<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12120

Description mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHAGSCTSAVNNSAIGGPSTRDTGRSDSPSLPANFSVSSRRQPPLNPYKLKCDKEPLNSRLGAPDFHPQTSNCPEETLTREYLQSGYRDTVEGLEEAREISLTQVPHFNKNVVLTCKEAIRKRLRAINESRAQKRKAGQVYGVALSGSQLARSGIFPELRPCGEEFQKKWIEGLSQQHKRLRSLADHVPHGYKRASLLDVLIRNNVPLLRATWFIKVTYLNQVQPGSVGISSGTADKIQLSRSDVWTKDVINYLQALLDEFLSKNVSHSASHGRERSPQIPGPLQNKSDPLLSVTDGEGPSLHFRWWYIVRLLQWHHAEGLLHPSLVIDWVFTQLQEKDLLEVWQLLLPIIYGFLETIVLSQTYVRTLAGLALRVVRDPAPGGSDLVDNSRRAYTTCAVIEMLQYLILVVPDTFVALDCFPLPSSVISHTMNDGNFVLKSTEAAGKVKNSSDDFGRIISRIQKHTEDLAKASIPGSPGHCLAKVAKALDKALVLGDLHVAYKFLFDDLCGGTVSEGWVAKVSPCLRLSLKWFGTVNTPLIYSVFFLCEWATCDFRDFRGSPPHDIKFTGRKDLSQVHIAVRLLKMKIKDVKISLKQTNEYHRASRFAKNSGQRPNSNYVGKVSRLKSSSKSTGSSVIFESPGPLHDIIVCWIDQHVVHKGEGSKRLQLFMVELIRAGIFYPLAYVRQLIVSGIMDANVNLVDMERRRRHYRILKQLPGCFIHDVLEESGIVDGVHLKEALQIYLNERRLILRGPLSESHDDASGTDLPPLKRKKYPASIKDEVSGITIDQRNAISTTKNVKDNAKIEELRTAISVLLQLPNCSSNLSATGCDESEGTVRRSIGSQNSKIDPVEGTPGCEECSRTKRQKLSEERNSFVQGNSPVQSDDDDAWWVKKGMKSPEPLKVDQPQKLTKQVTKSRQKNVRKTQSLAQLAASRIEGSQGASTSHVCGSKVNCPHHKTAMDVDGQRSVDIIPTSHFGDIVSIGKALKQLRFVEKRALAIWLLSVVRQVIEETDKNIGKVGQFGRPFSVADDRSSIRWKLGEDELSVMLYLMDISHDLVSAVKFLLWLLPRVLNSPNSTIHSGRNVQMLARNAENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSAMHRAATIVASNGRVSGSGVLAFARYLLRKYGNVASVIEWEKTFKATCDTRLSSELDSCRSVDGELGLPLGVPAGVEDHDDFFRQKISGGRLPSRVGAGMREVVQRNVEEAFRFLFGKDRKLFAAGTLKGLPPVEKWDNGYQIAQQIVMGLIDCIRQTGGAAQEGDPSLVSSAVSAIVGSVGPTLAKIPDFSSGSNHSNITSASNLLNDARCILRMHITCLGLLKEALGERQSRVFDIALATEASTALAGVFTPSKASRSQFQTFPEVHDSSNTISNDMGSSSNKVVVAKTTKIAAAVSALFVGAIIYGVTSLERMVTVLRLKEGLDAVQFVRSTRSTSNGNARSVMAFKMDSSIEVHVHWFRLLIGNCRTICEGLVVELLGEPFIMALSRMQRMLPLNLVFPPAYSIFAFIRWRPFILNATVREDMNQTYQSLIVAITEAIKHLPFRDVCFRDCQGLYDLMSADNSDSDFANLLEFNGSDMHLKLTAFVPLRSRLFLNAIIDCKMPQSIYAKDDGSRISGPGESKVKPTDSGSKLQDMLVHVLDTLQPAKFHWQWVLLRLLLNEQALIEKVENHDVPLADAIKLSSPSPEKAASASENENNFIQILLTRLLVRPDAAPLFAELIHLFGRSLEDSMLLQAKWFLGGQDVLFGRKAIRQRLHNIAVNKKLSVKTQFWEPWGWCSPTTDSLTIKGDNKKFDSTSLEEGEVVEEGTYLKRCQQQVIERALTELLLPCIDQSSDEARNSFATDLVKQLSYIETHITAITGGSKPVGSAPAGVEGQPNKVNNRKNLRTGSAALSRRPTVATDSSPPSPAALRVSMSLRLQLLLRFLPTLCTDREPSVRSTRQFLASVIFRLLGSRVVHQDADISANAVPLPTREAESSSEVASAAFVDSSSQSLFDRLLLVLHGLLSSYPPSWLRPKPSKTSNEPTIDRELLETLQNELDRMQLPDTVRWRIQAAMPVLIPSMRCSLSCQPPSVSNSALMCIQPGTTNPGVNPSSSTIPQRGPALSRVASNVSGKPKRQDNDLEIDPWTLLEDGAGSIPLAGNTASLGSGDHVNIRAASWLKGAVRVRRTDLTYVGAVDDDS
Length2219
PositionKinase
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.06
Grand average of hydropathy-0.216
Instability index48.47
Isoelectric point8.96
Molecular weight245098.55
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12120
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     232.94|     109|     358|     825|     954|       1
---------------------------------------------------------------------------
  825-  906 (77.46/75.84)	.................................................................................................................................................................................................................................................................................CSSNLSA..TGCDESEGTVRRsigsqnskidPVeGTP.GCEECSRTKRQKLS....................EERNSFVQGNspvqsddDDAWWVKKGMKSPEPL
  907-  954 (38.27/19.03)	KVDQPQKLTKQVTKSRQKNVRKTQSLAQLAASRIEGSqgaSTSHVCGS..........................................................................................................................................................................................................................................................................................................................................
