<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12070

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMQRYHAGSCTSAVNNTAVGGQSTRDIGRTDSSSLPANFPLSSRRQPLLTPYKLKCDKEPLNSRLGPPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVPNFNKGVVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFKRKWIEGLSQQHKRLRSLVDLVPHVRRKSLLEVLIRNNVPLLRATWFIKVTYLNVVRPGSASILSGIGDKTQQTCSELWTKDVVEYLQTLLDEFFSKNSSHFTHNRDRSPQLPYTASLQHRSDQLSVSDGEEPSLHFKWWYIVRLLQWHHTEGLLIPSLIIDWVLRQLQEKQSLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRVIRDPAPGGSDLVDNSRRAYTTSALIEMLRFLILAAPETFVALDCFPLPSSVVSYAINEGSFILKATEAAGKIKSSSEDVCLFKSKGFDAQYQSLAFDHVISCIQERVQDLTKAVKPGYPGQYLAKAAQALDKSLVLGDLHGAYKFLFEDLCDETVSEGWVAKVSHCLRLSLKWFRTVNTSFIYSVFFLCEWATCDFRDFRTAPCDVKFTGRKDLSQVHIAIRLLKMKLRDMQISTRQKSGNTRGHGFSYLGKCSGHQSNRNFVKNASRTKSSSRSMDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGLKRVHLLVVELIQAGIFYPLAYVRQLIVSGIMDMNVVDLERQKRHCRILKQLPKKFVRDALVESGISEGPQLTEALQIYLNERRLILRCSLWENHGNGSNVSISSLKQKQCMSSTKDKASTVSIDQLKSAPSNKASSKSGKDGSGVEDLKTFISALLQLPKSLSNLGSTGLDESQSSVRKPIGSRNKIDLLETTPGCEECRKAKRQKLSEERSLFVQAPSPVLSDDEDTWWAKKGLKSSEPLKVDQPLKPIKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHMCDNKVSCPHHRTAMNGDTARSVDGIQLSECEDIVSIGKALKRLRFVERKEITLWLMSVIRELIEESEKVVGKVSQFGRPFATVDDKSSIRWKLGEDDLSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNVLMLPRNMENQACDVSEAFLLSSLRRYENILAAADLIPETLSSVMQRVAAIMASNGRVSGSGALAFARYLLKKYGNVVSVSEWEKNFKSTCDKRLAFEIESGRSVDGELGLPLGVPAGVEDPDDYFRQKISGGRLPSRVGSGMRDVVQRNVEEAFQYLFGKDRKLFAAGAPKGPAFEKWDNGYQNAQQIVAGLIDCIRQTGGAAQEGDSSLVTSAVSAIVGSVGPTLAKLPDFSAGSNQSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDAGTIPSDVSNNSSKIVVARTTKISAAVSALVVGAIIAGVVSLERIVTILRLKDGLDVVQFVRSTRSNSNGSVRSVGAFKVDCSVEVHVHWFRLLVGNCRTICEGLVVDLLDEPSIVALSRMQRMLSLSLVFPPAYSIFSFVMWRPFVMNANIAFREDMNQLYQSLTMAISDAIKHLPFRNVCLRDCQGLYDLMAANMTDAEFATLLELNGSDIHSKSLAFIPLRARHFLNALIECKMPQSIYTKEEGSRNSGHGESKIDFTDSESTLQDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKMKMHDISLADAIQLSSPSLEKSGASENENNFIEIILTRLLVRPDAAPLFSEVVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIRQRLINIAESKRFSIKTQFSEPWGWCTPCKDPVTLKGDKKKVDSMPLEEGEVVEEGMDVKRSIKGFSPVFDSERSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQIAVVTRGPTKPVNTPATEGQTNKVNSRKNIRSGSPGLARRPTPTPDSSSLSPAALRASISLRVQLLMRFLPIICTDGESSVRSMRYTLASVLLRLLGSRVVHEDAIVNAMQYSPLRKEAESPAEAAFVDSSVECLFDRMLLILHGLLSSSLPSWLRSKPVVKTSNESAREFSGFDREPLEALQNQLDNMQLPDTIRWRIQAAMPVLPFTIRCHFSCQLPTVPTSALASLQPNTTNSGFNSSSSTVPQRNPVPSSRTTASGKSKQQENDLDIDPWMLLEDGAGSCPSANNTNIIGSGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2258
PositionKinase
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.07
Grand average of hydropathy-0.228
Instability index51.24
Isoelectric point8.87
Molecular weight250687.27
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12070
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      15|      18|     485|     499|       1
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  485-  499 (28.63/18.24)	QDLTKAVKPG.YPGQY
  505-  520 (21.54/11.76)	QALDKSLVLGdLHGAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.41|      61|     375|    1654|    1722|       2
