<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12121

Description mediator of RNA polymerase II transcription subunit 15a isoform X2
SequenceMDPNDWRAQLPPESRQRIINKIIDTLKKHLPFSGHDGMQDLHNIAKRFEEKIFTAATTQPDYLRKISMKMLTMESKSQNTLANTQVGPSNKPTDQGLVLQPQVHNLGQQHSVPLSSQMQSHQQLLSQNVQNNVASQPNLPPVSSLGQTPNQNIVKNSNIQNIPGPNSVGSSISQNSNLQSMFPGSQRTMPGRQQVGPPQQQLQSQSPQQYLYQQQYLKQKLQQQSQMQQQQQQSLMQPNQLQSSQQSTSIQQSMQSMPQQHSQVMRHQQQQTSMVHQQQTPVTQQTILPAQQQQQLMGPQSNAANMQHSQMLGQQNNVGDIQQPQRMLSQQSNLTSLQQQRQQQLINQQNNPANVHQQQLGNNGPGLQQQHLLGPDSGNADMHTSHHSTHMLQQPKVPMQQQSQQNSLNLLLPHSQQSQPLGSQQQLMPQIHTQSTQLQQQLGLQQQQQPNPSQRDMQQRMQTSGSLLQQNVLDQQKQLYQSQRNLSETSATSLDSTTQSAQPGGNDLQEEIYQKIQAMKESYLPDMNEVYQKVANKLQQHDSHPQQSQTDQIDKLRAYKMLLERMMTFVQIPKSSIVPQYKEKLVPYEKQIINLINQSRPRKSMSSVQVGQIPQTHMSSMQQPQSQVSQLQSHENQMNSQLKSTNLQGSMPTMQQNNIATSQHNPLSGVSAGQQNMMNSMQPGANLDSGQGNSVNSLQHVPMNSIQQTPVSTPQLQTSINSLQSQGGANVSQPNSLQSGSSALQHQLKHQEQQMLQNQQFKQFQHRQMVQRQLFQQQQLHHPTKPQLSAQLQTHQMSQLHQMNDINDLKMRQGIGVKPGVFQHLTSGQHSAYSHQQLKQGNAFPVSSPQHLQAPSPQIQQHSSPQVEQQNHLPSKSKVATPLQSSNSPFVGPTPSPPLAPSPMPGESEKSVPCVSSISNAANIGHQQTGVAVAPPQSLAIGTPGISASPLLAEFSGQDGAHGNALAATSGKSTVTEQPLERLINVVKSISSKALSAAVSDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGTNGIKRMKRYTSAIPLSGVLSAGSMDGSIKQLTASEASDLESTATSSVKKRKIEVNHALLGEIRDINHQLIDTVVDISNVDPTPAVAAAEGAEGILVKCSFIAVALSPSLKSQYASAQMSPIQPLRLLVPANYPNCSPILLDKFPVESSKENEDLSAKAKAKFSISLRSLPQPMSLGDIARTWDVCARSVISEHAQQSGGGSFSSKYGTWENCLTTN
Length1264
PositionTail
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.03
Grand average of hydropathy-0.755
Instability index68.42
Isoelectric point9.33
Molecular weight139006.03
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12121
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     674.51|      75|      75|     330|     404|       1
---------------------------------------------------------------------------
  115-  203 (52.27/ 7.72)	.......SSQMQ....S..HQQLLSQnvQ..NNV...A.....sqpNLP......PvS.SLG..QtpN.QNIVKNsniQNIP....GP.NsvgssiS..QNSNLQSmfpgS.QRTMPGRQQVG..PPQ..QQLQ
  204-  262 (79.39/15.86)	SQSP.QQYLYQ.........QQYLKQ..K..................LQ......Q.QsQM.........QQQQQ...QSLM....QP.N......Q......LQS....S.QQSTS.IQQSMQ.SMP..QQHS
  267-  326 (82.01/16.65)	HQ.........Q....Q..QTSMVHQ..Q..QTP.............VT......Q.Q.TI........LPAQQQ...QQLM....GP.Q......S..NAANMQ........HSQMLGQQNNVgDIQ..QPQR
  330-  404 (141.28/34.44)	QQSN.LTSLQQQ....R..QQQLINQ..Q..NNP...A........NVH......Q.Q.QLG..N..N.GPGLQQ...QHLL....GP.D......S..GNADMHT....S.HHSTHMLQQPKV.PMQ..QQSQ
  416-  478 (75.32/14.64)	QQSQpLGS...........QQQLMPQ.....................IHtqstqlQ.Q.QL..........GLQQ...QQ......QP.N......P..SQRDMQQ....RmQTSGSLLQQ.NV..LD..QQKQ
  640-  710 (60.97/10.34)	SQLK.STNLQGSmptmQ..QNNIATS..Q..HNPlsgV........SAG......Q.Q.NMM..N..SmQPGAN.......L....DS.G......Q..GN.............SVNSLQH..V.PMNsiQQTP
