<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12138

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMAPVQLENHQLVPPGSGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFSSRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKIGTASVHKVTIKIDENDGSKPLQIFHDPPLPASDSKLVERAMKINHLSIEKLLIDSVHARAHQKLQELKVILKGFNANENSSIETALPALVVPILEPCANSECLHIFVDLHSGLFQLMLYGLDQPTLDDMEKSVNDDIKRIILWIQQLKFWLGQQRCKQSIKHLPTICTESLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPDKPTQLSYKYYFMSVSTGDREDSPLTALLLQQFKEDIHDLVPHAKPGKQPRTGTKRKMSEDSCPVEPKKTKRSGETCAFNKVLAHFVAMCDTNMPFVGLRMELTNMEIPHQGLQMEGDGFSHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGSTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGTWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKASVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length1410
PositionTail
OrganismErinaceus europaeus (Western European hedgehog)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Eulipotyphla> Erinaceidae> Erinaceinae> Erinaceus.
Aromaticity0.07
Grand average of hydropathy-0.188
Instability index53.26
Isoelectric point8.86
Molecular weight156440.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12138
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      32|     246|     275|       1
---------------------------------------------------------------------------
  246-  275 (48.89/36.18)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  276-  309 (45.75/33.34)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.17|      23|      32|    1011|    1036|       2
---------------------------------------------------------------------------
 1011- 1033 (43.34/20.75)	KQPGSSGAYPLTSPPTSYHSTVN
 1060- 1078 (28.23/11.98)	...GRAGTWP.GSPQVSGPSPAT
 1119- 1139 (30.84/10.87)	KLPQRSWAASI..PTILTHSALN
 1152- 1170 (20.76/ 9.33)	..PGLAGSY.LCSPLERFLGSV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.40|      24|      24|    1319|    1342|       3
---------------------------------------------------------------------------
 1294- 1320 (30.76/16.11)	FCL..TIPPSAPpiAPPGTPAVVLkSKML
 1321- 1344 (39.94/23.56)	FFL..QLTQKAS..VPPQEPVSII.VPII
 1345- 1368 (26.71/12.82)	YDMasGTTQQAD..IPRQQNSSVA.AP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.89|      35|     508|     581|     626|       4
---------------------------------------------------------------------------
  581-  626 (48.82/53.45)	SPLTALLlqqfkediHDLVPHAkpGKQPRTGTKRKMSEDSCPvEPK
 1084- 1118 (68.07/40.93)	SPANPSL........HSPVPDA..SHSPRAGTSSQTMPTNMP.PPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.97|      49|     508|     657|     756|       5
---------------------------------------------------------------------------
  693-  756 (71.30/115.65)	ISEETQKALDrslldctFRLQGRNNRTW......VAELVFancplngtSTREQGP..SRHVYLTYENLLSEP
 1209- 1265 (72.67/28.26)	LSPKTNQTLQ.......LKVTPENAGQWkpdelqVLEKFF........ETRVAGPpfKANTLIAFTKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.40|      32|      32|      66|      97|       6
---------------------------------------------------------------------------
   66-   97 (51.49/32.57)	LMVLTDLLPRKSDVERKIEIVQFSSRTRQLFV
   99-  130 (52.91/33.66)	LLALVKWANNAGKVEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.87|      26|      32|     511|     540|       9
---------------------------------------------------------------------------
  511-  540 (40.29/35.38)	HLPT..ICTESLQLSNYSTHpignLSKNKLFI
  544-  571 (42.59/26.01)	RLPQyyIVVEMLEVPDKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      32|     135|     145|      10
---------------------------------------------------------------------------
  135-  145 (16.90/10.45)	RLASLARDALV
  168-  178 (20.20/14.07)	RLPTCIRDKII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.61|      11|      24|     767|     778|      11
---------------------------------------------------------------------------
  767-  778 (16.84/14.48)	LNDWSSIaRLYE
  794-  804 (19.77/11.66)	LNIFSEV.RVYN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12138 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGTLDPSSPYTMVSPSGRAGTWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
2) VQLENHQLVPPGSGGGGSSGPASAPAPPPP
970
4
1126
33










Molecular Recognition Features






MoRF SequenceStartStop




NANANA