<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP12058

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMMEVAYVCEWEKRPKSNHCPSIPLVCAWSCRNLVAFTTDLKNEEDEKVSHMVHIIDTEHPWDVYSIYSGHAEVISCLEWDQSGSRLLSADGDGQIKCWAMADHLVNSWETSLGSAVDGDPIIALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPNGQLLTASESLCRLRGRVSLADIAFTGGGNIVVAATDGSSSSPVQFYKVCVSVVNEKCRIDTELLPSLFMRCTTDPVRRDKYPAVTHLKFLTRENSEQVLLCASSQTGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPMILKWRILSATNDLDRVSAVALPKLPISISNPDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGSSSGSSQRPGEEPAIKRQRAGGHTVHFKALQFSWTSLALAGVDNHGKLHMIRVSPSMGQMLDMNTLLRHLLFLLEYCMVTGYDWWDVLLHVQPGMVHNLVEKLHEEYMRQNQALQQVLSTRIVAVKASLCKLSAATAARACDFHAKLLLIAISATLKSLLRPHVLNTPDKSPGDRLAEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLMANLPNQGSIVRPGFGFLRDGSSLGMLREMMVMIRIWGLLKPGCLPIYTATSDNQDSMSLLFRLLTKLWLCSRDEGHPQEPDEPLIDECCLLPSQLLVPSMDWLPVNDGIICKLQGKQPLRLQFGKPYSLPGLNSTAQVEIFSRSPGAQRMDNLRCLHMGVCPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRILSTLS
Length834
PositionTail
OrganismSalmo salar (Atlantic salmon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Protacanthopterygii> Salmoniformes> Salmonidae> Salmoninae> Salmo.
Aromaticity0.07
Grand average of hydropathy-0.039
Instability index45.42
Isoelectric point7.88
Molecular weight92570.42
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP12058
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.64|      24|      95|     440|     463|       1
---------------------------------------------------------------------------
  440-  463 (44.52/33.83)	DNHGKLHMIRVSPSMGQMLDMNTL
  539-  562 (39.12/28.73)	DFHAKLLLIAISATLKSLLRPHVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     330.38|     104|     418|     186|     329|       2
---------------------------------------------------------------------------
   77-  126 (59.57/16.39)	.........................................................................LEWDQS.....GSRLL..SADGD.GQI.KCWAM.ADHL.VNSWETSLGSAV.DGDPIIaLSW
  214-  329 (161.64/121.32)	GNIVVAA....TDGSSSSPVQFYKVCVSV...VNEKCridtelLPslFMRCTTDpvRRDK....YPAVTHLKFLTRENS.....EQVLL..CASSQTGSIVECWSLrKEGLPVNNIFQHRSPVVgEKQPMI.LKW
  629-  728 (109.17/49.52)	GSIVRPGfgflRDGSSLGMLREMMVMIRIwglLKPGC......LP..IYTATSD..NQDSmsllFRLLTKLWLCSRDEGhpqepDEPLIdeCCLLPSQLLVP..SM..DWLPVN.....................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP12058 with Med16 domain of Kingdom Metazoa
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