<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12119

Description mediator of RNA polymerase II transcription subunit 15a isoform X1
SequenceMDSNNWRPNQGNNPSMDPNDWRAQLPPESRQRIINKIIDTLKKHLPFSGHDGMQDLHNIAKRFEEKIFTAATTQPDYLRKISMKMLTMESKSQNTLANTQVGPSNKPTDQGLVLQPQVHNLGQQHSVPLSSQMQSHQQLLSQNVQNNVASQPNLPPVSSLGQTPNQNIVKNSNIQNIPGPNSVGSSISQNSNLQSMFPGSQRTMPGRQQVGPPQQQLQSQSPQQYLYQQQYLKQKLQQQSQMQQQQQQSLMQPNQLQSSQQSTSIQQSMQSMPQQHSQVMRHQQQQTSMVHQQQTPVTQQTILPAQQQQQLMGPQSNAANMQHSQMLGQQNNVGDIQQPQRMLSQQSNLTSLQQQRQQQLINQQNNPANVHQQQLGNNGPGLQQQHLLGPDSGNADMHTSHHSTHMLQQPKVPMQQQSQQNSLNLLLPHSQQSQPLGSQQQLMPQIHTQSTQLQQQLGLQQQQQPNPSQRDMQQRMQTSGSLLQQNVLDQQKQLYQSQRNLSETSATSLDSTTQSAQPGGNDLQEEIYQKIQAMKESYLPDMNEVYQKVANKLQQHDSHPQQSQTDQIDKLRAYKMLLERMMTFVQIPKSSIVPQYKEKLVPYEKQIINLINQSRPRKSMSSVQVGQIPQTHMSSMQQPQSQVSQLQSHENQMNSQLKSTNLQGSMPTMQQNNIATSQHNPLSGVSAGQQNMMNSMQPGANLDSGQGNSVNSLQHVPMNSIQQTPVSTPQLQTSINSLQSQGGANVSQPNSLQSGSSALQHQLKHQEQQMLQNQQFKQFQHRQMVQRQLFQQQQLHHPTKPQLSAQLQTHQMSQLHQMNDINDLKMRQGIGVKPGVFQHLTSGQHSAYSHQQLKQGNAFPVSSPQHLQAPSPQIQQHSSPQVEQQNHLPSKSKVATPLQSSNSPFVGPTPSPPLAPSPMPGESEKSVPCVSSISNAANIGHQQTGVAVAPPQSLAIGTPGISASPLLAEFSGQDGAHGNALAATSGKSTVTEQPLERLINVVKSISSKALSAAVSDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVSMTNCRLQARNFITQDGTNGIKRMKRYTSAIPLSGVLSAGSMDGSIKQLTASEASDLESTATSSVKKRKIEVNHALLGEIRDINHQLIDTVVDISNVDPTPAVAAAEGAEGILVKCSFIAVALSPSLKSQYASAQMSPIQPLRLLVPANYPNCSPILLDKFPVESSKENEDLSAKAKAKFSISLRSLPQPMSLGDIARTWDVCARSVISEHAQQSGGGSFSSKYGTWENCLTTN
Length1279
PositionTail
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.03
Grand average of hydropathy-0.772
Instability index67.95
Isoelectric point9.33
Molecular weight140718.78
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     671.96|      75|      75|     345|     419|       1
---------------------------------------------------------------------------
  130-  218 (52.28/ 7.97)	.......SSQMQ....S..HQQLLSQnvQ..NNV...A.....sqpNLP......PvS.SLG..QtpN.QNIVKNsniQNIP....GP.NSvgssisQNSNLQSmfpgS.QRTMPGRQQVG..PPQ..QQLQ
  219-  277 (78.92/16.12)	SQSP.QQYLYQ.........QQYLKQ..K..................LQ......Q.QsQM.........QQQQQ...QSLM....QP.NQ..........LQS....S.QQSTS.IQQSMQ.SMP..QQHS
  282-  341 (81.53/16.92)	HQ.........Q....Q..QTSMVHQ..Q..QTP.............VT......Q.Q.TI........LPAQQQ...QQLM....GP.QS......NAANMQ........HSQMLGQQNNVgDIQ..QPQR
  345-  419 (142.06/35.46)	QQSN.LTSLQQQ....R..QQQLINQ..Q..NNP...A........NVH......Q.Q.QLG..N..N.GPGLQQ...QHLL....GP.DS......GNADMHT....S.HHSTHMLQQPKV.PMQ..QQSQ
  431-  493 (75.13/14.96)	QQSQpLGS...........QQQLMPQ.....................IHtqstqlQ.Q.QL..........GLQQ...QQ......QP.NP......SQRDMQQ....RmQTSGSLLQQ.NV..LD..QQKQ
