<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12146

Description cyclin-dependent kinase 19 isoform X1
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYASSSLVKYMEKHKVKPDSRVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQGAAPPQAPPPQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLAPSGANSGGPVISSDYQHSSSRLNYQSSGVQGSSQSQSAQYHPSHQAHRY
Length448
PositionKinase
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.08
Grand average of hydropathy-0.775
Instability index53.75
Isoelectric point8.56
Molecular weight50644.52
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12146
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     284.68|      89|     151|      12|     112|       1
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   12-  112 (135.86/123.72)	ERERVE.DLFEYeGCKVGR.GTYGHVYKARRKDGKDEKEYALKQIEG..TGISMSACREIALLRelKHPNVIALQKVFlshsdRKVwllfDYAEHDLWHIIKFHR
  165-  257 (148.82/101.10)	ERGRVKiDIWAI.GCIFAElLTSEPIFHCRQEDIKTSNPFHHDQLDRifSVMGFPADKDWEDIR..KMPEYPTLQKDF.....RRT....TYASSSLVKYMEKHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.54|      17|      22|     320|     336|       2
---------------------------------------------------------------------------
  320-  336 (32.22/15.87)	PEEKGDKNQQ...QQQNQHQ
  341-  360 (28.32/13.17)	PPQQGAAPPQappPQQNSTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.49|      35|      38|     367|     401|       3
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  367-  401 (62.71/30.84)	GAGAGAGGAGAGLQHS......QDSGLNQVPPNKKPRLAPS
  402-  442 (56.79/27.34)	GANSGGPVISSDYQHSssrlnyQSSGVQGSSQSQSAQYHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.52|      16|      18|     275|     290|       4
---------------------------------------------------------------------------
  275-  290 (28.65/16.81)	DPTKRITSEQALQDPY
  294-  309 (30.88/18.61)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12146 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQGAAPPQAPPPQQNSTQTNGTAGGAGAGAGGAGAGLQHSQDSGLNQVPPNKKPRLAPSGANSGGPVISSDYQHSSSRLNYQSSGVQGSSQSQSAQYHPSHQAHRY
309
448










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHPSHQAHRY
2) NKKPRLAP
3) RLNYQS
437
393
420
448
400
425