<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12144

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVTMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPVNSPATWDFVDPTQRVSCSCSRHKLLKRCAVGSSRPPTISQPGFSAGPSSSASLPPPASSKHKTTERQEKGDKLQKRPLIPFHHRPCVAEELCMEQDPPGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNTSRQMNLNPMDSPHSPVSPLPPTLSPQPRGQETESLDPPSVPVNPALYGSGLELQQLSTMDDRTVLVGQRLPLMAEVSETALYCGVRPSNSDSSDKWWHSYRLPPIDDAEFRPPELQGERCDARMEVNSESTALQRLLAQPNKRFKIWHDKQSQTQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNTAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKIPTVGTEDRPLGKDGRAAVPYPPIADLQRMFPTPPSLEHHPAFSPVMSYKDGLTSETVTALGMMESPMVSIVSAQLTEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFMGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTYLPQLEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISLNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHAWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWEKLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQAPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGGSTNPAASSSTSGSSVPPVSSSASAPVMNQISTTSSSGFSGSVGGQNPSTGANSADRPQGNMGCSGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECALQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNRL
Length1855
PositionMiddle
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy-0.423
Instability index58.12
Isoelectric point5.88
Molecular weight203439.76
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12144
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     209.43|      28|      28|     678|     705|       1
---------------------------------------------------------------------------
  618-  659 (24.51/ 6.44)	PSWAIP.PKIEQLPMPP.AATfirdgynnvpsvGSLADPdylN.T
  660-  687 (39.84/15.74)	PQMNTPVTLNSAAPASN.SGA............GVLPSP...A.T
  688-  715 (46.55/19.81)	PRFSVPTPRTPRTPRTP.RGG............GTASGQ...G.S
 1171- 1198 (32.54/11.31)	PKYQAP.PAAAQGQATPgNAG............PLASNS...G.S
 1209- 1233 (34.77/12.66)	PTSNGGST.NPAASSST.SGS............SV.P.P...V.S
 1234- 1262 (31.23/10.52)	SSASAPVMNQISTTSSS.GFS............GSVGGQ...NpS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.57|      54|     625|    1094|    1154|       2
---------------------------------------------------------------------------
 1094- 1154 (77.40/69.56)	LGQHKPicKVLRDGIMRVGKTVAQKLTDELvSEWFnqpWSS.EENDNHSRLKLYAQVcRHHL
 1727- 1781 (94.17/57.13)	LSREAP..EELKQQPLALGYFVSTAKAENL.PQWF...WSScPQAQNQCPLFLKASL.HHHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.75|      27|      47|      36|      81|       3
---------------------------------------------------------------------------
   23-   53 (42.44/18.85)	HRVWKECILnrtqSKRSQMSTPTLEEEPVNS
   73-  101 (44.31/35.74)	HKLLKRCAV..gsSRPPTISQPGFSAGPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|     771|     795|       4
---------------------------------------------------------------------------
  771-  795 (51.64/37.18)	NFDSC.CICACN..MNIK.GADVGLYIPD
  798-  826 (36.91/24.20)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.35|      44|    1023|     553|     614|       7
---------------------------------------------------------------------------
  491-  548 (65.59/42.24)	KDGRAAvPYP.PIADLQRMFPTPpslehhpafspvmSYKDGLTSETVTALGM........MESPMVS
  562-  614 (69.76/52.80)	EDGLGS.PKPeEIKDFSYVHKVP.............SFQPFMGSSMFAPLKMlpsqcllpLKIPDAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.24|      16|    1024|     265|     285|      10
---------------------------------------------------------------------------
  265-  285 (18.63/27.92)	GVrPSNSDSSDKwwHSYrlPP
 1305- 1320 (32.61/17.63)	GI.PTEPDSADS..QAY..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    1664|    1686|      11
---------------------------------------------------------------------------
 1664- 1686 (24.82/22.18)	SPNNDdmfvDLPFPDDmDNDIGI
 1695- 1712 (34.25/14.95)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.63|      16|      16|     868|     883|      12
---------------------------------------------------------------------------
  868-  883 (28.32/17.09)	SLL..LLLQNQHTQPFAS
  885-  902 (24.31/13.56)	SFLdyISLNNRQTLPCVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.31|      23|      49|     240|     262|      13
---------------------------------------------------------------------------
  240-  262 (40.75/31.26)	MDDRTV....LVGQRLPLMAEV.SE.TAL
  286-  314 (27.56/18.27)	IDDAEFrppeLQGERCDARMEVnSEsTAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.88|      47|     200|     149|     216|      14
---------------------------------------------------------------------------
  113-  163 (78.57/57.91)	KTTERQEKGDKLQK.....RPLIP.FHHRPCVAEELCMeqdpPGQKLGLAGMDSSLE
  179-  233 (69.31/43.01)	RNTSRQMNLNPMDSphspvSPLPPtLSPQPRGQETESL..dpPSVPVNPALYGSGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.04|      23|      26|    1385|    1410|      15
---------------------------------------------------------------------------
 1388- 1410 (44.77/29.91)	YIQYLKSM..AFSVYCQCR...RPLPTQ
 1412- 1439 (30.27/11.22)	HIKSLTGFgpAASIEMTLKnpeRPSPIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.34|      12|      27|    1518|    1529|      16
---------------------------------------------------------------------------
 1518- 1529 (24.58/16.54)	KIGLQKLWEWCI
 1548- 1559 (22.75/14.71)	RLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.88|      15|      21|    1337|    1357|      18
---------------------------------------------------------------------------
 1342- 1357 (24.55/24.33)	NFWLLSLMRCyTEMLD
 1365- 1379 (28.32/10.12)	NSFILQIVPC.QYMLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      16|      17|     412|     427|      20
---------------------------------------------------------------------------
  412-  427 (27.53/19.43)	DGKNAMSIFSSATK.TD
  431-  447 (22.80/14.52)	DNTAGRAGSSSLTQvTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12144 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVGSSRPPTISQPGFSAGPSSSASLPPPASSKHKTTERQEKGDKLQKRPLIP
2) GILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
3) GTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNTAGRAGSSSLTQVTD
4) KYQAPPAAAQGQATPGNAGPLASNSGSAAPSAGSAFNPTSNGGSTNPAASSSTSGSSVPPVSSSASAPVMNQISTTSSSGFSGSVGGQNPSTGANSADRPQGNMGCSGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSA
5) PSLHDLDNIFDNSDDDELGAVSPALRSSKIPTVGTEDRPLGKDGRAAV
6) RPCVAEELCMEQDPPGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNTSRQMNLNPMDSPHSPVSPLPPTLSPQPRGQETESLDPPSVPVNPALYGSGLELQ
7) RVWKECILNRTQSKRSQMSTPTLEEEPVNSPATWD
8) VGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQ
80
1685
381
1172
450
135
24
648
131
1733
447
1313
497
235
58
745










Molecular Recognition Features






MoRF SequenceStartStop




1) YRLPPI
281
286