<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12080

Description mediator of RNA polymerase II transcription subunit 15a isoform X1
SequenceMDNNNWRPNQSNEANMDTSDWRGGLQQESRQRIVNKIMDTLKRHLPVSGQEGLHELQKIAQRFEEKIFTAATSQSDYLRKISLKMLTMETKSQGSMANAPNQGGPSNKPPDPGLVIPPQVHNPGQQHSIPMPNQSQARQQLMQNNIASQSSGLTQTPIQNVGQNNPNMQNIPGQNSVGNTISQNSNMQNMFAGSQRQIQARQQVVPQQQQQSQNSQQFLYQQQIQHQLIRQKFHQQQQQQQNLLQPNQLQSSQQPVIQTSSVMQQAPMMQTSLPSIQHNQQSNNVQQSTQSVLQQHSQVIRQQQPQQTSIIHQQQTPMTQQSILPPQQQQQQQLMGAQGNASNMQHTQILGTQSNNVSDLQQPQQRLLAQQNNLSNLQQQQLINQQNNLSNMHQQLGNNVPGLQPQQVLGPQSGNSGMQTSQHSAHVLQQSQVQIQSQSQPNASNLLPSQVQQSQTQAPQHQLMPQIQSQPAQLQQQLGLQQQPNSLQRDMQQRLQASGPLLQQSTVLDQQKQLYQSQRPLPETSSTSLDSTAQTGQSSGGDWQEEVYQKIKSMKESYLPELNEMYQKIASKLQQQDSLPQQPKSEQLDKLKVFKMMLERIITFLQVSKSNISLSPSFKEKLGSYGKQIINFINTNRPKKNIPGQLPPPHMHSMSQSQSQVTQVQSHENQINSQLQTSNMQGSVATMQQNNMPNMQHNSLSGVSTAQQSKMNSMQPNSNLDSGPGNAVNSLQQVPVSSLQQNPVSAPQQTNVNSLSSQSGVNVIQSNLNPLQQGSSMLQHQQLKQQEQQMLHNQQIKQQYQRQLIQRKQQQIMQQQQQQQLHQTAKQQLPAQLPTHQLQQLHQMNDANDIKMRQGIGVKPGVFQSHLTSSQRSSYPHQQMKGSPFPVSSPQLLQATSPQIPQHSSPQVDQQNHLPSLTKVATPLQSANSPFVVPTPSPPLAPSPMPGDSEKPISGVSLISNAANIGYQQSSGATAPAQSLAIGTPGISASPLLAEFTGPDGALGNAFVSTSGKSTVTEQPIERLIKAVKSMSSKTLCSAVSDIGSVVSMNDRIAGSAPGNGSRAAVGEDLVAMTNCRLQARNFIAQDGANGTRRMKRYTYATPLNVVSSAGSMNDSIKQLTASEVSDLDSTATSRFKMPRVEANHSLLEEIREVNQRLIDTVVDISNEEVDPTAAAAAAEGTEGTIVKCSYNAVALSPSLKSQYASVQMSPIQPLRLLVPTNYPNCSPILLDKFPVESGKENEDLSVKAKSRFSISLRSLSQPMSLGEIARTWDVCARTVISEHAQQSGGGSFSSKYGTWENCLTT
Length1306
PositionTail
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.03
Grand average of hydropathy-0.774
Instability index71.32
Isoelectric point9.38
Molecular weight143906.07
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.75|      16|      16|     419|     434|       2
---------------------------------------------------------------------------
  235-  250 (25.94/ 6.55)	QQQQQQQNLLQPNQLQ
  419-  434 (25.80/ 6.45)	QTSQHSAHVLQQSQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1026.48|     190|     234|     389|     621|       6
---------------------------------------------------------------------------
    7-  190 (151.78/28.27)	..................................................................................RP.NQSNE.........AN..MD....TSDWRGGLQQEsrqRIVNKIM....DTLKRHLPvsgqeGLHEL.QKIAQRFEEKI.FT...............AATSQ..SDYL..RKIS.LKM................................L.....TME..TKS...................QGS..........MANAP...........NQGGpS.........NKPP.................DPGLVI....PPQV..HN.....PG...........qqhsipMPNQS....QarqqlmqnniasqssgltqtpiqnvgqnnP.....NM.....QN.IPGQnsVGNTIS..........QNSNMQNM
  195-  464 (191.52/39.19)	QRQIQA.....RQQ..................VVPQQQQQsqnsqqfLYQqqiqhqlirqkfhqqqqqqqnllqpnqlqsSQQPVIQTSSvmqqapmmqTS..LPSI.QHNQQSN........NVQQSTQ....SV............LQQHSQVIRQQQPQQT.SIihqqqtpmtqqsilpPQQQQ..QQQLmgAQGNASNMqhtqilgtqsnnvsdlqqpqqrllaqqnnlsnLQQQQL....INQQN....................N..........LSNMH...........QQLG.N.........NVPGL................QPQQVL....GPQS..GN.....SGMqtsqhsahvlqqsqvqIQSQS....Q.............................P.....NA.....SNLLPSQ..VQQSQT..........QAPQHQLM
