<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12151

Description mediator of RNA polymerase II transcription subunit 23
SequenceMVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEFIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDDSNLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASSSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSLALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTIENDIITHFSTQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELNPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMQLRERDFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREDNPWIPEDSYYCRLIGRLVDTIAGKSPSPFPNCDWRFNEFPNPAAHALHVTCVELMALSVSGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVINSRSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQDT
Length1220
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.10
Grand average of hydropathy-0.008
Instability index42.95
Isoelectric point6.96
Molecular weight139937.89
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12151
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.72|      26|     127|     486|     513|       1
---------------------------------------------------------------------------
  486-  513 (40.78/29.46)	IKG.FISQLLPTV..FKSHAWGiLHTlLEMF
  612-  640 (44.94/24.13)	IQGtWCKDILQTImsFTPHNWA.SHT.LSCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.78|      19|      89|     972|    1021|       2
---------------------------------------------------------------------------
  315-  333 (37.90/ 9.66)	PVPD....INK.PQ.STHAFAMTCI
  991- 1015 (23.87/ 7.39)	PFPNcdwrFNEfPNpAAHALHVTCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.07|      19|     127|     810|     828|       4
---------------------------------------------------------------------------
  810-  828 (39.81/22.14)	KENSPEHWLQNDWHTK.HMN
  906-  920 (21.07/ 8.43)	....PVTYLYNTLHYY.EMQ
  940-  959 (31.20/15.84)	KDNRPQGWCLSDTYLKcAMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.52|      25|      80|     673|     697|       6
---------------------------------------------------------------------------
  673-  697 (45.33/28.93)	KSMTIENDIITHFSTQGSPPLFLCL
  750-  774 (45.20/28.82)	KCIEILNDMVWKYNIVTLDRLILCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     244|     253|       7
---------------------------------------------------------------------------
  244-  253 (18.69/11.20)	IFFVLFQFAS
  277-  286 (19.45/11.99)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.69|      36|     711|     126|     165|       8
---------------------------------------------------------------------------
  126-  165 (58.60/47.41)	ICGRcsLLPVVNNsgAICNSWKLDP.....ATLRFPLKGLLPY.DK
  864-  905 (56.08/32.57)	VCLR..FLPVFDI..VIHRFLELNPvskslETLLDHLGGLYKFhDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.94|      21|      91|     967|     988|      11
---------------------------------------------------------------------------
  967-  988 (33.84/26.07)	IPEdSYYCRLIGRLVDTIAGKS
 1061- 1081 (39.10/25.11)	LPE.PYWIVLHDRIVSVINSRS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12151 with Med23 domain of Kingdom Metazoa
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