<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12070

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMQRYHAGSCTSAVNNTAVGGQSTRDIGRTDSSSLPANFPLSSRRQPLLTPYKLKCDKEPLNSRLGPPDFHPQTPNCPEETLTREYLQSGYRDTVEGLEESREISLTQVPNFNKGVVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLAKPGVFPEQRPCPEDFKRKWIEGLSQQHKRLRSLVDLVPHVRRKSLLEVLIRNNVPLLRATWFIKVTYLNVVRPGSASILSGIGDKTQQTCSELWTKDVVEYLQTLLDEFFSKNSSHFTHNRDRSPQLPYTASLQHRSDQLSVSDGEEPSLHFKWWYIVRLLQWHHTEGLLIPSLIIDWVLRQLQEKQSLEIWQLLLPIVYGFLEIVVLSQTYVRTLAGVALRVIRDPAPGGSDLVDNSRRAYTTSALIEMLRFLILAAPETFVALDCFPLPSSVVSYAINEGSFILKATEAAGKIKSSSEDVCLFKSKGFDAQYQSLAFDHVISCIQERVQDLTKAVKPGYPGQYLAKAAQALDKSLVLGDLHGAYKFLFEDLCDETVSEGWVAKVSHCLRLSLKWFRTVNTSFIYSVFFLCEWATCDFRDFRTAPCDVKFTGRKDLSQVHIAIRLLKMKLRDMQISTRQKSGNTRGHGFSYLGKCSGHQSNRNFVKNASRTKSSSRSMDQNICSSAIFESPGPLHDIIVCWIDQHMVHKGEGLKRVHLLVVELIQAGIFYPLAYVRQLIVSGIMDMNVVDLERQKRHCRILKQLPKKFVRDALVESGISEGPQLTEALQIYLNERRLILRCSLWENHGNGSNVSISSLKQKQCMSSTKDKASTVSIDQLKSAPSNKASSKSGKDGSGVEDLKTFISALLQLPKSLSNLGSTGLDESQSSVRKPIGSRNKIDLLETTPGCEECRKAKRQKLSEERSLFVQAPSPVLSDDEDTWWAKKGLKSSEPLKVDQPLKPIKQVTKTRQKTVRKTQSLAQLAASRIEGSQGASTSHMCDNKVSCPHHRTAMNGDTARSVDGIQLSECEDIVSIGKALKRLRFVERKEITLWLMSVIRELIEESEKVVGKVSQFGRPFATVDDKSSIRWKLGEDDLSALLYLMDVSDDLVSAVKFLLWLLPKVYSSPNSTIHSGRNVLMLPRNMENQACDVSEAFLLSSLRRYENILAAADLIPETLSSVMQRVAAIMASNGRVSGSGALAFARYLLKKYGNVVSVSEWEKNFKSTCDKRLAFEIESGRSVDGELGLPLGVPAGVEDPDDYFRQKISGGRLPSRVGSGMRDVVQRNVEEAFQYLFGKDRKLFAAGAPKGPAFEKWDNGYQNAQQIVAGLIDCIRQTGGAAQEGDSSLVTSAVSAIVGSVGPTLAKLPDFSAGSNQSNMSLATSSLNYAKCILRMHITCLCLLKEALGERQSRVFEIALAMEASTALAGVFAPSKASRAQFQMSPETHDAGTIPSDVSNNSSKIVVARTTKISAAVSALVVGAIIAGVVSLERIVTILRLKDGLDVVQFVRSTRSNSNGSVRSVGAFKVDCSVEVHVHWFRLLVGNCRTICEGLVVDLLDEPSIVALSRMQRMLSLSLVFPPAYSIFSFVMWRPFVMNANIAFREDMNQLYQSLTMAISDAIKHLPFRNVCLRDCQGLYDLMAANMTDAEFATLLELNGSDIHSKSLAFIPLRARHFLNALIECKMPQSIYTKEEGSRNSGHGESKIDFTDSESTLQDKLVDVLDALQPAKFHWQWVELRLLLNEQALIEKMKMHDISLADAIQLSSPSLEKSGASENENNFIEIILTRLLVRPDAAPLFSEVVHLFGKSLEDSMLLQAKWFLAGQDVLFGRKTIRQRLINIAESKRFSIKTQFSEPWGWCTPCKDPVTLKGDKKKVDSMPLEEGEVVEEGMDVKRSIKGFSPVFDSERSTSKQQHGTERALLELILPCIDQSSDESRNSFASDLIKQLNYIEQQIAVVTRGPTKPVNTPATEGQTNKVNSRKNIRSGSPGLARRPTPTPDSSSLSPAALRASISLRVQLLMRFLPIICTDGESSVRSMRYTLASVLLRLLGSRVVHEDAIVNAMQYSPLRKEAESPAEAAFVDSSVECLFDRMLLILHGLLSSSLPSWLRSKPVVKTSNESAREFSGFDREPLEALQNQLDNMQLPDTIRWRIQAAMPVLPFTIRCHFSCQLPTVPTSALASLQPNTTNSGFNSSSSTVPQRNPVPSSRTTASGKSKQQENDLDIDPWMLLEDGAGSCPSANNTNIIGSGDRVNIRAASWLKGAVRVRRTDLTYVGAVDEDS
Length2258
PositionKinase
OrganismVigna radiata var. radiata (Mung bean) (Phaseolus aureus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Vigna.
Aromaticity0.07
Grand average of hydropathy-0.228
Instability index51.24
Isoelectric point8.87
Molecular weight250687.27
Publications
PubMed=25384727