  655-  725 (60.38/10.45)	SQLK.STNLQGSmptmQ..QNNIATS..Q..HNPlsgV........SAG......Q.Q.NMM..N..SmQPGAN.......L....DS.GQ......GN.............SVNSLQH..V.PMNsiQQTP
  772-  855 (57.80/ 9.66)	QNQQ.FKQFQHR....QmvQRQLFQQ..QqlHHP...TkpqlsaqlQTH......QmS.QLHqmN..D.INDLKM...RQGI....GV.KP......GVFQHLT....SgQHSAYSHQQLK..........Q
  860-  926 (76.85/15.49)	PVSS.PQHLQAP....S..PQ..IQQ..H..SSP............QVE......Q.Q......N..H.LP..SK...SKVA....TPlQS......SNSPFVG....P.TPSPPLAPSP.M.PGE..SEKS
  932-  994 (47.01/ 6.35)	SISN.AANIGHQ................Q..TGV...A........VAP......P.Q.SLA..I..G.TPGISA...SPLLaefsGQ.DG....ahGNALAAT....S.GKST.VTEQP............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.56|      12|      23|    1012|    1025|       2
---------------------------------------------------------------------------
 1012- 1025 (15.75/19.83)	AAVSDigSVVSMND
 1038- 1049 (20.81/15.65)	AAVGE..DLVSMTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     175.63|      40|     114|     614|     653|       3
---------------------------------------------------------------------------
  511-  546 (48.93/16.73)	....STTQSAQPGGNDLQEEIYQK......IQAMK.....ESYLPDMNEVY
  547-  588 (52.57/18.53)	QKVANKLQQHDSHPQQSQTDQIDK......LRAYKmllerMMTFV...QIP
  589-  629 (41.56/13.07)	..K.SSI.VPQYK.EKLVPYEKQIinlinqSRPRK.....SMSSVQVGQIP
  630-  653 (32.57/ 8.62)	QTHMSSMQQPQSQVSQLQSHENQM...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.64|      28|      88|       1|      28|       4
---------------------------------------------------------------------------
    1-   28 (57.44/31.91)	MDS..NNWRPNQGNNPSMDPNDWRAQLPPE
   88-  117 (45.20/23.28)	MESksQNTLANTQVGPSNKPTDQGLVLQPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12119 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HRQMVQRQLFQQQQLHHPTKPQLSAQLQTHQMSQLHQMNDINDLKMRQGIGVKPGVFQHLTSGQHSAYSHQQLKQGNAFPVSSPQHLQAPSPQIQQHSSPQVEQQNHLPSKSKVATPLQSSNSPFVGPTPSPPLAPSPMPGESEKSVPCVSSISN
2) KSMSSVQVGQIPQTHMSSMQQPQSQVSQLQSHENQMNSQLKSTNLQGSMPTMQQNNIATSQHNPLSGVSAGQQNMMNSMQPGANLDSGQGNSVNSLQHVPMNSIQQTPVSTPQLQTSINSLQSQGGANVSQPNSLQSGSSALQHQLKHQEQQMLQNQQFKQ
3) MDSNNWRPNQGNNPSMDPNDWRAQLPPESRQRIINKI
4) QQQSQMQQQQQQSLMQPNQLQSSQQSTSIQQSMQSMPQQHSQVMRHQQQQTSMVHQQQTPVTQQTILPAQQQQQLMGPQSNAANMQHSQMLGQQNNVGDIQQPQRMLSQQSNLTSLQQQRQQQLINQQNNPANVHQQQLGNNGPGLQQQHLLGPDSGNADMHTSHHSTHMLQQPKVPMQQQSQQNSLNLLLPHSQQSQPLGSQQQLMPQIHTQSTQLQQQLGLQQQQQPNPSQRDMQQRMQTSGSLLQQNVLDQQKQLYQSQRNLSETSATSLDSTTQSAQPGGNDLQEEIYQKIQ
5) RKISMKMLTMESKSQNTLANTQVGPSNKPTDQGLVLQPQVHNLGQQHSVPLSSQMQSHQQLLSQNVQNNVASQPNLPPVSSLGQTPNQNIVKNSNIQNIPGPNSVGSSISQNSNLQSMFPGSQRTMPGRQQVGPPQQQLQSQSPQ
781
618
1
237
79
935
778
37
532
223










Molecular Recognition Features






MoRF SequenceStartStop




NANANA