<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12162

Description ATP-dependent DNA helicase Q-like 4A isoform X1
SequenceMRTVNSAGGSMSKDKLPKVNWTQHATAHENFSCQDKFLTSNFLFSLPTQKPCVREQMNARSMACQVRSVTKLETEKAWKLLNSLKLSSKSYTRPGKTLPLTKENKTFSQHSHNTHVPRASDVNYASARCTPLHQGVDENSEYSDTTRYAGNRFPSHSSGVAETGNVVNRQNGADTSVGNNSHSRGIGGISSNHAIGVSKTRESDSTYADGTEEDDILQNIDIDQIVEHYQTNCTPQPSVSRCPPITPVTDSKCLAGSGETNLPPELSLNCNHGLKLGLCPEALDHLQEMKDRLINISNDLLDNVSELSLEQVEMLRQERSQLKLQIQHLEKFLQTASGNEERRMSQFSASTQTSAFQYETPRAVPSRIDPIRLDAQFHGYNESGGFGNWNSSSLSFDVTGGYGLSTAPVEREPYIPKYLDVKYTEGSNDKKWSSRDFPWTKKLEADNKKVFGNPSFRPNQREVINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQDQIMHLLQVNIPAAYLSSNMEWTEQQEILRELNSDVCKYKFLYVTPEKVAKSDVLLRHLESLHTRESLARIVIDEAHCVSQWGHDFRPDYQGLGILKQKFPTVPVLALTATATMSVKEDVVQALGLANCIIFRQSFNRPNLRYSVIPKTKKCLEDIDNFIKKFHFDQCGIIYCLSRMDCERVAEKLQEYGHKAAFYHGSMEGAQRANIQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGLPSSCVLYYSYSDYIRVKHMISQGTVDQNSFGSGYGRSNVAASGRILETNVENLLRMVSYCENDVDCRRLLQLIHFGEKFESTNCRKTCDNCSKIQKCIEKDVTEVAKQLVELVKMTGQKFSSAHVLEVYRGSLSQYVKKHRHESLRLHGAGKHLAKGEASRVLRHLVTEDILVEDVKKSDLYGSVSSVLKVNESKAYNLFSGAQTMRLRLPSSVTQSKLGKFEATPAKGSLTSGKQSPPRTDPSAVPQSPVDTNLSAKLYTALRRLRTLLVKEAGDGVMAYHIFGDATMQQISIKVPRTTDELLDINGIGKVKITKYGDRVLETIEATINEHYKSAKTNSSGNDNTDSGKKRRNSINVQNANSKDEEDFTGSTGRSKKRVLKKQNKNPEVIDYRDLGYFDECMDGDIDFDESMMP
Length1186
PositionUnknown
OrganismNicotiana tabacum (Common tobacco)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Nicotianoideae> Nicotianeae> Nicotiana.
Aromaticity0.07
Grand average of hydropathy-0.541
Instability index42.54
Isoelectric point8.39
Molecular weight132588.27
Publications
PubMed=24807620

Function

Annotated function 
GO - Cellular Component
chromosome	GO:0005694	IBA:GO_Central
cytoplasm	GO:0005737	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IBA:GO_Central
ATP binding	GO:0005524	IEA:UniProtKB-KW
four-way junction helicase activity	GO:0009378	IBA:GO_Central
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
DNA duplex unwinding	GO:0032508	IBA:GO_Central
DNA recombination	GO:0006310	IBA:GO_Central
DNA repair	GO:0006281	IBA:GO_Central
DNA unwinding involved in DNA replication	GO:0006268	IBA:GO_Central
double-strand break repair via homologous recombination	GO:0000724	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12162
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.77|      20|      23|     864|     885|       1
---------------------------------------------------------------------------
  832-  845 (18.27/ 8.80)	....ENDVD..CR.RLLQLIH
  866-  885 (32.14/25.98)	QKCIEKDVTEVAK.QLVELVK
  889-  909 (28.36/14.65)	QKFSSAHVLEVYRgSLSQYVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.07|      15|      23|     124|     138|       2
---------------------------------------------------------------------------
  124-  138 (28.88/19.22)	YASARCTPLHQGVDE
  148-  162 (28.19/18.57)	YAGNRFPSHSSGVAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.26|      11|      23|     928|     940|       3
---------------------------------------------------------------------------
  928-  940 (13.88/16.33)	GEASRVLRhlVTE
  954-  964 (18.38/11.76)	GSVSSVLK..VNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      12|      26|     230|     242|       4
---------------------------------------------------------------------------
  230-  242 (20.57/16.74)	QTNCTPQPSVSrC
  259-  270 (22.99/13.24)	ETNLPPELSLN.C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.81|      14|      23|    1120|    1133|       5
---------------------------------------------------------------------------
 1120- 1133 (23.21/15.68)	GKKRRNSINVQNAN
 1145- 1158 (22.61/15.08)	GRSKKRVLKKQNKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.02|      15|      39|     627|     641|       6
---------------------------------------------------------------------------
  627-  641 (25.97/18.56)	EDV...VQALGLANC.IIF
  663-  681 (19.05/11.54)	EDIdnfIKKFHFDQCgIIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.91|      24|      24|     520|     543|       9
---------------------------------------------------------------------------
  520-  543 (40.73/29.44)	I.PAAYLSSNMEWTEQQEI.LRELNS
  545-  570 (30.18/19.82)	VcKYKFLYVTPEKVAKSDVlLRHLES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.92|      18|      40|     380|     416|      10
---------------------------------------------------------------------------
  380-  399 (30.00/41.78)	YNESGGFGNWnsSSLSFDVT
  423-  440 (36.92/10.58)	YTEGSNDKKW..SSRDFPWT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.73|      23|      40|     767|     792|      11
---------------------------------------------------------------------------
  767-  792 (37.65/36.72)	GRDGLPSSC.VLYYSYSDYIRvkhMIS
  806-  829 (33.08/22.44)	GRSNVAASGrILETNVENLLR...MVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.48|      19|      30|     970|     988|      12
---------------------------------------------------------------------------
  970-  988 (33.83/21.23)	LFSGAQTMRLRLPSSVTQS
 1002- 1020 (35.65/22.79)	LTSGKQSPPRTDPSAVPQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.48|      11|     409|     753|     763|      13
---------------------------------------------------------------------------
  753-  763 (23.62/16.25)	PKSIE....GYHQEC
 1159- 1173 (17.86/10.30)	PEVIDyrdlGYFDEC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12162 with Med34 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQGVDENSEYSDTTRYAGNRFPSHSSGVAETGNVVNRQNGADTSVGNNSHSRGIGGISSNHAIGVSKTRESDSTYADGTEEDDILQNID
2) TINEHYKSAKTNSSGNDNTDSGKKRRNSINVQNANSKDEEDFTGSTGRSKKRVLKKQNK
3) YTRPGKTLPLTKENKTFSQHSHNTHVPRASDVNYASARCTP
133
1099
91
221
1157
131










Molecular Recognition Features






MoRF SequenceStartStop




1) KRVLKK
1149
1154