<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12145

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMYLALQSLEQDLSKMAVMHWKATNAGPLEKILHGSVGYLSPRSGGHLMNLKYYASPSDLLDDKTASPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLVIGSHPADNKLTPSFSSITGANSVDLPACFFLKFPQPIPVSRAFVQKLQSCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSGSPRMEMSSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNNENPYTDPADLIADATGSPSSDSPTNHFFADGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQTLNTLGVPVLGGDNGETKFKGGSQADTVDFSIITVGGKALGPAELMDHHSGSQSPLLTSGDLGKEKTQKRVKEGNGTSNPGLSGSGLDSKPGKRSRTPSNDGKSKDKPPKRKKADADGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASNSGKMKSSKSEGLSSSKLSSSIYTSQGSSGSGQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPLSKPNISPSHSRPPGSSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSAGMKSSSGLGSSGSLSQKTPSSNSCTTSSSSFSSSSSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQMGVSTNSSHSVSSKHSMLGGEFQGKREKSDKDKSKGSTAGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDKDRDKKKSHSIKPESWSKSPISSDQPLSLTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN
Length1405
PositionMiddle
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.04
Grand average of hydropathy-0.687
Instability index54.99
Isoelectric point8.97
Molecular weight148335.33
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12145
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.80|      22|      22|    1054|    1075|       1
---------------------------------------------------------------------------
  924-  945 (27.04/ 6.55)	HHSHSSSSSSSSSASNSGKMKS
 1052- 1073 (37.75/13.63)	PISSGSGGSHMSGTSSSAGMKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     828.00|      96|      97|    1075|    1170|       2
---------------------------------------------------------------------------
  396-  467 (68.54/15.38)	.......................PG...G..P...ITT.L.......F......N.MSMSIKD....RH.....................esV......GHGEDFSKV.....SQNP....I.LTSLLQ...ITGNGGS.TIGS.S.P.TPPHHTP......................PPV..S...SMAGNT
  468-  561 (73.05/16.99)	KnhPMLMNLLkDNPAQDF..S.TLY...GSSP...LER.QnssgsprM..EMSSG.SNKTKKK....KS.......................S......RL...............P....P.DKPKHQ...TEDDFQR.ELFSMDvD.SQNPIFD......................VNM..T...ADTLD.
  562-  659 (103.97/28.03)	T..PHITPAP.SQCSTPPTTY.PQP...VPHP...QPSiQ.......R..MVRLS.SSDSIGP....DV......................tD......ILSDIAEEA.....SKLP....StSDDCPP...IGTPVRD.SSSS.G.H.SQSALFD......................PDV..F...QTNNNE
  660-  748 (86.79/21.89)	N..P.YTDPA.DLIAD..ATG.SPS...SDSP...TNH.F.......FadGVDFN.PDLLNSQ....SQ.......................S......GFG...........EEYF....D.ESSQSG...DNDDFKGfASQTLN.TlGVPVLGG......................DNG..E.....TKFK
  749-  841 (69.41/15.69)	G..GSQADTV.D...FSIITV.GGK...ALGPaelMDH.H.......S..G.......................................sqS......PLLTSGDLG....kEKTQkrvkE.GNGTSNpglSGSGLDS.KPGKRS.R.TPSNDGK......................SKD..K...PPKRKK
  848-  954 (78.17/18.82)	S..PSHSSSN.RPFTPP..TS.TGG...SKSP.....G.S.......S..GRS.Q.TPPGVATppipKI.......................T......IQIPKGTVM.....VGKP....S.SHSQYT...SSGSVSS.SG...S.K.S......hhshsssssssssasnsgkmksSKS..E...GLSSS.
  955- 1038 (74.42/17.48)	............KLSSSIYTSqGSS...GS.......G.Q............SKN.SSQSGGK....PG.......................SspitkhGL.SSGSSStkmkpQGKP....S.SLMNPL...SKPNISP.SHSRPP.G.S.....S......................DKL..A...SPM..K
 1039- 1126 (83.13/20.59)	................PV.....PG...TP........................P.SSK...A....KSpissgsggshmsgtsssagmkssS......GLGSSGSLS.....QKTP....S.SNSCTT...SSSSFSS.SSSSMS.S.SQNQHGS......................SKG..K...SPSRNK
 1127- 1226 (117.71/32.93)	K..PSLTAVI.DKLKHGVVTS.GPG...GEDP...MDG.Q.......M..GVSTN.SSHSVSS....KH.......................S......MLG.GEFQG.....KREK....S.DKDKSK...GSTAGSS.VDSSKK.T.SESKNVG......................STGvaKiiiSKHDGG
 1227- 1314 (72.82/16.91)	S..PSIKA......K..VTLQ.KPGessGEG....LRP.Q.......M..ASSKNyGSPLISG.stpKH..................ergspS......HS.............KSP....A.YTPQNL...DSESESG.SSIAEK.S.YQNSPSS......................DDG..I...RP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.30|      18|      22|     275|     292|       3
---------------------------------------------------------------------------
  275-  292 (32.49/18.01)	ES.RFSVSFQHPVNDSLVC
  299-  317 (27.81/14.39)	DStHVSCKLYKGLSDALIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.88|      12|      48|     178|     189|       4
---------------------------------------------------------------------------
  178-  189 (24.17/13.53)	KDPDPIPLNHNM
  227-  238 (20.71/10.35)	QHPGRVPLILNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.04|      26|      30|      96|     121|       6
---------------------------------------------------------------------------
   67-   89 (24.46/10.71)	....PIILHEN..NVPRSLGMNASvTIEG
   96-  121 (42.49/24.78)	LPIAPLVIGSH..PADNKLTPSFS.SITG
  127-  154 (39.09/22.12)	LPACFFLKFPQpiPVSRAFVQKLQ.SCTG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12145 with Med1 domain of Kingdom Metazoa
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