  757-  840 (58.45/ 9.58)	QNQQ.FKQFQHR....QmvQRQLFQQ..QqlHHP...TkpqlsaqlQTH......QmS.QLHqmN..D.INDLKM...RQGI....GV.K......P..GVFQHLT....SgQHSAYSHQQLK..........Q
  845-  911 (77.41/15.27)	PVSS.PQHLQAP....S..PQ..IQQ..H..SSP............QVE......Q.Q......N..H.LP..SK...SKVA....TPlQ......S..SNSPFVG....P.TPSPPLAPSP.M.PGE..SEKS
  917-  979 (47.41/ 6.27)	SISN.AANIGHQ................Q..TGV...A........VAP......P.Q.SLA..I..G.TPGISA...SPLLaefsGQ.D......GahGNALAAT....S.GKST.VTEQP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.63|      40|     114|     599|     638|       2
---------------------------------------------------------------------------
  496-  531 (48.93/18.02)	....STTQSAQPGGNDLQEEIYQK......IQAMK.....ESYLPDMNEVY
  532-  573 (52.57/19.96)	QKVANKLQQHDSHPQQSQTDQIDK......LRAYKmllerMMTFV...QIP
  574-  614 (41.56/14.08)	..K.SSI.VPQYK.EKLVPYEKQIinlinqSRPRK.....SMSSVQVGQIP
  615-  638 (32.57/ 9.28)	QTHMSSMQQPQSQVSQLQSHENQM...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.73|      16|      23|     711|     726|       3
---------------------------------------------------------------------------
  711-  726 (28.06/10.42)	VSTPQ.LQTSINSLQSQ
  731-  747 (24.67/ 8.30)	VSQPNsLQSGSSALQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.56|      12|      23|     997|    1010|       4
---------------------------------------------------------------------------
  997- 1010 (15.75/15.18)	AAVSDigSVVSMND
 1023- 1034 (20.81/11.98)	AAVGE..DLVSMTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.98|      22|      47|    1153|    1174|       6
---------------------------------------------------------------------------
 1153- 1174 (37.89/21.20)	LSPSLKSQYASAQMSPIQPLRL
 1202- 1223 (36.09/19.80)	LSAKAKAKFSISLRSLPQPMSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12121 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HRQMVQRQLFQQQQLHHPTKPQLSAQLQTHQMSQLHQMNDINDLKMRQGIGVKPGVFQHLTSGQHSAYSHQQLKQGNAFPVSSPQHLQAPSPQIQQHSSPQVEQQNHLPSKSKVATPLQSSNSPFVGPTPSPPLAPSPMPGESEKSVPCVSSISN
2) KSMSSVQVGQIPQTHMSSMQQPQSQVSQLQSHENQMNSQLKSTNLQGSMPTMQQNNIATSQHNPLSGVSAGQQNMMNSMQPGANLDSGQGNSVNSLQHVPMNSIQQTPVSTPQLQTSINSLQSQGGANVSQPNSLQSGSSALQHQLKHQEQQMLQNQQFKQ
3) MESKSQNTLANTQVGPSNKPTDQGLVLQPQVHNLGQQHSVPLSSQMQSHQQLLSQNVQNNVASQPNLPPVSSLGQTPNQNIVKNSNIQNIPGPNSVGSSISQNSNLQSMFPGSQRTMPGRQQVGPPQQQLQSQSPQ
4) QQQSQMQQQQQQSLMQPNQLQSSQQSTSIQQSMQSMPQQHSQVMRHQQQQTSMVHQQQTPVTQQTILPAQQQQQLMGPQSNAANMQHSQMLGQQNNVGDIQQPQRMLSQQSNLTSLQQQRQQQLINQQNNPANVHQQQLGNNGPGLQQQHLLGPDSGNADMHTSHHSTHMLQQPKVPMQQQSQQNSLNLLLPHSQQSQPLGSQQQLMPQIHTQSTQLQQQLGLQQQQQPNPSQRDMQQRMQTSGSLLQQNVLDQQKQLYQSQRNLSETSATSLDSTTQSAQPGGNDLQEEIYQKIQ
766
603
73
222
920
763
208
517










Molecular Recognition Features






MoRF SequenceStartStop




NANANA