<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12096

Description cyclin-dependent kinase E-1 isoform X1
SequenceMGDGSGSRWSRAEWVQQYDLLGKIGEGTYGLVFLARTKTPSPSKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINHADMSLYLAFDYAEHDLYEIIRHHRDKLNHSINQYTVKSLLWQLLNGLSYLHSNWMIHRDLKPSNILVMGEGEEHGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATSNPFQLDQLDKIFKVLGHPTLEKWPSLASLPHWQQDVQHIQGHKYDNTGLYNVVHLSTKSPAYDLLSKMLEYDPRKRITAAQALEHEYFKIEPLPGRNALVPCQLGEKIVNYPTRPVDNTTDLEGTTNLAASQAVTAVSGSMPGAHGSNRSVPRPMNVVGMQRLPSQPMAAYNLTSQAAMGDGMNPGNISKQRGVPQGHPQQLRRKEQMGMPGYPSQQKSRRI
Length461
PositionKinase
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.08
Grand average of hydropathy-0.390
Instability index38.79
Isoelectric point9.16
Molecular weight51548.46
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12096
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.63|      35|      42|     370|     410|       1
---------------------------------------------------------------------------
  370-  405 (60.64/51.09)	SQAVTAvSGSMPGAHGSNRSVPR..PMNV.....VGMQRLPSQ
  414-  455 (55.99/30.93)	SQAAMG.DGMNPGNISKQRGVPQghPQQLrrkeqMGMPGYPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.23|      28|      42|     155|     184|       2
---------------------------------------------------------------------------
  155-  184 (44.60/32.75)	LVMGEGEEHGVVKIADFGLarIYQA..PLKPL
  200-  229 (45.63/27.47)	LLLGAKHYTSAVDMWAVGC..IFAEllTLKPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.15|      21|      38|     302|     323|       3
---------------------------------------------------------------------------
  302-  323 (29.83/20.12)	DLLSKMLEYdPRKRITAAQALE
  342-  362 (36.32/20.17)	QLGEKIVNY.PTRPVDNTTDLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.54|      39|     256|       1|      40|       5
---------------------------------------------------------------------------
    1-   40 (67.88/42.28)	MGDGSGSRW....SRAEWVQQYD.LLGKI..GEGTYGLVFLArTKTP
  254-  299 (59.66/32.79)	LGHPTLEKWpslaSLPHWQQDVQhIQGHKydNTGLYNVVHLS.TKSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12096 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NYPTRPVDNTTDLEGTTNLAASQAVTAVSGSMPGAHGSNRSVPRPMNVVGMQRLPSQPMAAYNLTSQAAMGDGMNPGNISKQRGVPQGHPQQLRRKEQMGMPGYPSQQKSRRI
349
461










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIAIKKFKQ
2) MPGYPSQQKSRRI
44
449
53
461