  492-  671 (269.46/56.68)	QQRLQASGPLLQQS..................TVLDQQKQ.......LYQ..............................SQRPLPETSS.........TS..LDSTAQTGQSSGGDWQE...EVYQKIK....SMKESYLP.....ELNEMYQKIASKLQQQD.SL...............PQQPK..SEQL..DKLKVFKM................................MLERIITFLQVSKSNI.......SLSPSF....KEK..........LGSYG...........KQII.NfintnrpkkNIPGQ................LP.........PPH..MH.....S.M..................SQS....Q.............................S......................QVTQV..........QSHENQI.
  672-  838 (162.99/31.82)	NSQLQTSN..MQGSvatmqqnnmpnmqhnslsGVSTAQQS.......KMN..............................SMQP....NS..........N..LDS....G...PGN..........AVN....SLQ................QVPVSSLQQNPvSA...............PQQTN..VNSL..SSQSGVNV................................IQSN.LNPLQQGSSML.......Q.........HQQ..........LKQQE...........QQM................LhnqqikqqyqrqliqrKQQQIM....QQQQ.............................QQQL....H.............................Q.....TA.....KQQLPAQ..L.................PTHQL.
  839- 1061 (132.30/24.65)	...........QQL..................HQMNDAND.....ikMRQ..............................GIGVKPGVFQ.........SH..LTS....SQRSS..........YPH.Q....QMKGSPFP.....VS.......SPQLLQAT.S................PQIPQhsSPQV..DQQNHLP.................................SLTKVATPLQSANSPFvvptpspPLAPSPmpgdSEKpisgvslisnAANIGyqqssgatapaQSLA.I.........GTPGI................SASPLLaeftGPDGalGNafvstSG....................KStvteQ.............................PierliKAvksmsSKTLCSA..VSDIGSvvsmndriagSAPGNG..
 1075- 1203 (118.43/21.41)	NCRLQARNFIAQDG..................ANGTRRMK.......RYT..............................YATPLNVVSS.........AGsmNDSIKQLTASEVSDLDS...TATSRFKmprvEANHSLLE.....EIREVNQR....LI..D.TV................VDIS..NEEV..DPTAAAAA................................AEGTEGTIVKCSYNAV.......ALSPSL....KSQ.............................................................................................................................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12080 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KQLYQSQRPLPETSSTSLDSTAQTGQSSGGDWQEE
2) MDNNNWRPNQSNEANMDTSDWRGGLQQESRQRIVNKIMDTLKRHLPVSGQEGLHELQKIAQRFEEKIFTAA
3) NRPKKNIPGQLPPPHMHSMSQSQSQVTQVQSHENQINSQLQTSNMQGSVATMQQNNMPNMQHNSLSGVSTAQQSKMNSMQPNSNLDSGPGNAVNSLQQVPVSSLQQNPVSAPQQTNVNSLSSQSGVNVIQSNLNPLQQGSSMLQHQQLKQQEQQMLHNQQIKQQYQRQLIQRKQQQIMQQQQQQQLHQTAKQQLPAQLPTHQLQQLHQMNDANDIKMRQGIGVKPGVFQSHLTSSQRSSYPHQQMKGSPFPVSSPQLLQATSPQIPQHSSPQVDQQNHLPSLTKVATPLQSANSPFVVPTPSPPLAPSPMPGDSEKPISG
4) QQPQQTSIIHQQQTPMTQQSILPPQQQQQQQLMGAQGNASNMQHTQILGTQSNNVSDLQQPQQRLLAQQNNLSNLQQQQLINQQNNLSNMHQQLGNNVPGLQPQQVLGPQSGNSGMQTSQHSAHVLQQSQVQIQSQSQPNASNLLPSQVQQSQTQAPQHQLMPQIQSQPAQLQQQLGLQQQPNSLQRDMQQRLQASGPLLQ
5) QQQQQQQNLLQPNQLQSSQQPVIQTSSVMQQAPMMQTSLPSIQHNQQSNNVQQSTQSV
6) RKISLKMLTMETKSQGSMANAPNQGGPSNKPPDPGLVIPPQVHNPGQQHSIPMPNQSQARQQLMQNNIASQSSGLTQTPIQNVGQNNPNMQNIPGQNSVGNTISQNSNMQNMFAGSQRQIQARQQVVPQQQQQS
512
1
636
303
235
79
546
71
955
503
292
212










Molecular Recognition Features






MoRF SequenceStartStop




NANANA