<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12071

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMRQPLLTPYKLKCDKEPLNSRLGPPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVPNFNKGVVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFKRKWIEGLSQQHKRLRSLVDLVPHVRRKSLLEVLIRNNVPLLRATWFIKVTYLNVVRPGSASILSGIGDKTQQTCSELWTKDVVEYLQTLLDEFFSKNSSHFTHNRDRSPQLPYTASLQHRSDQLSVSDGEEPSLHFKWWYIVRLLQWHHTEGLLIPSLIIDWVLRQLQEKQSLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRVIRDPAPGGSDLVDNSRRAYTTSALIEMLRFLILAAPETFVALDCFPLPSSVVSYAINEGSFILKATEAAGKIKSSSEDVCLFKSKGFDAQYQSLAFDHVISCIQERVQDLTKAVKPGYPGQYLAKAAQALDKSLVLGDLHGAYKFLFEDLCDETVSEGWVAKVSHCLRLSLKWFRTVNTSFIYSVFFLCEWATCDFRDFRTAPCDVKFTGRKDLSQVHIAIRLLKMKLRDMQISTRQKSGNTRGHGFSYLGKCSGHQSNRNFVKNASRTKSSSRSMDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGLKRVHLLVVELIQAGIFYPLAYVRQLIVSGIMDMNVVDLERQKRHCRILKQLPKKFVRDALVESGISEGPQLTEALQIYLNERRLILRCSLWENHGNGSNVSISSLKQKQCMSSTKDKASTVSIDQLKSAPSNKASSKSGKDGSGVEDLKTFISALLQLPKSLSNLGSTGLDESQSSVRKPIGSRNKIDLLETTPGCEECRKAKRQKLSEERSLFVQAPSPVLSDDEDTWWAKKGLKSSEPLKVDQPLKPIKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHMCDNKVSCPHHRTAMNGDTARSVDGIQLSECEDIVSIGKALKRLRFVERKEITLWLMSVIRELIEESEKVVGKVSQFGRPFATVDDKSSIRWKLGEDDLSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNVLMLPRNMENQACDVSEAFLLSSLRRYENILAAADLIPETLSSVMQRVAAIMASNGRVSGSGALAFARYLLKKYGNVVSVSEWEKNFKSTCDKRLAFEIESGRSVDGELGLPLGVPAGVEDPDDYFRQKISGGRLPSRVGSGMRDVVQRNVEEAFQYLFGKDRKLFAAGAPKGPAFEKWDNGYQNAQQIVAGLIDCIRQTGGAAQEGDSSLVTSAVSAIVGSVGPTLAKLPDFSAGSNQSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDAGTIPSDVSNNSSKIVVARTTKISAAVSALVVGAIIAGVVSLERIVTILRLKDGLDVVQFVRSTRSNSNGSVRSVGAFKVDCSVEVHVHWFRLLVGNCRTICEGLVVDLLDEPSIVALSRMQRMLSLSLVFPPAYSIFSFVMWRPFVMNANIAFREDMNQLYQSLTMAISDAIKHLPFRNVCLRDCQGLYDLMAANMTDAEFATLLELNGSDIHSKSLAFIPLRARHFLNALIECKMPQSIYTKEEGSRNSGHGESKIDFTDSESTLQDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKMKMHDISLADAIQLSSPSLEKSGASENENNFIEIILTRLLVRPDAAPLFSEVVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIRQRLINIAESKRFSIKTQFSEPWGWCTPCKDPVTLKGDKKKVDSMPLEEGEVVEEGMDVKRSIKGFSPVFDSERSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQIAVVTRGPTKPVNTPATEGQTNKVNSRKNIRSGSPGLARRPTPTPDSSSLSPAALRASISLRVQLLMRFLPIICTDGESSVRSMRYTLASVLLRLLGSRVVHEDAIVNAMQYSPLRKEAESPAEAAFVDSSVECLFDRMLLILHGLLSSSLPSWLRSKPVVKTSNESAREFSGFDREPLEALQNQLDNMQLPDTIRWRIQAAMPVLPFTIRCHFSCQLPTVPTSALASLQPNTTNSGFNSSSSTVPQRNPVPSSRTTASGKSKQQENDLDIDPWMLLEDGAGSCPSANNTNIIGSGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2216
PositionKinase
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.07
Grand average of hydropathy-0.220
Instability index50.65
Isoelectric point8.84
Molecular weight246337.64
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12071
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     323.48|     107|     375|     399|     512|       1
---------------------------------------------------------------------------
  399-  512 (168.68/126.48)	KATEAAGKIKSSSEDVCLFKSKGFD.....AQYQSLAFDHVISCIQERVQDLTKA.VKPGYPGQYLAKAA..QALDKSLVLgdLHGAYKFLFEDlcDEtvsEGWVA....KVSHCLRLS..LKWFRTV
  779-  899 (154.80/97.46)	KASSKSGKDGSGVEDLKTFISALLQlpkslSNLGSTGLDESQSSVRKPIGSRNKIdLLETTPGCEECRKAkrQKLSEERSL..FVQAPSPVLSD..DE...DTWWAkkglKSSEPLKVDqpLKPIKQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.41|      61|     379|    1612|    1680|       2
---------------------------------------------------------------------------
 1612- 1680 (86.78/94.89)	NALIEcKMPQSIYTKEEGSrnsghgESKIDFTDSE.STLQDKLVDVLDALQPAKFHwQWVELRLLL...NEQA
 1992- 2056 (90.62/68.61)	DAIVN.AMQYSPLRKEAES......PAEAAFVDSSvECLFDRMLLILHGLLSSSLP.SWLRSKPVVktsNESA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.25|      28|     218|     928|     956|       8
---------------------------------------------------------------------------
  928-  956 (49.82/39.03)	STSHMCDN.KVSCpHHRTAMNGDTARSVDG
 1149- 1177 (46.44/30.36)	SVSEWEKNfKSTC.DKRLAFEIESGRSVDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12071 with Med12 domain of Kingdom Viridiplantae
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