<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12122

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVTRAAHDSYASLKELVDKCRSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLSSTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCVEDVGTQYALTEDQQKPALKKLDTLVRSKLLQVSIPKEFSDINVSDGTALLRVDGEFKVLITLGYRGHLSLWRILHLELLVGEKNKPVKLEEMRRHVLGDDLERRMAAVDNPFSVMYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSVQNPDSESDSSSLRTPGLKIVYWLDFDKNANVSESGTCPFIKIEPGSDLQIKCLHSSFVIDPLTGKEAEFVLDQSCIDVERLLLRAICCNRYTRLLEIKRELVKNVQVCRTADDVVLQSRMGEPDIEYKQKDEKCCSKDSEGHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALIECEEALNQGSMTAAEVFISLRSKSILHLFASIGRVLGLEVYEHGFNIVKIPKDVSNGSAMLLMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGTDNLSGGDLNQVLRIKKIDIGQMQVHEDEMNLSLVDWGKLRSALPNAIGPNQTSGHEFFSDIRLENSIQIARGHPSGFSSLVDEVFGLEKGSSAAPLSVQNISTGNTSLPSQYGSVPMNIHSLKAGSPSPKWEGGMQIAQVNNVTKASGATSLYSGSLFSSGSVKGPVQSSSVGSIPTGQVRSTAGKKLSASKSEQDLTSPKSPHSVDISSSAAIDEEQLRVLNDTSNEALSGSRSSRLLSPPRPTGSRIPNSRPNGSQVDSFKAAGSCATTPVSQTLESTVSYSTGEDITSKNDKKSRKRTASDMLALIPTLQGFENNPGICKRRKLSDSSGCQLSLAQGAMSSEMIPKTEGYSYGSLIAEVNKGTVPSSIYIVALLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSDDLVTSTDSKTPSSKVSSDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQSGGYISSQGLLLGNSTTNVSQPTSGPGANTVMPTASGLTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLSNSNNPNPGSGSQMMAANGNRINLPISAAMSRTGNQVASLNRVGNALAGSSNLALMTSPVSLRRPPGAVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSQSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQTQVGDVVSAQKPRIELCLENHSGLNVDENSESSSAFRSNIHYDRLHNSVDFALTVVLDSSHVPHVNAAGGAAWLPYCVSVRLRYSFGESSNVSFVAMNGSHGGRACWLRVDDWEKCKQRVARAVEVNGSSAADVSQGRLKLVADSVQRNLHMCIQGLRDGNGVTASSGAT
Length1810
PositionTail
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.06
Grand average of hydropathy-0.179
Instability index42.78
Isoelectric point7.66
Molecular weight196922.85
Publications
PubMed=25384727

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP12122
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.20|      46|      48|     572|     619|       1
---------------------------------------------------------------------------
  572-  619 (73.56/54.85)	PDPSGTDNLSGGDLNQVLRIKKiDIGQMQVHEDEMNlSLVD..WG..KLRSA
  621-  670 (72.64/45.38)	PNAIGPNQTSGHEFFSDIRLEN.SIQIARGHPSGFS.SLVDevFGleKGSSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     294.51|     137|     863|     704|     864|       2
---------------------------------------------------------------------------
  704-  741 (15.80/15.12)	.............................................................................................................................................PSPKWEGGMQ.IAQVNNVtKASGATSLYSGSL.FSSGSVK
  754-  864 (128.98/88.44)	TGQvrsTAGkKLSASKSEQDLTSPK....SPHSVDISSSAAIDE..EQLRVLNDTSNeALSGSRSSRLLSPP....RPTGSRIPNSrpngSQVDSFKAAGSCATTPVSQTLEstVSYSTGE............................................................
 1382- 1460 (75.93/31.21)	TGQ...QAG.GLSNSNNPNPGSGSQmmaaNGNRINLPISAAMSRtgNQVASLNRVGN.ALAGSSNLALMTSPvslrRPPGAVVP.................................................................................................
 1695- 1787 (73.80/28.16)	.................................................................................VVLDS....SHVPHVNAAGGAAWLPYCVSVR..LRYSFGEssnvsfvamngshggracwlRVDDWEKCKQrVARAVEV.NGSSAADVSQGRLkLVADSVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.33|      35|      47|     910|     949|       5
---------------------------------------------------------------------------
  910-  949 (50.57/47.29)	CQLSLAQGAMSSEMipKTEGYSYgslIAEVNKGTVPSSIY
  960-  994 (61.76/40.61)	CSLCIKHARLTSQM..DALDISY...VEEVGLRSGSSNIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.49|      41|     349|    1153|    1198|       6
---------------------------------------------------------------------------
 1153- 1198 (67.67/60.03)	LW.FSFGSSVLARFVVEWESGKEGCTMHVSPDQlwPHTKFledFING
 1504- 1545 (66.82/43.59)	LWlFAQLPDLLKEILGSILKENEGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.21|      45|      50|    1034|    1082|       8
---------------------------------------------------------------------------
 1034- 1082 (72.44/53.90)	ELQKGSNNTPWGSGVRiantSDIDSHIHYDPDGVVLSYQS......VEVDSIKKL
 1085- 1135 (64.77/39.33)	DIQRLANARTFALGMR....KLLGVRAEEKSDDLVTSTDSktpsskVSSDTADKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.17|      53|    1365|     252|     311|       9
---------------------------------------------------------------------------
  252-  311 (73.83/63.67)	SVLHELCVALVMDTVIRQVQVlrqGRWKDA..IRFELISEGHgaSSSSVqNPDSESdSSSLR
 1623- 1677 (87.34/51.44)	SVLREFLKLIAWKKGLSQTQV...GDVVSAqkPRIELCLENH..SGLNV.DENSES.SSAFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12122 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GPVQSSSVGSIPTGQVRSTAGKKLSASKSEQDLTSPKSPHSVDISSSAAIDEEQLRVLNDTSNEALSGSRSSRLLSPPRPTGSRIPNSRPNGSQVDSFKAAGSCA
742
846










Molecular Recognition Features






MoRF SequenceStartStop




NANANA