<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12148

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTAAPQTQLQLQQVAIQQQQQFQQQQVALQQQQQQQQQQQFQAQQNVMQQQFQAVMQQQQQQLQQQQQQQQQQHLINKHLIQQNQQQIQQQQQQLQRMAQLQLQQQQQQQQALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPLVCSRKRKFEEDERQNIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLKSVHRCMTSKLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length732
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.03
Grand average of hydropathy-0.726
Instability index85.30
Isoelectric point9.40
Molecular weight80935.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12148
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     289.48|      31|      31|     152|     182|       1
---------------------------------------------------------------------------
  152-  182 (60.48/14.04)	QLQLQQVAIQQ..Q.QQ..FQQQQVALQQQ....QQQQQQ
  184-  216 (53.64/11.41)	QFQAQQNVMQQ..Q.FQavMQQQQQQLQQQ....QQQQQQ
  244-  266 (45.04/ 8.11)	QLQL.....QQ..Q.QQ...QQQ..ALQAQ....PQIQQP
  267-  299 (47.60/ 9.09)	SMQQSQPPPSQalP.QQ..LQQMHHAQHHQ....PPPQSQ
  305-  340 (40.83/ 6.49)	QNQPSQLPPQS..QtQP..LVSQAPTLPGQmlygQQQPQL
  375-  404 (41.88/ 6.90)	QTS.QIVASGV..Q.VQ..TPQSMPPPPQP....SPQPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.84|      16|      19|      86|     102|       2
---------------------------------------------------------------------------
   86-  102 (26.37/13.56)	QSLTGGPAAGAAgIGMP
  108-  122 (29.17/11.23)	QSLGGMGGLGA..MGQP
  123-  137 (31.29/12.52)	MPLSGQPPPGTS..GMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.56|      21|      28|     470|     492|       4
---------------------------------------------------------------------------
  470-  491 (31.70/26.57)	QAEEQQYLDKLKQL.......SKYIePLR
  500-  527 (29.86/14.54)	NEDRKKDLSKMKSLldiltdpSKRC.PLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.20|      30|     121|     532|     569|       5
---------------------------------------------------------------------------
  435-  459 (31.85/ 7.17)	SPVTARTPQN.FSVPSPGPLntPVNP......
  532-  561 (53.67/20.88)	CEIALEKLKNDMAVPTPPPP..PVPPTKQQYL
  575-  603 (49.68/29.21)	SPVFNHSLYRTF.VPAMTAI..HGPPITAPLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12148 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALQAQPQIQQPSMQQSQPPPSQALPQQLQQMHHAQHHQPPPQSQQPPVAQNQPSQLPPQSQTQPLVSQAPTLPGQMLYGQQQPQLKLVRAPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQTSQIVASGVQVQTPQSMPPPPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMPPHGMAVVSTA
256
70
482
147










Molecular Recognition Features






MoRF SequenceStartStop




NANANA