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12070
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      15|      18|     485|     499|       1
---------------------------------------------------------------------------
  485-  499 (28.63/18.24)	QDLTKAVKPG.YPGQY
  505-  520 (21.54/11.76)	QALDKSLVLGdLHGAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.41|      61|     375|    1654|    1722|       2
---------------------------------------------------------------------------
 1654- 1722 (86.78/62.47)	NALIEcKMPQSIYTKEEGSrnsghgESKIDFTDSE.STLQDKLVDVLDALQPAKFHwQWVELRLLL...NEQA
 2034- 2098 (90.62/45.14)	DAIVN.AMQYSPLRKEAES......PAEAAFVDSSvECLFDRMLLILHGLLSSSLP.SWLRSKPVVktsNESA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     271.17|      88|     606|    1299|    1395|       3
---------------------------------------------------------------------------
 1299- 1395 (132.97/113.82)	QQIVAGLIDCIRQTGGAAQEGDSSLVTSAVSAIVGSvgPTLAKLPDFSAGSNQ.SNMSL.ATSSLnYAKCILR.MHITClcllkeALGERQSRVFEIALA
 1929- 2019 (138.19/93.70)	QQIAVVTRGPTKPVNTPATEGQTNKVNSRKNIRSGS..PGLARRPTPTPDSSSlSPAALrASISL.RVQLLMRfLPIIC......TDGESSVRSMRYTLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.10|      36|     606|    1199|    1234|       4
---------------------------------------------------------------------------
 1199- 1234 (63.66/49.02)	F.KSTCDKRLAFEIESGR.SVDGELGLPLGVPAGVEDP
 1805- 1842 (60.44/46.05)	FgRKTIRQRLINIAESKRfSIKTQFSEPWGWCTPCKDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.89|      21|     379|     441|     461|       5
---------------------------------------------------------------------------
  441-  461 (35.45/23.17)	KATEAAGKIKSSSEDVCLFKS
  821-  841 (35.44/23.17)	KASSKSGKDGSGVEDLKTFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.22|      74|     745|     315|     394|       6
---------------------------------------------------------------------------
  315-  394 (117.56/92.14)	LQWHHTEGLLIPSLIIDWVLRQLQEKQSLEIWqlLLPIVYGFLEIVVLSQTYVRTLAgvalRVIRDPAPGGSD..LVDNSRR
 1063- 1138 (121.66/80.23)	IRWKLGEDDLSALLYLMDVSDDLVSAVKFLLW..LLPKVYSSPNSTIHSGRNVLMLP....RNMENQACDVSEafLLSSLRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.29|      20|      20|      39|      58|       7
---------------------------------------------------------------------------
   39-   56 (27.40/14.60)	..PLSSR.RQPLLTPYKLKCD
   57-   77 (36.75/22.65)	KEPLNSRlGPPDFHPQTPNCP
  866-  885 (34.13/20.39)	RKPIGSR.NKIDLLETTPGCE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.46|      30|     218|     521|     552|       8
---------------------------------------------------------------------------
  521-  552 (48.72/42.23)	KFLFEDLCDETVSEGwvAKVSHCLRLSLKWFR
  742-  771 (49.74/34.40)	KFVRDALVESGISEG..PQLTEALQIYLNERR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.50|      12|      16|     191|     206|       9
---------------------------------------------------------------------------
  191-  202 (20.04/17.41)	VPHVRRKSLLEV
  208-  219 (21.46/ 6.89)	VPLLRATWFIKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.63|      59|     813|     113|     176|      17
---------------------------------------------------------------------------
  113-  176 (91.48/67.40)	KGvvLNCKEAIR.....KRLRAINESRvQK..RKAGQVYGVALS...GSQLAKPG.VFPEQRPCPEdfKRKWIEG
  921-  990 (83.15/46.95)	KG..LKSSEPLKvdqplKPIKQVTKTR.QKtvRKTQSLAQLAASrieGSQGASTShMCDNKVSCPH..HRTAMNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.66|      18|      19|     776|     794|      18
---------------------------------------------------------------------------
  776-  794 (29.59/21.10)	CsLWENHGNGSNVSISSLK
  798-  815 (31.07/17.47)	C.MSSTKDKASTVSIDQLK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12070 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALASLQPNTTNSGFNSSSSTVPQRNPVPSSRTTASGKSKQQENDLDID
2) SCTSAVNNTAVGGQSTRDIGRTDSSSLPANFPLS
3) TRGPTKPVNTPATEGQTNKVNSRKNIRSGSPGLARRPTPTPDSSSLS
2155
8
1935
2202
41
1981










Molecular Recognition Features






MoRF SequenceStartStop




NANANA