 1180- 1266 (70.42/37.04)	................................................kvncphhktamdvdgqrsvdiiptshfgdivsigkalkqlrfvekralaiwllsvvrqvieetdknigkvgqfgrpfsvaddrssirwklgedelsvmlylmdishdlvsavkfllwllprvlnspnstihsgrnvqmlarnaenqvcdvgeafllsslrryenilvaadlipealssamhraativasngrvsgsgvlafaryllrkygnvasviewektfkatCDTRLSSelDSCRSVDGELGL..........PL.GVPaGVEDHDDFFRQKISggrlpsrvgagmrevvqrnvEEAFRFLFGK.......DRKLFAAGTLKGLPPV
 1268- 1312 (46.79/17.57)	KWDNGYQIAQQIVMGLIDCIRQTGGAAQEGDPSLVSS...AVSAIVGS..........................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.97|      37|     358|     263|     327|       2
---------------------------------------------------------------------------
  284-  327 (50.93/67.44)	PGPLQN....KSDPLLsVTDGEGpSLHFRwWYIVRLLQwhhaEGLLHP
  644-  684 (64.04/23.79)	PGPLHDiivcWIDQHV.VHKGEG.SKRLQ.LFMVELIR....AGIFYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      13|     584|     984|     996|       3
---------------------------------------------------------------------------
  984-  996 (22.40/14.27)	IVSIGKALKQLRF
 1567- 1579 (23.32/15.18)	IVAITEAIKHLPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.50|      64|     584|    1386|    1453|       4
---------------------------------------------------------------------------
 1386- 1453 (94.54/74.58)	PSKASRSQFQT...FPEVhdSSNTISNDMGSSSNKV.VVAKTTKIAAAV.SALFVGAIIYGVtsLERMVTVLR
 1972- 2040 (89.96/58.31)	PSVRSTRQFLAsviFRLL..GSRVVHQDADISANAVpLPTREAESSSEVaSAAFVDSSSQSL..FDRLLLVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.03|      38|     354|    1314|    1373|       5
---------------------------------------------------------------------------
 1315- 1354 (59.08/45.54)	PTLAKIPDFSSGsNHSNITSASNLLNDARcILRMHITCLG
 2176- 2213 (65.95/25.63)	PLAGNTASLGSG.DHVNIRAASWLKGAVR.VRRTDLTYVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.10|      26|     354|       3|      28|       6
---------------------------------------------------------------------------
    3-   28 (47.63/25.59)	RYHAGSCTSAVNNSAIGGPSTRDTGR
  369-  394 (44.46/23.40)	RTLAGLALRVVRDPAPGGSDLVDNSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     427.53|     143|    1557|      59|     218|       9
---------------------------------------------------------------------------
   59-  218 (208.32/182.47)	PLNSRLgapdFHPQTSNC..PEETLTREylqSGYRDTVEGLEEAREI.SLTQVPHFNKNVVLTCKEA......IRKRLrAINEsRAQKRKAgQVYGVALSGSqLARSGIFPELRPCGEEFQKKWIEGLsqqHKRLRSLADHVPHGykrASLLDVLIR..NNVPLLRATWFI
 1623- 1776 (219.22/140.81)	PLRSRL....FLNAIIDCkmPQSIYAKD...DGSRISGPGESKVKPTdSGSKLQDMLVHVLDTLQPAkfhwqwVLLRL.LLNE.QALIEKV.ENHDVPLADA.IKLSSPSPEKAASASENENNFIQIL...LTRLLVRPDAAPLF...AELIHLFGRslEDSMLLQAKWFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.03|      28|    1836|      31|      58|      12
---------------------------------------------------------------------------
   31-   58 (53.19/35.83)	SPSLPANF..SVSSRRQPPLNPYKLKC.DKE
 1941- 1971 (41.84/26.28)	SPPSPAALrvSMSLRLQLLLRFLPTLCtDRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12120 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALMCIQPGTTNPGVNPSSSTIPQRGPALSRVASNVSGKPKRQDNDLEID
2) ATGCDESEGTVRRSIGSQNSKIDPVEGTPGCEECSRTKR
3) LSEERNSFVQGNSPVQSDDDDAWWVKKGMKSPEPLKVDQPQKLTKQVTKSRQKNVRKTQSLAQLAASRI
4) SCTSAVNNSAIGGPSTRDTGRSDSPSLPANFSVSSR
5) SKPVGSAPAGVEGQPNKVNNRKNLRTGSAALSRRPTVATDSSPPS
2115
831
872
8
1900
2163
869
940
43
1944










Molecular Recognition Features






MoRF SequenceStartStop




NANANA