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 1654- 1722 (86.78/62.47)	NALIEcKMPQSIYTKEEGSrnsghgESKIDFTDSE.STLQDKLVDVLDALQPAKFHwQWVELRLLL...NEQA
 2034- 2098 (90.62/45.14)	DAIVN.AMQYSPLRKEAES......PAEAAFVDSSvECLFDRMLLILHGLLSSSLP.SWLRSKPVVktsNESA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.17|      88|     606|    1299|    1395|       3
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 1299- 1395 (132.97/113.82)	QQIVAGLIDCIRQTGGAAQEGDSSLVTSAVSAIVGSvgPTLAKLPDFSAGSNQ.SNMSL.ATSSLnYAKCILR.MHITClcllkeALGERQSRVFEIALA
 1929- 2019 (138.19/93.70)	QQIAVVTRGPTKPVNTPATEGQTNKVNSRKNIRSGS..PGLARRPTPTPDSSSlSPAALrASISL.RVQLLMRfLPIIC......TDGESSVRSMRYTLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.10|      36|     606|    1199|    1234|       4
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 1199- 1234 (63.66/49.02)	F.KSTCDKRLAFEIESGR.SVDGELGLPLGVPAGVEDP
 1805- 1842 (60.44/46.05)	FgRKTIRQRLINIAESKRfSIKTQFSEPWGWCTPCKDP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.89|      21|     379|     441|     461|       5
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  441-  461 (35.45/23.17)	KATEAAGKIKSSSEDVCLFKS
  821-  841 (35.44/23.17)	KASSKSGKDGSGVEDLKTFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.22|      74|     745|     315|     394|       6
---------------------------------------------------------------------------
  315-  394 (117.56/92.14)	LQWHHTEGLLIPSLIIDWVLRQLQEKQSLEIWqlLLPIVYGFLEIVVLSQTYVRTLAgvalRVIRDPAPGGSD..LVDNSRR
 1063- 1138 (121.66/80.23)	IRWKLGEDDLSALLYLMDVSDDLVSAVKFLLW..LLPKVYSSPNSTIHSGRNVLMLP....RNMENQACDVSEafLLSSLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.29|      20|      20|      39|      58|       7
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   39-   56 (27.40/14.60)	..PLSSR.RQPLLTPYKLKCD
   57-   77 (36.75/22.65)	KEPLNSRlGPPDFHPQTPNCP
  866-  885 (34.13/20.39)	RKPIGSR.NKIDLLETTPGCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.46|      30|     218|     521|     552|       8
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  521-  552 (48.72/42.23)	KFLFEDLCDETVSEGwvAKVSHCLRLSLKWFR
  742-  771 (49.74/34.40)	KFVRDALVESGISEG..PQLTEALQIYLNERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.50|      12|      16|     191|     206|       9
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  191-  202 (20.04/17.41)	VPHVRRKSLLEV
  208-  219 (21.46/ 6.89)	VPLLRATWFIKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.63|      59|     813|     113|     176|      17
---------------------------------------------------------------------------
  113-  176 (91.48/67.40)	KGvvLNCKEAIR.....KRLRAINESRvQK..RKAGQVYGVALS...GSQLAKPG.VFPEQRPCPEdfKRKWIEG
  921-  990 (83.15/46.95)	KG..LKSSEPLKvdqplKPIKQVTKTR.QKtvRKTQSLAQLAASrieGSQGASTShMCDNKVSCPH..HRTAMNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      18|      19|     776|     794|      18
---------------------------------------------------------------------------
  776-  794 (29.59/21.10)	CsLWENHGNGSNVSISSLK
  798-  815 (31.07/17.47)	C.MSSTKDKASTVSIDQLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12070 with Med12 domain of Kingdom Viridiplantae
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