<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12059

Description mediator of RNA polymerase II transcription subunit 26-like isoform X2
SequenceMTAATATPQQMRDRLMQAIDGQNNICNMVAVMDVISYLEKYPITKEALEETRLGKLINDVRKKTKDEDLVKRAKKLLRTWQKLIEPGQSEAQSKGHRGPPGAANGGNNPCRTDVSPPAAIPPSDKMVSELKSRNDFNNCYSPKAEKSGNRKRKGEQRDGQHLPAKISKKTANERTRNSQLPINGIGASPKAFMDTFDAHSHPKSDKDGADHLDNDRLNKIPINAVKPHPSSPGLAKPPSTSALLKTAVLQQQAKMDLVASGRGPHQPKSPHSNSYSPRRTKQDAVVKLSAPKATTLLSPAQSPRVMDSSGLGPSPLPSPQPLTSCIQGSLTVGPPSAESALHQDGPADVDQRLQHSTMRPDSLHNSKATSRSKVKAEGNGAATSTARKRRNKYRSRDYTVNLCGQPTEESTKPCRLKDRRLTFDPVTGQIKSWTHKESYPEWEAVVPVMPEPPRTELLKQNQYVQNPPVTPSPFQQTNWKELSRNEIIQSYLNRQSNVLTSSGAQTSGAHFFMNEYMEHHIKESRKTHVLVPNIPDMDLPEVSREVINEDLDRIHKEHWPGVNGCHDTKDNWYDWTECISLEPHGDESKLNILPYVCLD
Length599
PositionUnknown
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.04
Grand average of hydropathy-0.897
Instability index55.31
Isoelectric point9.26
Molecular weight66543.21
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP12059
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.15|      15|      48|     255|     271|       1
---------------------------------------------------------------------------
  255-  271 (27.36/18.49)	MDlvASGRGPHQPKSPH
  306-  320 (30.79/15.24)	MD..SSGLGPSPLPSPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.11|      38|      41|      89|     129|       2
---------------------------------------------------------------------------
   92-  129 (69.62/38.45)	QSKGHRG...PPGAANGGNNPCRTDVSPPAAIPP..SDKMVSE
  131-  173 (54.49/23.05)	KSRNDFNncySPKAEKSGNRKRKGEQRDGQHLPAkiSKKTANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.91|      25|     215|      62|      89|       4
---------------------------------------------------------------------------
   62-   89 (35.38/32.65)	KKTKDEDLVKRAKKLLRTwqkLIEPGQS
  278-  302 (40.53/26.66)	RRTKQDAVVKLSAPKATT...LLSPAQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12059 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EWEAVVPVMPEPPRTELLKQNQYVQNPPVTPSPFQQTNW
2) WQKLIEPGQSEAQSKGHRGPPGAANGGNNPCRTDVSPPAAIPPSDKMVSELKSRNDFNNCYSPKAEKSGNRKRKGEQRDGQHLPAKISKKTANERTRNSQLPINGIGASPKAFMDTFDAHSHPKSDKDGADHLDNDRLNKIPINAVKPHPSSPGLAKPPSTSALLKTAVLQQQAKMDLVASGRGPHQPKSPHSNSYSPRRTKQDAVVKLSAPKATTLLSPAQSPRVMDSSGLGPSPLPSPQPLTSCIQGSLTVGPPSAESALHQDGPADVDQRLQHSTMRPDSLHNSKATSRSKVKAEGNGAATSTARKRRNKYRSRDYTVNLCGQPTEESTKPCRLKDRRL
441
80
479
421










Molecular Recognition Features






MoRF SequenceStartStop




1) TWQKLI
79
84