<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12175

Description cyclin-dependent kinase E-1-like
SequenceMGDGNTSSRGGNSNSSNRPEWLQHYDLIGKIGEGTYGLVFLAKIKANRSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINQADMSLYLAFDYAEHDLYEIIRHHRDKVNQAINQYTVKSLLWQLLNGLNYLHSNWIIHRDLKPSNILVMGDGEEHGVIKIADFGLARIYQAPLKPLAENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKGTPNPFQLDQLDKIFKVLGHPTPEKWPTLVNLPHWQSDVQRIQGHKYDNPALYSVLHLTPKSPAYDLLSKMLEYDPRKRITAAQALEHEYFRMEPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPPQPVSSGNAASGGMQGPHVMPNRSVPRQMPMVNMQRMPQGMSAYNLASQAGMGAGMNPGNMPMQRGVASQAHQQQMRRKDPGMGMPGYPPQQKSRRF
Length472
PositionKinase
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.08
Grand average of hydropathy-0.468
Instability index41.26
Isoelectric point9.35
Molecular weight52902.15
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12175
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.77|      25|      26|     412|     437|       1
---------------------------------------------------------------------------
  376-  396 (32.16/16.23)	.PQPVSSGNAAS.GGM....qG....PHVMP
  412-  437 (47.53/32.20)	MPQGMSAYNLASQAGM.....GAGMnPGNMP
  439-  465 (38.08/20.58)	QRGVASQ...AHQQQMrrkdpGMGM.PGYPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.20|      18|      31|      77|      95|       2
---------------------------------------------------------------------------
   77-   95 (27.27/28.47)	LREITHENVVKlVNVHINQ
  111-  128 (32.92/28.18)	LYEIIRHHRDK.VNQAINQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.80|      25|      42|     300|     329|       3
---------------------------------------------------------------------------
  300-  329 (32.14/29.91)	LTPKSPAydllSKMLEYdPRKRITAAQALE
  344-  368 (45.66/25.60)	LVPPQPG....EKIVNY.PTRPVDTTTDFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.70|      18|      20|     183|     200|       6
---------------------------------------------------------------------------
  183-  200 (33.03/18.46)	YQAP..LKPLAENGVVVTIW
  201-  220 (27.68/14.47)	YRAPelLLGAKHYTSAVDMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.28|      17|      22|     258|     276|       7
---------------------------------------------------------------------------
  258-  276 (26.99/25.69)	KVLGHPTPEkwPTLVNLPH
  283-  299 (31.30/20.43)	RIQGHKYDN..PALYSVLH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12175 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPLPGRNALVPPQPGEKIVNYPTRPVDTTTDFEGTISLQPPQPVSSGNAASGGMQGPHVMPNRSVPRQMPMVNMQRMPQGMSAYNLASQAGMGAGMNPGNMPMQRGVASQAHQQQMRRKDPGMGMPGYPPQQKSRRF
336
472










Molecular Recognition Features






MoRF SequenceStartStop




1) HQQQMRRKDPGMGMPGYPPQQKSRRF
2) KSIAIKKFK
447
50
472
58