSSQQTMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRSQSVMRQQQAPMLHQQQSPMLQQPILPAQQHQQQQQQQQQLIAQ
692
1
104
444
257
1016
45
251
615
409










Molecular Recognition Features






MoRF SequenceStartStop




NANANA