<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12149
Description |
Mediator of RNA polymerase II transcription subunit 15 |
Sequence | MDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSAQLQLQQVAIQQQQQFQQQQVALQQQQQQQQQQQFQAQQNVMQQQFQAVMQQQQQQLQQQQQQQQQQHLINKHLIQQNQQQIQQQQQQLQRMAQLQLQQQQQQQQALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPLVCSRKRKFEEDERQNIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLKSVHRCMTSKLLQLPDKHSVTALLNTWAQSIHQACLSAA |
Length | 678 |
Position | Tail |
Organism | Erinaceus europaeus (Western European hedgehog) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae>
Erinaceus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.787 |
Instability index | 87.57 |
Isoelectric point | 9.40 |
Molecular weight | 76089.39 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364148
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP12149
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
5| 250.39| 31| 31| 81| 111| 1
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81- 111 (58.96/11.44) QLQLQQVAIQQ..QQQ..FQQQQVALQQQQQQQQQ
113- 145 (52.43/ 9.22) QFQAQQNVMQQ..QFQavMQQQQQQLQQQQQQQQQ
173- 195 (43.43/ 6.17) QLQLQQQ..QQ..QQQ........ALQAQPQIQQP
196- 228 (49.10/ 8.09) SMQQSQPPPSQalPQQ..LQQMHHAQHHQPPPQSQ
320- 350 (46.48/ 7.20) LTMLSSPSPGQ..QVQ..TPQSMPPPPQPSPQPGQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 137.90| 26| 28| 248| 274| 2
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231- 248 (29.81/ 6.28) PVAQNQ..PSQ.LPPQSQT........QP
249- 275 (41.17/15.04) LVSQAPTLPGQmLYGQQQPQLKLV..RAP
364- 388 (32.49/ 7.62) APSPSSFLPSP....SPQPSQSPVtaRTP
389- 411 (34.42/ 8.58) QNFSVPS.PGP.LNTPVNPS..SV..MSP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.40| 23| 28| 453| 479| 3
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444- 471 (35.23/20.12) DKNEdrkkdLSKMKSLLDILTDPSKRCP
476- 500 (39.17/15.16) QKCE...iaLEKLKNDMAVPTPPPPPVP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.31| 14| 15| 278| 291| 7
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278- 291 (25.43/ 9.17) VQQPQVQPQVQQVQ
294- 307 (23.88/ 8.06) VQQQTAVPTAQTSQ
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